Protein Alignment Lcch3 and CHRNG

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_005190.4
• Gene: CHRNG / 1146
• HGNCID: 1967
• Length: 517
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 98/486 - (20%)
• Similarity: 187/486 - (38%)
• Gaps: 103/486 - (21%)

  Fly    18 LGAQLQLIRCIRKDVLAGRLENVTQTISNILQGYDIRLRP-NFGGEPLHVGMDLTIASFDAISEV 81
            ||||             ||.:. .:.:::::|.||..||| ....:.::|.:.||:.:..:::|.
Human    18 LGAQ-------------GRNQE-ERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNER 68

  Fly    82 NMDYTITMYLNQYWRDERLAFNIFGQYFDDENDDGISDVLTLSGDFAEKIWVPDTFFANDKNSFL 146
            ....|..:::...|.|.||.       :|..:.:|:. ||.:.   :..:|.||....|:.:...
Human    69 EEALTTNVWIEMQWCDYRLR-------WDPRDYEGLW-VLRVP---STMVWRPDIVLENNVDGVF 122

  Fly   147 HDVTERNKLVRLGGDGAVTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKPT 211
            ......|.||  ..||.:.:........||.:.:.|:|.|.|||::..:|..|:.:::.:.....
Human   123 EVALYCNVLV--SPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQE 185

  Fly   212 PVRGVE----DAELPQFTIIG-YETNDRKERL--------ATGVYQRLSLSFKLQRNIGYFVFQT 263
            ..:.:|    |.|  .||..| :....|..::        ....:|::.....:||...::|...
Human   186 DGQTIEWIFIDPE--AFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINI 248

  Fly   264 YLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRISY-VKAIDIYLVMCF 327
            ..|.:||..::.:..::..:|...:..:.|..:|..|.....|...:|..|. |..|..||.  |
Human   249 IAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLT--F 311

  Fly   328 VFVFAALLEYAAV---------NYTYWGKRAKKKI----------KKVKECCPGKIGKSE-RSET 372
            :.|...|:...||         .:|:...|..:|:          ..|:...|..:..:: |.:.
Human   312 LLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQDTQSRLQN 376

  Fly   373 CSTTEDIIELQDVRMS-PIPSL------RRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHS 430
            .|:...|...::|.:. |...|      |:|...|.|:
Human   377 GSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALE--------------------------- 414

  Fly   431 QLRRRAQRGISTRPRMLHALKRGASAIKATI 461
            :|.:..:.|:|   :...:||:.|.||:|.:
Human   415 KLEKGPELGLS---QFCGSLKQAAPAIQACV 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	98/486 (20%)
CHRNG	NP_005190.4	LGIC_ECD_nAChR_G	49..241	CDD:349830	42/206 (20%)
		Cys-loop	150..164	CDD:349830	5/13 (38%)
		Neur_chan_memb	248..492	CDD:460753	43/227 (19%)