Protein Alignment Lcch3 and CHRNB3

DIOPT Version :10

• Sequence 1: NP_996469.1
• Gene: Lcch3 / 32554
• FlyBaseID: FBgn0010240
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 98/498 - (19%)
• Similarity: 195/498 - (39%)
• Gaps: 127/498 - (25%)

  Fly    38 ENVTQTISNILQGYDIRLRPNF-GGEPLHVGMDLTIASFDAISEVNMDYTITMYLNQYWRDERLA 101
            ||....:.::.|||...:||.. ..:.:.|...|.|:....:.|.|...|..::|.|.|.|.:|.
Human    27 ENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLR 91

  Fly   102 FNIFGQYFDDENDD--GISDVLTLSGDFAEKIWVPD-TFFANDKNSFLHDVTERNKLVRLGGDGA 163
            :|         .||  ||..:...|    |.:|:|| ..|.|....|...:..:   |.:..:|.
Human    92 WN---------PDDYGGIHSIKVPS----ESLWLPDIVLFENADGRFEGSLMTK---VIVKSNGT 140

  Fly   164 VTYGMRFTTTLACMMDLHYYPLDSQNCTVEIESYGY--TVSDVVMY--------------WKPTP 212
            |.:....:...:|.||:.::|.|.|||:::..|:.|  |:.|:::.              |:...
Human   141 VVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILN 205

  Fly   213 VRGVEDAELPQFTIIGYETNDRKERLATGVYQR--LSLSFKLQRNIGYFVFQTYLPSILIVMLSW 275
            .:|::              .:|::    |||..  ::.||.|:|...::.....:|.:.:..|:.
Human   206 AKGMK--------------GNRRD----GVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTV 252

  Fly   276 VSFWINHEATSARVALGITTVLTMTTISTGVRSSLPRIS-YVKAIDIYLVMCFVFVFAALLEYAA 339
            :.|::..: ...:::|..:.::::|.....:...:|..| .:..|..||:...:||..:::....
Human   253 LVFYLPSD-EGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVF 316

  Fly   340 V-------NYTY-----WGKRA-KKKIKKVKECCPGKIGKSERSETCSTTEDIIELQDVRMSPIP 391
            |       :.||     |.||. .:|:.|:. |....:.:....|. ..::.:::
Human   317 VINVHHRSSSTYHPMAPWVKRLFLQKLPKLL-CMKDHVDRYSSPEK-EESQPVVK---------- 369

  Fly   392 SLRRGTYNATLDSIGTETMNLGKFPPSFRITRNYGTGHSQLRRRAQRGISTRPRMLHA-LKRGAS 455
                                 ||.                |.::.|:.:|...::|.| |::.|.
Human   370 ---------------------GKV----------------LEKKKQKQLSDGEKVLVAFLEKAAD 397

  Fly   456 AIKATIPKIKDVNIIDKYSRMIFPISFLAFNLG---YWLFYIL 495
            :|:.....:|..:.|   |:::....|:|..|.   .|||.|:
Human   398 SIRYISRHVKKEHFI---SQVVQDWKFVAQVLDRIFLWLFLIV 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lcch3	NP_996469.1	LIC	15..493	CDD:273305	96/494 (19%)
CHRNB3	NP_000740.1	LIC	23..449	CDD:455710	98/498 (20%)