Protein Alignment Lcch3 and GABRQ

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_061028.3
• Gene: GABRQ / 55879
• HGNCID: 14454
• Length: 632
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 176/594 - (29%)
• Similarity: 284/594 - (47%)
• Gaps: 160/594 - (26%)

  Fly    40 VTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNI 104
            |.:.:..:|..||:||||||||.|:.|.:.:.:.|.:.|||:||||||||:.:|.|:|.|||
Human    59 VQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA--- 120

  Fly   105 FGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMR 169
               |::...:      |||.....||:||||.:|.|.|::|:||||..|::.:|..||.|.||:|
Human   121 ---YYETTLN------LTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIR 176

  Fly   170 FTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYW--KPTPVRGVEDAELPQFTIIGYETN 232
            .|||.||.:|||.:|:|.|.|.:.:|||||||.|::::|  ....:...|:..:||||.:|....
Human   177 LTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTIT 241

  Fly   233 DRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVL 297
            .::....||.|.||.|.|::||.:..::.|.|.|::|..:.||:|||:|:::::|||.:|:|::|
Human   242 SKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSML 306

  Fly   298 TMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKKIKKVKE---- 358
            .:|||.:.:|..||.||.:||||||:::|..|||.:||||..:||.::.:..:::.::.:.
Human   307 ILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPRRHRRPRRV 371

  Fly   359 -------------------------------------CCPGKIGK----SERSETCSTTEDIIEL 382
                                                 ..|..:|.    ||::: .:|:|.:..|
Human   372 IARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTSTSEQAQ-LATSESLSPL 435

  Fly   383 QDV----------RMSPIPS----------LRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGT 427
            ..:          .:|.:||          :|...:.|....|.||..|..: .....:|.::..
Human   436 TSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPTEIRNRVE-AHGHGVTHDHED 499

  Fly   428 GHSQLR--RRAQRGISTRPRMLHALKRGAS----------------AIKAT-------------- 460
            .:..|.  .|...|.|.:| |||..::|..                |||..
Human   500 SNESLSSDERHGHGPSGKP-MLHHGEKGVQEAGWDLDDNNDKSDCLAIKEQFKCDTNSTWGLNDD 563

  Fly   461 ----------------------------------------IPKIKDVNIIDKYSRMIFPISFLAF 485
                                                    :||      :||:||.:||::|..|
Human   564 ELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPK------VDKWSRFLFPLAFGLF 622

  Fly   486 NLGYWLFYI 494
            |:.||::::
Human   623 NIVYWVYHM 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	176/591 (30%)
GABRQ	NP_061028.3	LGIC_ECD_GABAAR_theta	82..264	CDD:349804	81/193 (42%)
		Cys-loop	183..197	CDD:349804	7/13 (54%)
		LGIC_TM_GABAAR_theta	267..>355	CDD:349858	40/87 (46%)
		TM1 helix	267..290	CDD:349858	9/22 (41%)
		TM2 helix	294..318	CDD:349858	10/23 (43%)
		TM3 helix	326..352	CDD:349858	15/25 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..458		10/48 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..523		9/32 (28%)
		LGIC_TM	<598..630	CDD:476813	13/37 (35%)
		TM4 helix	606..627	CDD:349850	10/26 (38%)