Protein Alignment tay and FBRS

DIOPT Version :10

• Sequence 1: NP_573086.2
• Gene: tay / 32547
• FlyBaseID: FBgn0260938
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: NP_001098549.2
• Gene: FBRS / 64319
• HGNCID: 20442
• Length: 980
• Species: Homo sapiens
• Alignment Length: 1022
• Identity: 238/1022 - (23%)
• Similarity: 318/1022 - (31%)
• Gaps: 386/1022 - (37%)

  Fly  1507 SSSPSTLSSSVIQKVISPKGESPCNKDRDSSY--STNIRS--HGASTMLPGASQGIGLGSSFCGI 1567
            :||..:|.:..|....|...|...:.|.|.|:  ||:..|  |||..         |...:...:
Human   214 ASSRHSLEAGYICDAESDLDERVSDDDLDPSFTVSTSKASGPHGAFN---------GNCEAKLSV 269

  Fly  1568 APSQYGGTGTPVLSSSSSMPPGLGNLSSYSSKAALWLNSPANAVVTTCAPTTPIVSSGSARPTPP 1632
            .|...|      |..|...|||               ..|.........|..|.|      |.||
Human   270 VPKVSG------LERSQEQPPG---------------PDPLLVPFPPKEPPPPPV------PRPP 307

  Fly  1633 LSNCTSMGIGMVNAASTARSSCNAISPLSIPATA-----------------GIHVSATNPSFQ-- 1678
            :|                       .|..:|||.                 |:..|....|..
Human   308 VS-----------------------PPAPLPATPSLPPPPQPQLQLRVSPFGLRTSPYGSSLDLS 349

  Fly  1679 -SSSYFPTPLAPPP--SSPSPATSSAAIISSSASQFNPAVSHSMSSIVTTAGATTTTASSVTQPS 1740
             .||..|.|.||.|  :.|.|::||::..|||||..:..::|           ...|.|.....|
Human   350 TGSSSRPPPKAPAPPVAQPPPSSSSSSSSSSSASSSSAQLTH-----------RPPTPSLPLPLS 403

  Fly  1741 VAAISNPVTNTPHPFSAESLFQPSKN----------------------DQADLLRRELDSRFLDR 1783
            ..:...|....|.|....|||.|...                      .:.||:.::|:||:|:.
Human   404 THSFPPPGLRPPPPPHHPSLFSPGPTLPPPPPLLQVPGHPGASAANALSEQDLIGQDLNSRYLNA 468

  Fly  1784 S------GLAVTPTPPSSTYLRTDLQHQQ-HAHLHQH-----PQLLPPVSAP------------- 1823
            .      |...:..|.:..:.:.:.|||. |.|.|||     |.|||| ..|
Human   469 QGGPEVVGAGGSARPLAFQFHQHNHQHQHTHQHTHQHFTPYPPGLLPP-HGPHMFEKYPGKMEGL 532

  Fly  1824 --STPLSAVQPSSGQIFP--PPLFKDISKISSVDPQFYRTGMGLPPGGYSGYTSAGLLHSGLGGP 1884
              ..|.:|..|:...:.|  ||.....|...:..|:  .|...|||  ..|...:||...|...|
Human   533 FRHNPYTAFPPAVPGLPPGLPPAVSFGSLQGAFQPK--STNPELPP--RLGPVPSGLSQKGTQIP 593

  Fly  1885 TPFMPPNHLTSFAPKKTGRWNAMHVRIAWEIYYHQNKQSPEKQ---------PGFPTASSNAGSI 1940
            ..|.||       .:|.|:|.|||||:|:.|..||.|...:..         |..|      |..
Human   594 DHFRPP-------LRKPGKWCAMHVRVAYMILRHQEKMKGDSHKLDFRNDLLPCLP------GPY 645

  Fly  1941 NAPIPPGNMISGGGGGMASGASTPVNNVAAIPAVGGGVLVSNGPPSVLGMKTTPTLGMSSTPQHI 2005
            .| :|||..:           |.|.:...|..||..........|...|    |.|..|:   ||
Human   646 GA-LPPGQEL-----------SHPASLFTATGAVHAAANPFTAAPGAHG----PFLSPST---HI 691

  Fly  2006 --LHRASEMPPSAAFPGGLPGRLAFETSPLAASFI-----GAPPSHIGTAVSPFGR-YVTPFGFT 2062
              ..|.:.....||...|..|.|...|....|.|.     ||||: ..:...|:|| :.:|..|
Human   692 DPFGRPTSFASLAALSNGAFGGLGSPTFNSGAVFAQKESPGAPPA-FASPPDPWGRLHRSPLTF- 754

  Fly  2063 GLTHFGGHLDSWRTNAMQRSVAYHPSSAAPSPNWPVKSDPGLDNARREAEERERELRDREQRERD 2127
                     .:|          ..|..||.:        ||.|
Human   755 ---------PAW----------VRPPEAART--------PGSD---------------------- 770

  Fly  2128 RQRREREERERKEKEEKLKREQQERERERERDRKERERERRE--IERREMERERMLQQQRINESN 2190
                                             |||..||||  |.:.|.:|:....:.::..|.
Human   771 ---------------------------------KERPVERREPSITKEEKDRDLPFSRPQLRVSP 802

  Fly  2191 KQAAVQAAAAATAPVRDRSPHRNVGELNTEIRIKEEHPRTKEEQDVMLLRASAAAVGVGDPRYHS 2255
            .....:|......|.::            .:|:|||.   |||       |:|||.
Human   803 ATPKARAGEEGPRPTKE------------SVRVKEER---KEE-------AAAAAA--------- 836

  Fly  2256 SSLAAAQASAAAAAAHHHHANFMAASRHGL------PPPPSHL--------------TRTMMPPT 2300
               |||.|:||||||        |....||      |.||..|              |....||.
Human   837 ---AAAAAAAAAAAA--------ATGPQGLHLLFERPRPPPFLGPSPPDRCAGFLEPTWLAAPPR 890

  Fly  2301 LS-------VGGPITHFGAPAPPG-WGIDPYRDPYPIL--RYNPIMEAALRHEAEERQKAINIYA 2355
            |:       .|..:|..||.|... :|::|   .:|:|  |..|....|               |
Human   891 LARPPRFYEAGEELTGPGAVAAARLYGLEP---AHPLLYSRLAPPPPPA---------------A 937

  Fly  2356 AQSAAHLRSKEPSPIPPSVGSLGPPPPHHRLQIVSSVAQSGVQQPGP 2402
            |....||.||.|   |.::  ||.|||    .:.:....|..:.|||
Human   938 APGTPHLLSKTP---PGAL--LGAPPP----LVPAPRPSSPPRGPGP 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tay	NP_573086.2	Auts2	1900..>2023	CDD:464656	36/133 (27%)
FBRS	NP_001098549.2	Auts2	602..802	CDD:464656	67/308 (22%)