Protein Alignment ZnT33D and SLC30A10

DIOPT Version :10

• Sequence 1: NP_723732.2
• Gene: ZnT33D / 326167
• FlyBaseID: FBgn0051860
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_061183.2
• Gene: SLC30A10 / 55532
• HGNCID: 25355
• Length: 485
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 90/377 - (23%)
• Similarity: 162/377 - (42%)
• Gaps: 72/377 - (19%)

  Fly   341 LIIACILCTIFLILEVIGGILSNSLAIATDAAHLLTDLASFLISISALHLAGRPS-SERLNYGWH 404
            |:...:|...|.:.|::.|.|.||:|:.:|:.::|:||.|..:.:||.::|.||: .....||:.
Human    11 LLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIARRPTRGFSATYGYA 75

  Fly   405 RAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQDFELDAKIMLITSALAILFNVIMAMQLQ----- 464
            ||||:||:.:..|:..:...:...|::|....:...|.:::||...|.:|.||:..:..|
Human    76 RAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAW 140

  Fly   465 -----HGHSHSL-----------PGVH---------KMSKDAGSVLGSKMILLLGKSV------- 497
                 .|.|..|           ||..         :.:.|..:......:.|.|.||
Human   141 FACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKG 205

  Fly   498 -------------------SMQYAAKGHENINVRAAIIHVVGDIIQSFGVFVAALIIFFWP---- 539
                               .|....|..|.:|:|..::||:||.:.|..|.:.|:|.:..|
Human   206 ATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSE 270

  Fly   540 ---EW-AFMDSVCTFVFSVLVLVVTFKILRDVLMVLMEATPDFMDYEEVKQTFLSISGVEHVHNL 600
               .| .::|...|.:..:::|...|.::::...:|::..|..::.||:.....::.|:..||.:
Human   271 DPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEV 335

  Fly   601 RIWALSINKVALSAHLAISKDADPQLILEEATTLIHKRFK---FFETTIQIE 649
            .||.|...|:..:.|:...||...|    :|:|.|.:.|.   ....|||.|
Human   336 HIWELVSGKIIATLHIKYPKDRGYQ----DASTKIREIFHHAGIHNVTIQFE 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CzcD	312..649	CDD:440843	89/375 (24%)
SLC30A10	NP_061183.2	CzcD	10..383	CDD:440843	89/375 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..196		2/28 (7%)
		Required for plasma membrane localization. /evidence=ECO:0000269|PubMed:25319704	308..485		22/80 (28%)