Protein Alignment tay and FBRSL1

DIOPT Version :10

• Sequence 1: NP_573086.2
• Gene: tay / 32547
• FlyBaseID: FBgn0260938
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_011533105.1
• Gene: FBRSL1 / 57666
• HGNCID: 29308
• Length: 1104
• Species: Homo sapiens
• Alignment Length: 1365
• Identity: 307/1365 - (22%)
• Similarity: 426/1365 - (31%)
• Gaps: 527/1365 - (38%)

  Fly  1310 RSSDSRNSR-ESPAS-LKSTPS----NIGLNVS----MAPTLRSITPLNNSSAISSGASQPVVSV 1364
            |...:|::| :||:| .:..||    |.||..:    .||..|:..|.......||...:.|:.
Human    20 RREAARDARAQSPSSGDEPEPSPGKENAGLRGAPPRGAAPAPRTARPPRRRRRESSSQEEEVID- 83

  Fly  1365 VPSANSTALSMSNPHISHSHHVPAYASGAFSSSAAAGTSTPNSGLSTLAVTSLSTSAAPQPHSHF 1429
                                   .:|..:||:                 :.:|....|.:||...
Human    84 -----------------------GFAIASFST-----------------LEALEKDMALKPHERK 108

  Fly  1430 PQSTQMLPQSGNFSSVSHLLTTHPMS-SQNQPMVRCGS---TLYSQSSAAATAP--PSAAAAVS- 1487
            .:..:.|.:....|.     |..|.. |:|:..:..||   .|......|...|  ||....|:
Human   109 EKWERRLIKKPRESE-----TCPPAEPSENRRPLEAGSPGQDLEPACDGARKVPLQPSKQMKVTV 168

  Fly  1488 -------NFTPSVLAVQSLTTAVTSSSSSPSTLSSSVIQKVISPKGESPCNKDRDSSYSTNIRSH 1545
                   :...|||.        .:||..|.:.||:   ..:|.:|.| |:.:.......::.|.
Human   169 SKGGDRDSDDDSVLE--------ATSSRDPLSDSSA---HAVSGRGYS-CDSESGPDDKASVGSE 221

  Fly  1546 GASTMLPGASQGIGLGSS--FCGIAPSQYGGTGTPVLSSSSSMPPGLGNLSSYSSKAALWLNSP- 1607
              ....||..:|..|..|  ..|..|...|...:..||:.|.:|     .:|.:..||.....|
Human   222 --KLFAPGTDKGPALEKSEAKAGPVPKVSGLERSRELSAESFLP-----TASPAPHAAPCPGPPP 279

  Fly  1608 ---ANAVVTTCAPT----TPIVSSGSARPTPP-----LSNCTSMGIGMVNAASTARSSCNAISPL 1660
               ||.:|....|.    ||       :|.||     |.......:|..  |..::::.|.:..|
Human   280 GSRANPLVKKEPPAPHRHTP-------QPPPPQPRGLLPTHVPASLGAF--AGHSQAAANGLHGL 335

  Fly  1661 ----SIPATAGIHVSATNPSFQSSSYFPTPLAPPPSSPSPATSSAAIISSSASQFNPAVSHSMSS 1721
                |.|...|.|||               |:|....|..:||..|:.|.:..|.:.|:   .::
Human   336 SRSSSAPLGLGKHVS---------------LSPHGPGPHLSTSHLALRSQAQHQLHAAM---FAA 382

  Fly  1722 IVTTAGATTTTASSVTQPSVAAISNPVTNTPHPFSAE---SLFQPSKNDQA--------DLLRRE 1775
            ..|........|||:..|.            ||..|.   |..||....|.        :|||:|
Human   383 PPTLPPPPALPASSLVLPG------------HPADASLAVSFSQPIMYCQPHSGILIDHELLRQE 435

  Fly  1776 LDSRFL----DRSGLAVTPTPPSSTYLRTDL-QHQ-------QHAHLHQHPQLLPPVSAPSTPLS 1828
            |::|||    :|.|.::.|    ...||.:. |||       ||.|.|||.....|...|.||.:
Human   436 LNTRFLVQSAERPGASLGP----GALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTPPA 496

  Fly  1829 AVQPSSGQIFPPPLFKDISKI-------SSVD---------------------PQFYRTGMGLP- 1864
            |         |||..|...|:       |||.                     |.|.....|||
Human   497 A---------PPPFDKYAPKLDSPYFRHSSVSAEGGVRTWAPPPSALLLLQFFPSFPPAIPGLPT 552

  Fly  1865 -----------PGGYSGYTS--------AGLLHSGL----GGPTPFMPPNHLTSFAPKKTGRWNA 1906
                       .|.:...||        ||.:|:.|    |...|:..       ..||.|||.|
Human   553 LLPHPGPFGSLQGAFQPKTSSPIEVARRAGAVHTLLQKAPGVSDPYRA-------VVKKPGRWCA 610

  Fly  1907 MHVRIAWEIYYHQNK-----QSPEK-----------------------------QPGFPTASS-- 1935
            :||:|||:||.||.|     ..|.|                             :|.||:...
Human   611 VHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGHAR 675

  Fly  1936 ------NAGSINAP--------------------IPPGNMISGGGGGMASGASTPVNNVAAIPAV 1974
                  :.|:..||                    :||            .||:.|.:|... |:.
Human   676 EWEVKVHRGNWGAPCEQSCRWEALVLSPGFCQTWLPP------------PGAAHPASNPFG-PSA 727

  Fly  1975 GGGVLVSNGP-------PSVLGMKTTPTLGMSSTPQHILHRASEMPPSAAFPGGL------PGRL 2026
            ..|..:..||       ||..|       |:.|...|            || |||      ||..
Human   728 HPGSFLPTGPLTDPFSRPSTFG-------GLGSLSSH------------AF-GGLGSHALAPGGS 772

  Fly  2027 AFETSPLAASFI-GAPPSHIGTAVSPFGRYVTPFGFTGLTHFGGHLDSWRTNAMQRSVAYHPSSA 2090
            .|  :|...|.: |.|..|                           ::|  |.:.|:   .||..
Human   773 IF--APKEGSSVHGLPSPH---------------------------EAW--NRLHRA---PPSFP 803

  Fly  2091 APSPNWPVKSDPGLDNARREAEERERELRDREQRERDRQRREREERERKEKEEKLKRE------- 2148
            ||.| ||...|          .||...|.:.: ||.| ..:|.:||:..||...|.|.
Human   804 APPP-WPKSVD----------AERVSALTNHD-REPD-NGKEEQERDLLEKTRLLSRASPATPAG 855

  Fly  2149 --------QQERERERERDRKERERERREIERREMERERMLQQQRINESNKQAAVQAAAAATAPV 2205
                    :.:.|..|.....|||.|.|..|.|...:|.                    ||..|.
Human   856 HPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEE--------------------AAKMPA 900

  Fly  2206 RDRSPHRNVGELNTEIRIKEEHPRTKEEQDVMLLRASAAAVGVGDPRYHSSSLAAAQASAAAAAA 2270
            |...||.....  .::::|||  |.::|       ||....|
Human   901 RASPPHSKAAP--GDVKVKEE--RGEDE-------ASEPPAG----------------------- 931

  Fly  2271 HHHHANFMAASRHGLPPPPSHL----TRTMMP-----PTLSVGGPITHFGAPAP-PGWGI----- 2320
                         ||.|.|..|    .|...|     |...:..|...|.|.|| ||...
Human   932 -------------GLHPAPLQLGLGRERLGAPGFAWEPFRGLELPRRAFPAAAPAPGSAALLEPP 983

  Fly  2321 -DPYRDPYPILRYNPIMEAALRHEAEERQKAINIYAAQ-----------SAAHLRSKEPSPI--- 2370
             .||||..| ..|:|   ..||.|. ||.:|.::..|.           .|.|.....|:.:
Human   984 ERPYRDREP-HGYSP---ERLRGEL-ERARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNG 1043

  Fly  2371 -----PPSVGSLGPPPPHHRLQIVSSVAQSGVQQPGPPSQQQQQQMSSGGGMVKNSGGPQAPGSI 2430
                 ||:..:||.|||     :|:  |......||||..:.......|.|..::....:.|..:
Human  1044 LLARTPPAAAALGAPPP-----LVT--AAGPPTPPGPPRSRTTPLGGLGPGEARDYSPSRNPPEV 1101

  Fly  2431  2430
            Human  1102  1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tay	NP_573086.2	Auts2	1900..>2023	CDD:464656	44/197 (22%)
FBRSL1	XP_011533105.1	Auts2	604..850	CDD:464656	76/325 (23%)