DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32052 and smpd1

DIOPT Version :9

Sequence 1:	NP_001303410.1	Gene:	CG32052 / 326184	FlyBaseID:	FBgn0044328	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001313465.1	Gene:	smpd1 / 556700	ZFINID:	ZDB-GENE-110411-222	Length:	591	Species:	Danio rerio

Alignment Length:	499	Identity:	141/499 - (28%)
Similarity:	213/499 - (42%)	Gaps:	111/499 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PGA-QARIGYFWHISDLHLDTLYSTQGDIYRSCWELARSVSGSNANSAAS---EPPGPFGHYN-C 78
            ||: ::||.:   ::|:|.|..| |:|    |..|..:.:...|.:..||   ...|.:|.|: |
Zfish   161 PGSPRSRILF---LTDIHWDAEY-TEG----SLAECNKPLCCRNDSGRASWRHAGAGYWGTYSKC 217

  Fly    79 DSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSHSAQPLSEQKQHEILRNITEL----LGRSFSS 139
            |.|.|.:|:.::.: ||.|. .::|.||||..:|:....:..:|...|..|:.|    |||:.:
Zfish   218 DLPLRTVENLLENV-AKSGP-WDWVYWTGDIPAHNVWSQTRNQQLNELVTISRLIHKHLGRNVT- 279

  Fly   140 QFIFPVLG-HED------------GSGS----YRRLGELWRHWLPSEALVTFDQGGYYSIEQTKS 187
              ::|.:| ||.            |:.|    |..:.:.|..|||.|||.|..:||:||:| .:.
Zfish   280 --VYPAVGNHESTPVNSFPPPFVHGNHSSRWLYETMAKEWAPWLPEEALETIRRGGFYSVE-VEP 341

  Fly   188 RLRIVALNTNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQWLWLEEVLTKS 252
            .||:|:||.||          .|....|         ..|:|....|:|      .||.::|.:|
Zfish   342 GLRLVSLNMNF----------CSRENYW---------LMVNSTDPADQL------QWLIQILQES 381

  Fly   253 KEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERN-NQRYLDMVRRFAPVIQGQFFGHLHSDTFR 316
            :.|.|.|:|:||:|||              |...: :..|..:|.|:...|.||||||.|:|.|:
Zfish   382 ENKGEKVHIIGHIPPG--------------FCLSSWSWNYYHIVNRYESTITGQFFGHTHTDEFQ 432

  Fly   317 LIYDAK--GNPISWLMIAPSIVPRKAGIGSSNNPALRLYKFD----TGSGQVLDYTQFWLDLPLA 375
            :.||.:  ..|:|...||||:.     ...:.||..|:|..|    ..|..|||:..|.|:|.||
Zfish   433 MFYDEETLTRPLSVAFIAPSVT-----TFVNLNPGYRVYYVDGNYPDSSRMVLDHETFILNLTLA 492

  Fly   376 NRA-----NEPTWQPEYNLTHYYALPEISAVALHNFAERFTGTD----LSWFTRYHRANAVRYHS 431
            |..     ..|:|...|..:..|.|..:....:....:.....|    ..|:. :|:.     |.
Zfish   493 NNRPLKPDPRPSWTLLYRASEAYGLSTLFPSDMEALIKHMVNDDRIFQQFWYL-FHKG-----HV 551

  Fly   432 GSACPGLCMLNHYCAITRLDYDEFRICLEKEQLALQGRAPAALM 475
            ...|...|..:..|.:....||....|     ..|.|..|...|
Zfish   552 SKPCKDTCKTSIICFLHSGRYDLLTQC-----SPLHGDTPKKSM 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32052	NP_001303410.1	MPP_ASMase	28..351	CDD:277321	105/350 (30%)
smpd1	NP_001313465.1	SapB	54..127	CDD:214797
		MPP_ASMase	168..464	CDD:277321	106/353 (30%)
		Metallophos	221..429	CDD:278574	76/252 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3770
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53732
OrthoDB	1	1.010	-	-		D369165at33208
OrthoFinder	1	1.000	-	-		FOG0000551
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R975
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.860