Protein Alignment Lcch3 and Gabra4

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001345970.1
• Gene: Gabra4 / 14397
• MGIID: 95616
• Length: 578
• Species: Mus musculus
• Alignment Length: 587
• Identity: 191/587 - (32%)
• Similarity: 276/587 - (47%)
• Gaps: 135/587 - (22%)

  Fly     8 GVSCGLFFFLLGAQLQLIRCIR-------KDVLAGRL--ENVTQTISNILQGYDIRLRPNFGGE- 62
            |||..|..||.     |..|:.       ||   .:|  ||.|:.:.::|.|||.||||.|||.
Mouse    15 GVSLALLHFLC-----LAACLNESPGQNSKD---EKLCPENFTRILDSLLDGYDNRLRPGFGGTD 71

  Fly    63 ------------------------PL-HVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLAF 102
                                    |: .|..|:.:.||..:|:|.|:||:.::..|.|.|:||.:
Mouse    72 CFKTCKCALSVRLWSACLFVEILGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKY 136

  Fly   103 NIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGAVTYG 167
                        ||..::|.|:.....|:|.|||||.|.|.|..|::|..|||.|:..:|.:.|.
Mouse   137 ------------DGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYT 189

  Fly   168 MRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPTPVRGV----EDAELPQFTIIG 228
            ||.|.:..|.|.|..:|:|...|.::..||.|..|:::..|...|.:.|    |.:.|.|:.:||
Mouse   190 MRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIG 254

  Fly   229 YETNDRKERLATGVYQRLSLSFKLQRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGI 293
            ...:....:..||.|..:::.|.|:|.:|||:.|||:|.|:.|:||.||||||.|:..||...||
Mouse   255 QTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGI 319

  Fly   294 TTVLTMTTISTGVRSSLPRISYVKAIDIYLVMCFVFVFAALLEYAAVNY--TYWGKRAKKKIKKV 356
            ||||||||:|...|.|||::||..|:|.::.:||.|||:||:|:|||||  ....::|||||.|.
Mouse   320 TTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKP 384

  Fly   357 KECCP-GKIGKSERSETCSTTEDIIELQDVRMSPIPSLRRGTYNATLDS---------IG----- 406
            ....| ..:.|.:.:||        .||:...:  .::|:.| ||.:.|         :|
Mouse   385 PPEVPAAPVLKEKHTET--------SLQNTHAN--LNMRKRT-NALVHSESDVKSRTEVGNHSSK 438

  Fly   407 ----------TETMNLGKFPPSF----------RITRNYGTG-----HSQLRRRAQRGISTRPRM 446
                      |...:|...|..|          ...|...:.     |..||..:....||||..
Mouse   439 TSAVQESSEATPKAHLASSPNPFSRANAAETMSAAARGLSSAASPSPHGTLRPASLGSASTRPAF 503

  Fly   447 LHALKRGASAIKATI-------------------PKIKDVNIIDKYSRMIFPISFLAFNLGYWLF 492
            ...|.|    ||.|:                   |.....:.||||:|::||::|.|||:.||:.
Mouse   504 GSRLGR----IKTTVNTTGAAGNVSATPPPPAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV 564

  Fly   493 YI 494
            |:
Mouse   565 YL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	186/577 (32%)
Gabra4	NP_001345970.1	LIC	13..565	CDD:455710	190/584 (33%)
		LGIC_ECD_GABAAR_A4	57..281	CDD:349838	73/235 (31%)
		Cys-loop	198..212	CDD:349838	5/13 (38%)