Protein Alignment CycD and CCNF

DIOPT Version :10

• Sequence 1: NP_523355.2
• Gene: CycD / 32551
• FlyBaseID: FBgn0010315
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_001752.2
• Gene: CCNF / 899
• HGNCID: 1591
• Length: 786
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 66/332 - (19%)
• Similarity: 133/332 - (40%)
• Gaps: 83/332 - (25%)

  Fly   140 TAIGDPTLYSDRCLENFLKVEEKHHK--------------------------------------- 165
            |.:.||    .|||.:|.|:.:...|
Human   232 TDVSDP----GRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQA 292

  Fly   166 -IPDTYFSIQKDITPPMRKIVAEWMMEVCAEENCQEEVVLLALNYMDRFLSSKSVRKTQLQILAA 229
             .....||:||.:...||.|:.:|::||...::.....:.|.:..:||:|..:.|.:.:||:|..
Human   293 VSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGI 357

  Fly   230 ACLLLASKLREPSCRALSVDLLVV-----YTDNSIYKDDLIKWELYVLSRLGWDLSSVTPLDFLE 289
            ||:::.:       |.:|.::|.:     .|||:...:||::....::|.|...:...|.:|:.|
Human   358 ACMVICT-------RFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKE 415

  Fly   290 LLMMRLPIGSKNFPDINIGKVRGHAQAFI-SLAAKEHKFAKFSASTIAASSIAASMNGLKWHLRS 353
            :|:..:|:..:.          .|..:|: .|:......:.::.:.:||:::      |...|..
Human   416 VLLTLVPVELRT----------QHLCSFLCELSLLHTSLSAYAPARLAAAAL------LLARLTH 464

  Fly   354 GHNLHFLLSLMTDLTSVEQAQVRDCMLHM-EDIFKEHSRNLEPFLVNIDPKEMSTLYYKRRFQIH 417
            |....:...|. |||......:..|:|.: :..|.:.:..        |.:::|....|:||:..
Human   465 GQTQPWTTQLW-DLTGFSYEDLIPCVLSLHKKCFHDDAPK--------DYRQVSLTAVKQRFEDK 520

  Fly   418 QSQHLSQ 424
            :...:||
Human   521 RYGEISQ 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	CYCLIN_SF	144..278	CDD:477360	38/178 (21%)
		CYCLIN_CCND_rpt2	283..387	CDD:410220	19/105 (18%)
CCNF	NP_001752.2	Nuclear localization signal 1. /evidence=ECO:0000269|PubMed:10716937	20..28
		F-box domain	29..76
		F-box_FBXO1	31..82	CDD:438854
		TPR	<88..124	CDD:440553
		CYCLIN_CCNF_rpt1	307..401	CDD:410225	25/100 (25%)
		D box 1. /evidence=ECO:0000269|PubMed:27653696	310..313		1/2 (50%)
		D box 2. /evidence=ECO:0000269|PubMed:27653696	343..346		0/2 (0%)
		D box 3. /evidence=ECO:0000269|PubMed:27653696	349..352		0/2 (0%)
		D box 4. /evidence=ECO:0000269|PubMed:27653696	351..354		1/2 (50%)
		CYCLIN_SF	429..540	CDD:477360	22/114 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..593
		Nuclear localization signal 2. /evidence=ECO:0000269|PubMed:10716937	568..574
		PEST	582..766
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..738
		D box 5. /evidence=ECO:0000269|PubMed:27653696	767..770