Protein Alignment Lcch3 and Gabrd

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_058985.1
• Gene: Gabrd / 29689
• RGDID: 61901
• Length: 449
• Species: Rattus norvegicus
• Alignment Length: 474
• Identity: 180/474 - (37%)
• Similarity: 265/474 - (55%)
• Gaps: 63/474 - (13%)

  Fly    31 DVLAGRLE-NVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQY 94
            |.:...|| :....:..:::||....||..||.|::|.:.|.:||.|.|||.||:||:|::|:|.
  Rat    30 DYVGSNLEISWLPNLDGLMEGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQS 94

  Fly    95 WRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLG 159
            |||.||::|            ..::.|.|...|.:|:|:||||..|.|:::.||||..|||:||.
  Rat    95 WRDSRLSYN------------HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQ 147

  Fly   160 GDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPT--PVRGVEDAELP 222
            .||.:.|.:|.|:|:||.|||..||:|.|.|.:::|||||:..|:|.||...  .:.|::..:|.
  Rat   148 PDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLA 212

  Fly   223 QFTIIGYE-TNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATS 286
            ||||..|. |.:.....:.|.:.||||.|:|:||.|.::.|:|:||:|:|.:|||||||:..|..
  Rat   213 QFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVP 277

  Fly   287 ARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTY-WGKRAK 350
            |||:|||||||||||:....||||||.|.:||:|:|..:|:|||||||:|||..::.. :.|:.|
  Rat   278 ARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRK 342

  Fly   351 KKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNA----TLDSIGTETMN 411
            .|:|..|          .|:|           .|||            ||    :|.:.|. :..
  Rat   343 AKVKVTK----------PRAE-----------MDVR------------NAIVLFSLSAAGV-SQE 373

  Fly   412 LGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRM 476
            |.......|:..|....:..:...|::...:||       .|...|::.:..| |.:.||.|:|.
  Rat   374 LAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRP-------GGPGGIRSRLKPI-DADTIDIYARA 430

  Fly   477 IFPISFLAFNLGYWLFYIL 495
            :||.:|.|.|:.||..|.:
  Rat   431 VFPAAFAAVNIIYWAAYTM 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	179/470 (38%)
Gabrd	NP_058985.1	LGIC_ECD	63..246	CDD:475126	82/194 (42%)
		LGIC_TM	249..>337	CDD:476813	50/87 (57%)
		TM1 helix	252..272	CDD:349850	12/19 (63%)
		TM2 helix	281..302	CDD:349850	14/20 (70%)
		TM3 helix	312..334	CDD:349850	12/21 (57%)