Protein Alignment exd and PBX3

DIOPT Version :10

• Sequence 1: NP_523360.1
• Gene: exd / 32567
• FlyBaseID: FBgn0000611
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_001397938.1
• Gene: PBX3 / 5090
• HGNCID: 8634
• Length: 455
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 276/433 - (63%)
• Similarity: 298/433 - (68%)
• Gaps: 83/433 - (19%)

  Fly     1 MEDPNRML---------AHT--GGM-MAPQGYGLSGQD-DGQNAGSENEVRKQKDIGEILQQIMS 52
            |:|.:|||         .|:  ||| :.|..:|..|.| ||         ||| |||:||.|||:
Human     1 MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDG---------RKQ-DIGDILHQIMT 55

  Fly    53 ISEQSLDEAQARKHTLNCHRMKPALFSVLCEIKEKTVLSIRNTQEEEPPDPQLMRLDNMLIAEGV 117
            |::||||||||:||.|||||||||||||||||||||.||||..|||:|||||||||||||:||||
Human    56 ITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGV 120

  Fly   118 AGPEKGGGGAAAASAAAASQGGSLSIDGADNAIEHSDYRAKLAQIRQIYHQELEKYEQACNEFTT 182
            :|||||||.||||:|||||.|.|      ||:||||||||||.|||||||.||||||||||||||
Human   121 SGPEKGGGSAAAAAAAAASGGSS------DNSIEHSDYRAKLTQIRQIYHTELEKYEQACNEFTT 179

  Fly   183 HVMNLLREQSRTRPITPKEIERMVQIIHKKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSK 247
            |||||||||||||||:||||||||.|||:||||||||||||||||||||||||||||||||||||
Human   180 HVMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSK 244

  Fly   248 QASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQ---------------------VSNWFGN 291
            ||:|||||||||||||||||||||||||:||.|||||                     |||||||
Human   245 QATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQSLVKDPKERGSKGSDIQPTSVVSNWFGN 309

  Fly   292 KRIRYKKNIGKAQEEANLYAAKKAAGASPYSMAGPPSGTTTPMMSPAPPQD----SMGYPMGSG- 351
            |||||||||||.||||||||||.|..|:....|...:..|.   ||..|..    |...| .||
Human   310 KRIRYKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTN---SPTTPNSGSSGSFNLP-NSGD 370

  Fly   352 ------------------GYDQQQPYD------NSMGGYDPNL 370
                              |.:.|...|      |..|||...|
Human   371 MFMNMQSLNGDSYQGSQVGANVQSQVDTLRHVINQTGGYSDGL 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_523360.1	PBC	42..237	CDD:461052	165/194 (85%)
		homeodomain	239..299	CDD:238039	56/80 (70%)
PBX3	NP_001397938.1	PBC	45..234	CDD:461052	165/194 (85%)
		homeodomain	236..317	CDD:238039	56/80 (70%)