Protein Alignment Lcch3 and acc-3

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_508810.2
• Gene: acc-3 / 186307
• WormBaseID: WBGene00018880
• Length: 517
• Species: Caenorhabditis elegans
• Alignment Length: 480
• Identity: 124/480 - (25%)
• Similarity: 230/480 - (47%)
• Gaps: 65/480 - (13%)

  Fly    44 ISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAFNIFGQY 108
            |..:|..|.....|:..|  :.|.:::.:...::::|:..|:.:.:|:.:.|.|..|.:
 Worm    70 IEKLLNNYKSFRTPSESG--VIVWIEVWVQEVNSVNEITSDFDMDIYVTELWMDSALRY------ 126

  Fly   109 FDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYGMRFTTT 173
               |:.:.....|:|:.:..::||.|:|.|.|.|::.:|....:|..:.:..:|.|....|....
 Worm   127 ---EHLNPCKYNLSLNSEILDQIWKPNTVFINSKSANIHKSPFKNVFLMIYPNGTVWVNYRVQVK 188

  Fly   174 LACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWK--PTPVRGV-EDAELPQFTIIGYETNDRK 235
            ..|.||...:|:|.|:|.:.:||:.|...:|.|.|.  .||:..: ::..||.|.:..|.|:.:.
 Worm   189 GPCSMDFSAFPMDQQSCHLTLESFSYNNQEVDMQWMNWTTPLSLLKKEIVLPDFVMSNYSTSLKH 253

  Fly   236 ERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMT 300
            |....||:..|:::|...|..|:::||.|:|:.|.:.:||:||.:..:...||..||:.::|.:|
 Worm   254 EIYPAGVWNELTMTFVFSRRYGWYIFQAYIPTYLTIFISWISFCLGPKMIPARTMLGVNSLLALT 318

  Fly   301 TISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKRAKKK---IKKVKECCPG 362
            .....:..:|||:|||||:|:::::|..|||.:|||.|.:.  ..|.|::.:   .:|.::....
 Worm   319 FQFGNIMRNLPRVSYVKALDVWMLVCLTFVFCSLLELAIIG--SMGARSENRQAQQQKQQDEEAT 381

  Fly   363 KIGKSERSETCSTTEDIIELQDVRMSP--IPSLRRGTYNATLDSIGTETMNLGKFPPSFRITRNY 425
            |..|...:.|||..          |||  .|:..|...|...:.:          |.||   ::|
 Worm   382 KHQKGRENSTCSHL----------MSPSSCPNSPRICRNHIPNDV----------PQSF---KSY 423

  Fly   426 GTGHSQLRRR----AQRGISTRPR--------MLHALKRGA-SAIKATIPKIKDVNI-------- 469
            |:...::|:|    :...||..|.        :|..|:... |.::.....:..:.:
 Worm   424 GSTDPRMRKRLIIASSSTISHAPNANRSEKVLLLDGLEETQFSQVETKFSSMASIKMKKHWTTEE 488

  Fly   470 IDKYSRMIFPISFLAFNLGYWLFYI 494
            ||:.|.::||..|..||:.||.:|:
 Worm   489 IDRLSMIMFPGLFTLFNIIYWTYYL 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	123/477 (26%)
acc-3	NP_508810.2	LIC	69..512	CDD:455710	123/477 (26%)
		LGIC_ECD_GABAAR	88..273	CDD:349791	47/193 (24%)
		Cys-loop	191..205	CDD:349791	6/13 (46%)