Protein Alignment exd and PBX2

DIOPT Version :10

• Sequence 1: NP_523360.1
• Gene: exd / 32567
• FlyBaseID: FBgn0000611
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_002577.2
• Gene: PBX2 / 5089
• HGNCID: 8633
• Length: 430
• Species: Homo sapiens
• Alignment Length: 384
• Identity: 265/384 - (69%)
• Similarity: 293/384 - (76%)
• Gaps: 40/384 - (10%)

  Fly    12 GGMMAPQGYGLSGQDDGQNAGSENEVRKQKDIGEILQQIMSISEQSLDEAQARKHTLNCHRMKPA 76
            ||...|.|    |.|.|..:|.....|.::|||:||||||:|::||||||||:||.|||||||||
Human    26 GGPGEPPG----GGDPGGGSGGVPGGRGKQDIGDILQQIMTITDQSLDEAQAKKHALNCHRMKPA 86

  Fly    77 LFSVLCEIKEKTVLSIRNTQEEEPPDPQLMRLDNMLIAEGVAGPEKGGGGAAAASAAAASQGGSL 141
            ||||||||||||.||||::|||||.|||||||||||:||||||||||||.||||:|||||.||.
Human    87 LFSVLCEIKEKTGLSIRSSQEEEPVDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGGV- 150

  Fly   142 SIDGADNAIEHSDYRAKLAQIRQIYHQELEKYEQACNEFTTHVMNLLREQSRTRPITPKEIERMV 206
               ..||:|||||||:||||||.|||.||||||||||||||||||||||||||||:.|||:||||
Human   151 ---SPDNSIEHSDYRSKLAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMERMV 212

  Fly   207 QIIHKKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQASEILNEYFYSHLSNPYPSEEAK 271
            .|||:|||:||||||||||||||||||||||||||||||||||:|:|||||||||||||||||||
Human   213 SIIHRKFSAIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAK 277

  Fly   272 EELARKCGITVSQVSNWFGNKRIRYKKNIGKAQEEANLYAAKKA-----AGASPYSMAGPPSGTT 331
            ||||:||||||||||||||||||||||||||.|||||:||.|.|     .|.|..|...|||...
Human   278 EELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVTQGGHSRTSSPTPPSSAG 342

  Fly   332 T----------------PMMS----PAPPQDSMGYPMGSGGYDQQQPYDNSMGG--YDP 368
            :                |.::    .|...:|:.:.||.|||.     ||..||  |.|
Human   343 SGGSFNLSGSGDMFLGMPGLNGDSYSASQVESLRHSMGPGGYG-----DNLGGGQMYSP 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_523360.1	PBC	42..237	CDD:461052	163/194 (84%)
		homeodomain	239..299	CDD:238039	56/59 (95%)
PBX2	NP_002577.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		9/29 (31%)
		PBC	52..243	CDD:461052	163/194 (84%)
		PBC-A. /evidence=ECO:0000255|PROSITE-ProRule:PRU01322	55..134		67/78 (86%)
		PBC-B. /evidence=ECO:0000255|PROSITE-ProRule:PRU01322	137..243		90/109 (83%)
		homeodomain	245..305	CDD:238039	56/59 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	326..347		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..430		11/24 (46%)