Protein Alignment tay and Auts2

DIOPT Version :10

• Sequence 1: NP_573086.2
• Gene: tay / 32547
• FlyBaseID: FBgn0260938
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_063127358.1
• Gene: Auts2 / 304419
• RGDID: 2323959
• Length: 1268
• Species: Rattus norvegicus
• Alignment Length: 1568
• Identity: 339/1568 - (21%)
• Similarity: 496/1568 - (31%)
• Gaps: 615/1568 - (39%)

  Fly  1119 GSNNGSANGQGQLSSVGLSSTSEIAKSNSVPTTSSPPNPMVNGFLSVYPPPAATIATSSVTTSAL 1183
            |:..|...|:.:..|:..||.|: .:.|..|.:|:|..|.         ||...
  Rat    33 GAAGGIGTGRTRAPSLASSSGSD-KEDNGKPPSSAPSRPR---------PPRRK----------- 76

  Fly  1184 SRVSPNAANKLVPPVSATTSISINTNYVGISGGTTTTSGMGKVVFGAGGNAIVGTGSPLLFPGAP 1248
            .|.|.:|...::...:.|:.:              |...:.|.|.......:....:||
  Rat    77 RRESTSAEEDIIDGFAMTSFV--------------TFEALEKDVAVKPQERVEKRQNPL------ 121

  Fly  1249 PAPISHVATGVPMIIQAPPYRAPYTNYPLYTPYSGLTHGSYLPPVLPVATPNLSNLPPTQHRSSD 1313
                            ....|...||        ||:..|           ..|.|..:.|.|||
  Rat   122 ----------------TKKKREALTN--------GLSFHS-----------KKSRLSHSHHYSSD 151

  Fly  1314 SRNSRESPASLKSTPSNIGLNVSMAPTLRSITPLNNS-----SAISSGASQPVVSVVPSANSTAL 1373
            ..|.|       :...::|....|...:|.:.|..||     |..:||.|:          ....
  Rat   152 RENDR-------NLCQHLGKRKKMPKGVRQLKPGQNSCRDSDSESASGESK----------GFQR 199

  Fly  1374 SMSNPHISHSHHVPAYASGAFSSSAA-------------------------------------AG 1401
            |.|...:|.|....:..:|.|..|.:                                     ||
  Rat   200 SSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVLVNKDPELGVGALPEHNQDAG 264

  Fly  1402 TSTPN-SGLSTLAVTSLSTSAAP--------QPHSHFPQSTQMLPQSGNFSSVSHLLTTHPMSSQ 1457
            ...|. |||......|......|        .||...||.                    |...|
  Rat   265 PIVPKISGLERSQEKSQDCCKEPVFEPVVLKDPHPQLPQL--------------------PSQPQ 309

  Fly  1458 NQPMVRCGS---TLYSQSSAAATAPPSAAAAVSNFTPSVLAVQSLTTAVTSSSSSPSTLSSSVIQ 1519
            .:|.::..|   .|..::.|....||          ||.........|....:..|.      :|
  Rat   310 AEPQLQIPSPDPNLVPRTEAPPQFPP----------PSTQPAPGPPEAQLQPAPLPQ------VQ 358

  Fly  1520 KVISPKGESPCNKDRDSSYSTNIRSHGASTMLPGASQGIGLGSSFCGIAPSQYGGTGTPVLSSSS 1584
            :  .|:.:||              ||.....||.....          .|||           |.
  Rat   359 R--PPRPQSP--------------SHLLQQTLPPVQSH----------PPSQ-----------SL 386

  Fly  1585 SMPPGLGNLSSYSSKAALWLNSPANAVVTTCAPTTPIVSSGSARPTPP-LSNCTSMGIGMVNAAS 1648
            |.|     ||:|:| ::|.|||.:::..:|.|.|         :|.|| :|:..|        ||
  Rat   387 SQP-----LSAYNS-SSLSLNSLSSSRSSTPAKT---------QPAPPHISHHPS--------AS 428

  Fly  1649 TARSSCNAISPLSIPATAGIHVSATNPSFQ--SSSYFPTPLAPPPSSPSPATSSAAIISSSASQF 1711
            .        .|||:|..:.:|  :..|:.|  :.|..|...|||.:.|.|
  Rat   429 P--------FPLSLPNHSPLH--SFTPTLQPPAHSQHPNMFAPPTALPPP--------------- 468

  Fly  1712 NPAVSHSMSSIVTTAGATTTTASSVTQPSVAAISNPVTNTPHPFSAESLFQPSKNDQADLLRREL 1776
             |.:                |:.|:..|.            ||..       |...:.|:||:||
  Rat   469 -PPL----------------TSGSLQVPG------------HPAG-------STYSEQDILRQEL 497

  Fly  1777 DSRFL-----DRSGLAVTPTPPSSTYLRTDL-QHQ-QHAHLHQH---------PQLLPPVSAPST 1825
            ::|||     || |.::.|.|    ||||:. ||| ||.|.|||         |..:||.:...|
  Rat   498 NTRFLASQSADR-GASLGPPP----YLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPT 557

  Fly  1826 PLSAVQPSSGQIFPP-PLFKDISKISSVDPQFYRTGM---------GLPP------------GGY 1868
            |...:..:.|:.|.. |        :.||| |||..:         |:||            |.:
  Rat   558 PAPPMVRTPGRNFDKYP--------TKVDP-FYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAF 613

  Fly  1869 SGYTSAGLLHSGLGGPTPF----MPPNHLTSFAP--KKTGRWNAMHVRIAWEIYYHQNK------ 1921
            ...||..:..:...|..|.    ..|.....|.|  :|.|:|.||||.|||:||:||.|
  Rat   614 QPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQ 678

  Fly  1922 QSPEK-----QPGF---PTASSNAGSINAP---IPPGNMISGGGGGMASGASTPVN--------- 1966
            ..|.|     :|.|   |...|..|:|:.|   ..|..:.|..|....:|  ||..
  Rat   679 SDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTG--TPFGPPPHHSNFL 741

  Fly  1967 NVAA-------------IPAVGGGVLVSNG-----PPSVLGMKTTPTLGMSSTPQHILHRASEMP 2013
            |.||             :.||||......|     |.||.|.|.:|::...|.|....:|....|
  Rat   742 NPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTP 806

  Fly  2014 PSAAFPGG--LPGRLAFETSPLAASF-----IGAPPSHIGTAVSPFGRYVTPFGFTGLTHFGGHL 2071
            ||...|..  .||.|  |.|..||:.     :....|.:...
  Rat   807 PSFPTPPPWLKPGEL--ERSASAAAHDRDRDVDKRDSSVSKD----------------------- 846

  Fly  2072 DSWRTNAMQRSVAYHPSSAAPSPNWPVKSDPGLDNARREAEERERELRDREQRERDRQRREREER 2136
            |..|.:..:|    |||..:|:|..||.:   |.:.|...:...|...:.|.||:|:.:
  Rat   847 DKERESVEKR----HPSHPSPAPPVPVSA---LGHNRSSTDPTTRGHLNTEAREKDKPK------ 898

  Fly  2137 ERKEKEEKLKREQQERERERERDRKERERERREIERREM-ERERMLQQQR-INESNKQAA----- 2194
                          ||||:....||:...|..:.:...: ||:....:.| ..|..||.:
  Rat   899 --------------ERERDHSGSRKDLTTEEHKAKEGHLPERDGHSHEGRAAGEEPKQLSRVPSP 949

  Fly  2195 ------VQAAAAATAPVRDRSPHRNVGE-------LNTEIRIKEEHPRTKEEQDVMLLRASAAAV 2246
                  |.:....:...|:..|.:  ||       .|.|:::|||.   ||:.|   |...|
  Rat   950 YVRTPGVDSTRPNSTSSREAEPRK--GEPAYENPKKNAEVKVKEER---KEDHD---LPTEA--- 1003

  Fly  2247 GVGDPRYHSSSLAAAQASAAAAAAHH---------------HHANFMAASRHGLPPPPSHLTRT- 2295
                |:.|.:|.|...:|:|:|:.|.               |..|.:.:           |.||
  Rat  1004 ----PQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGS-----------LDRTR 1053

  Fly  2296 MMPPTLSVGGPITHFGAPAPPG---------WG--IDPYRDPYPIL---RYNPI-MEAALRHEAE 2345
            ||.|.:.:        :|.|.|         |.  .||.||||..|   |.:|: .:..||::..
  Rat  1054 MMTPFMGL--------SPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPL 1110

  Fly  2346 ERQKAINIYAA-------------------------------QSAAHLRSKE------------- 2366
            .|.....:|.|                               :...||..:|
  Rat  1111 HRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPR 1175

  Fly  2367 -----PSPIP-----PSVGSLGPPPPHHRLQIVSSVAQSGVQQPGPPSQQQQQQMSSGGGMVKNS 2421
                 |:.:.     ||:.:.|.|..|:.....::..|:|:....||:    ..:|:...::...
  Rat  1176 LHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPT----AALSAPPPLISTL 1236

  Fly  2422 GGPQAPGS 2429
            ||  .|||
  Rat  1237 GG--RPGS 1242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tay	NP_573086.2	Auts2	1900..>2023	CDD:464656	51/168 (30%)
Auts2	XP_063127358.1	None