Protein Alignment Lcch3 and lgc-49

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_505841.2
• Gene: lgc-49 / 179547
• WormBaseID: WBGene00010741
• Length: 457
• Species: Caenorhabditis elegans
• Alignment Length: 470
• Identity: 117/470 - (24%)
• Similarity: 193/470 - (41%)
• Gaps: 84/470 - (17%)

  Fly    27 CIRKDVLAGRLENVTQTISNILQGYDIRLRPNFGGEPLHVGMDLTIASFDAISEVNMDYTITMYL 91
            |.|:..:..:|.|.|        ||:....||..|.|:.|  :..:.:..:|:|:..|:.:.:|:
 Worm    51 CTRQPAIIDKLLNGT--------GYNKFRIPNENGVPVQV--EFWVQAITSINEITNDFEMDIYI 105

  Fly    92 NQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLV 156
            |:.|.|..|.|         ::.:.....|::|....|::|.|::.|.|.|.:.:||...:|..:
 Worm   106 NEMWLDPALKF---------DHLNPCKQNLSVSHQVLEQLWTPNSCFVNSKFAEIHDSPFKNVFL 161

  Fly   157 RLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYW---KPTPVRGVED 218
            .:..:|.|....|......|.:.|..:|||.|.|.:..||:.|...:|.|.|   ...||.....
 Worm   162 MIYPNGTVWVNYRVNVKGPCDLSLELFPLDIQECHLIYESFNYNNQEVRMRWNEKSAEPVSVTNK 226

  Fly   219 AELPQFTIIGYETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHE 283
            ..||.|.:|..|:.........|::..|.:....:|...::..|.|||:.|.:.:||:||.:..:
 Worm   227 IRLPDFELIKIESTRISAPYPAGMWDELHVKLVFERRYIWYFMQAYLPTYLTIFISWISFSLGTK 291

  Fly   284 ATSARVALGITTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGKR 348
            |..||..||:..:|.|......:..:|||:|||||||:::::...|:|.:|||.|.|.|....:.
 Worm   292 AMPARTMLGVNALLAMIFQFGNIMRNLPRVSYVKAIDVWMLVSMTFIFLSLLELAIVGYKTKNEE 356

  Fly   349 AKKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDSIGTETMNLG 413
            ..||      .||.|                                    ..||:.......|.
 Worm   357 GSKK------KCPHK------------------------------------KLLDNFEASPAGLC 379

  Fly   414 KFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHALKRGASAIKATIPKIKDVNIIDKYSRMIF 478
            ::...|.:...        ||.|:.|...|.::.......:.            ..||:.|.::|
 Worm   380 RYEKRFMLPVE--------RRSARWGGIIRFQVFQDFWNWSP------------EKIDRVSAIMF 424

  Fly   479 PISFLAFNLGYWLFY 493
            |..|..||:.||.:|
 Worm   425 PACFAIFNIVYWSYY 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	116/468 (25%)
lgc-49	NP_505841.2	LIC	53..439	CDD:455710	115/466 (25%)
		LGIC_ECD_GABAAR	78..263	CDD:349791	47/195 (24%)
		Cys-loop	181..195	CDD:349791	6/13 (46%)