Protein Alignment ZnT33D and Slc30a5

DIOPT Version :10

• Sequence 1: NP_723732.2
• Gene: ZnT33D / 326167
• FlyBaseID: FBgn0051860
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_075023.2
• Gene: Slc30a5 / 69048
• MGIID: 1916298
• Length: 761
• Species: Mus musculus
• Alignment Length: 490
• Identity: 103/490 - (21%)
• Similarity: 204/490 - (41%)
• Gaps: 113/490 - (23%)

  Fly   191 WKRPTPVVLKSNQNYSANKNSENALDAKPQTATNTEETHGCINILKVPF--QSNLYYVPEKPSRQ 253
            |..|....|::....:..:::|:.|.             |.:.:..|.|  .:|:...|.|  |.
Mouse   318 WTHPITDQLRAMNRAAHQESTEHVLS-------------GGVVVSAVFFILSANILSSPSK--RG 367

  Fly   254 DKGS--GTSDFQPGAPE-TPIVENSAVDSDRKAVEIMPENVKNSEEKKIDNSDSTKTVTITGHSH 315
            .||:  |.|      || ||:..... |:.:.:.:.:|..:|:|.::.::.|||
Mouse   368 QKGTLIGYS------PEGTPLYHFMG-DAFQHSSQSVPRFIKDSLKQVLEESDS----------- 414

  Fly   316 ITAKWDGHCHFKERETGVDKAARRVLIIACILCTIFLILEVIGGILSNSLAIATDAAHLLTDLAS 380
                                  |::....| |..:|..:|:..|:|:|||.:.:|..|:|.|.::
Mouse   415 ----------------------RQIFYFLC-LNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSA 456

  Fly   381 FLISISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFELDAKIM 445
            .::.:.|..::...::...:||:.|.|::...::..|:.|:...:...::.|.::.. |||..::
Mouse   457 LVMGLFAALMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDPP-ELDTNML 520

  Fly   446 LITSALAILFNVIMAMQLQHGHSHSLPGVHKMSK-----DAGSVLGSKMILLLGKSVSMQYAAKG 505
            ...|...::.|:|......|.|||.    |..|:     |.|.                .:.|.|
Mouse   521 TPVSVGGLIVNLIGICAFSHAHSHG----HGASQGNCHSDHGH----------------SHHAHG 565

  Fly   506 H--------------ENINVRAAIIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLV 556
            |              .|.|:|...:||:.|.:.|.||.|:.::|..: .|...|.:|:...:||:
Mouse   566 HGHDHGHSHGFTGGGMNANMRGVFLHVLADTLGSIGVIVSTVLIEQF-GWFIADPLCSLFIAVLI 629

  Fly   557 LVVTFKILRDVLMVLMEATPDFMDYEEVKQTFLSISGVEHVHNL------RIWALSINKVALSAH 615
            .:....:::|...||:...|.  |:|  |:..:::..::.:..|      ..|..|.:.||.:.|
Mouse   630 FLSVIPLIKDACQVLLLRLPP--DHE--KELHIALEKIQKIEGLISYRDPHFWRHSASIVAGTIH 690

  Fly   616 LAISKDADPQLILEEATTLIHKRFKFFETTIQIEE 650
            :.::.:...|.|:::.|.:: |.......|||:|:
Mouse   691 IQVTSEVLEQRIVQQVTGIL-KDAGVNNLTIQVEK 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CzcD	312..649	CDD:440843	75/361 (21%)
Slc30a5	NP_075023.2	CzcD	411..726	CDD:440843	79/375 (21%)
		Mediates homodimerization with SLC30A6. /evidence=ECO:0000250|UniProtKB:Q8TAD4	418..636		54/240 (23%)
		His-rich loop, required for zinc transport. /evidence=ECO:0000250|UniProtKB:Q8TAD4	540..574		11/53 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..576		6/42 (14%)