Protein Alignment Lcch3 and Gabra2

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_017454595.1
• Gene: Gabra2 / 289606
• RGDID: 61856
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 501
• Identity: 166/501 - (33%)
• Similarity: 246/501 - (49%)
• Gaps: 82/501 - (16%)

  Fly    10 SCGLFFFLL------GAQLQLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGM 68
            :|.::|.||      .|:|.|.. |::|.....:...|:.:..:|.|||.||||..|.....|..
  Rat    60 TCNVWFPLLVLLVWNPARLVLAN-IQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFT 123

  Fly    69 DLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWV 133
            ::.:.||..:|:.:|:|||.::..|.|:||||.|.            |..::|.|:...|.|||.
  Rat   124 NIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFK------------GPMNILRLNNLMASKIWT 176

  Fly   134 PDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYG 198
            |||||.|.|.|..|::|..|||:|:..||.:.|.||.|....|.|.|..:|:|:.:|.::..||.
  Rat   177 PDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYA 241

  Fly   199 YTVSDVVMYWKPTPVRGVEDA----ELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYF 259
            ||.|:|...|.......|:.|    .|.|:.::|........:.:||.|..::..|.|:|.||||
  Rat   242 YTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYF 306

  Fly   260 VFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLV 324
            |.|||||.|:.|:||.||||:|.|:..||...|:||||||||:|...|:|||:::|..|:|.::.
  Rat   307 VIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIA 371

  Fly   325 MCFVFVFAALLEYAAVNY------TYWGKRAKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQ 383
            :|:.|||:||:|:|.|||      .:.||......||.|                    ..:.:|
  Rat   372 VCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEK--------------------GSVMIQ 416

  Fly   384 DVRMSPIPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLH 448
            :              ||...::.....||.|.|....|:::                :|.|....
  Rat   417 N--------------NAYAVAVANYAPNLSKDPVLSTISKS----------------ATTPEPNK 451

  Fly   449 ALKRGASAIKATIPKIKDVNIIDKYSRMIFPISFLAFNLGYWLFYI 494
            ..:...:..|.|   ...|:.||:.||::||:.|..|||.||..|:
  Rat   452 KPENKPAEAKKT---FNSVSKIDRMSRIVFPVLFGTFNLVYWATYL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	164/493 (33%)
Gabra2	XP_017454595.1	LIC	64..493	CDD:455710	164/494 (33%)
		LGIC_ECD_GABAAR_A2	100..302	CDD:349836	74/213 (35%)
		Cys-loop	219..233	CDD:349836	5/13 (38%)