Protein Alignment ZnT33D and Slc30a4

DIOPT Version :10

• Sequence 1: NP_723732.2
• Gene: ZnT33D / 326167
• FlyBaseID: FBgn0051860
• Length: 701
• Species: Drosophila melanogaster
• Sequence 2: NP_035904.2
• Gene: Slc30a4 / 22785
• MGIID: 1345282
• Length: 430
• Species: Mus musculus
• Alignment Length: 495
• Identity: 148/495 - (29%)
• Similarity: 249/495 - (50%)
• Gaps: 86/495 - (17%)

  Fly   188 PKTWKR--------PTPVVLKSNQNYSANKNSENALDAKPQTATNTEETHGCINILKVPFQSNLY 244
            |..|||        .||:.|          |..:|.|...:.   ::|.....|.|:|....:..
Mouse     4 PGAWKRLKSLLRKDDTPLFL----------NDTSAFDFSDEV---SDEGLSRFNKLRVVVADDDS 55

  Fly   245 YVPEKPSRQDKGSGTSDFQPGA-PETPIVENSAVDSDRKAVEIMPENVKNSE-EKKIDNSDSTKT 307
            ..||:|..            || |.....::|.:|.|      :|  :.||: ..|:|..|:..
Mouse    56 EAPERPVN------------GAHPALQADDDSLLDQD------LP--LTNSQLSLKMDPCDNCS- 99

  Fly   308 VTITGHSHITAKWDGHCHFKERETGVDKAARRVLIIACILCTIFLILEVIGGILSNSLAIATDAA 372
                               |.||....:..:..|.||.:|..:|:|.|::||.::|||||.|||.
Mouse   100 -------------------KRRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDAL 145

  Fly   373 HLLTDLASFLISISALHLAGRPSSERLNYGWHRAEVIGAMVSIFFIWVVTGILVYMAIMRWVNQD 437
            |:||||::.::::.||.|:.:..:.|..:|:||.||:.||:|:..::|:.|.|:|.|:.|.::.:
Mouse   146 HMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAVQRTIHMN 210

  Fly   438 FELDAKIMLITSALAILFNVIMAMQL-QHGHSHSLPGVHKMSKDAGSVLGSKMILLLGKSVSMQY 501
            :|::..:||||:|:.:..||||...| |.||.||....|.:..::.|::.|      |.:
Mouse   211 YEINGDVMLITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSS------GHN----- 264

  Fly   502 AAKGHENINVRAAIIHVVGDIIQSFGVFVAALIIFFWPEWAFMDSVCTFVFSVLVLVVTFKILRD 566
              .|.:::.||||.:|.:||::||.||.:||.||.|.||:...|.:||::||:||...||:|:.|
Mouse   265 --HGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTFRIIWD 327

  Fly   567 VLMVLMEATPDFMDYEEVKQTFLSISGVEHVHNLRIWALSINKVALSAHLAI-----SKDADPQL 626
            .:::::|..|..::.:.:|::.:.|..|..|.:|.||:|:..|.....|:.:     ||..:.|
Mouse   328 TVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSKWEEVQ- 391

  Fly   627 ILEEATTLIHKRFKFFETTIQIEEY-SPGMENCGQCLSPS 665
              .:|..|:...|..::.|||::.| ...:..|..|.|.|
Mouse   392 --SKAKHLLLNTFGMYKCTIQLQSYRQEVIRTCANCHSSS 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT33D	NP_723732.2	CzcD	312..649	CDD:440843	114/342 (33%)
Slc30a4	NP_035904.2	CDF	123..414	CDD:273544	107/306 (35%)
		Zinc binding. /evidence=ECO:0000250|UniProtKB:O55174	240..265		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..264		4/24 (17%)