Protein Alignment Chc and CLTCL1

DIOPT Version :10

• Sequence 1: NP_477042.1
• Gene: Chc / 32537
• FlyBaseID: FBgn0000319
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: NP_009029.3
• Gene: CLTCL1 / 8218
• HGNCID: 2093
• Length: 1640
• Species: Homo sapiens
• Alignment Length: 1629
• Identity: 1260/1629 - (77%)
• Similarity: 1452/1629 - (89%)
• Gaps: 1/1629 - (0%)

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.||:|||||.||.|:|||..:..|||||||||||||:||||.:.|||.||||:|...|.|||
Human     1 MAQILPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMAPIRRP 65

  Fly    66 ISADSAIMNPASKVIALKAQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFHW 130
            |||:|||||||||||||||.|||||||||||||||||||.|:|:||||:|:||:||||||:|:||
Human    66 ISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVTETAVYHW 130

  Fly   131 SMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAIE 195
            ||||||.|.||||||:||.|||:|:||.:..|:|||||||||..:||.||||||||:|||||.||
Human   131 SMEGDSQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIE 195

  Fly   196 GHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQNDF 260
            ||||:||.||::.|.:|.||||||||..|||||||||||.|..|||||.||||||||||||||||
Human   196 GHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDF 260

  Fly   261 PVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQVL 325
            |||||:.||:..|||||||||:||||:|:..||.|||||||||||||||:.:.||||||:|||||
Human   261 PVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVL 325

  Fly   326 SVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPKA 390
            ||.|:|:.|:.|...|||||||.||:|||:||||||.|||||||.||..|.|||||||||.|||.
Human   326 SVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKG 390

  Fly   391 ILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLKE 455
            ||||.:|:|:||.:...:|..: |||||||||||||:|||.||||||..||.||:|||.||||||
Human   391 ILRTRETVQKFQSIPAQSGQAS-PLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKE 454

  Fly   456 EKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLLR 520
            :|||||||||||||.:|..||||:|||||||:||||||||||||||||||||||.||||::||||
Human   455 DKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLR 519

  Fly   521 SVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTRL 585
            .||:.:||||..|:.|||.:|||||:|:||||||||:|::||||:|||||||:||||||.|||.|
Human   520 GVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWL 584

  Fly   586 LEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNAE 650
            |||||:.|||||||||||.|||||||||||||||||||||:|||||||||||||||||||:||.|
Human   585 LEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPE 649

  Fly   651 WLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFYF 715
            |||:|||:||||||:|||.|||:||:|||||:|||:|:||||||..:||::|||.||||.|||||
Human   650 WLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYF 714

  Fly   716 LSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVCD 780
            |.|||||||||:||.|||||||||.||||||||||||:|||||||||||||||||||||||||||
Human   715 LGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCD 779

  Fly   781 RFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTDE 845
            ||.|||||||||||||||:|||||||||||||.|.|:||||||||||::||:||:.|:|||||||
Human   780 RFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDE 844

  Fly   846 LVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVVGRYC 910
            ||.|||||||||||||||||::.|||.|||||||||||||||||:||.:|:||.||||.||||||
Human   845 LVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYC 909

  Fly   911 EKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQLIDQV 975
            |||||||||||||||.||.|||.||||||||||||||||.|:|.||||.||.|:||.:|||||||
Human   910 EKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQV 974

  Fly   976 VQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKADRTR 1040
            ||||||||:||::||||||||||||||||||||||||:||:||||:|||||||||||||||||||
Human   975 VQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTR 1039

  Fly  1041 VMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCNE 1105
            ||:||:||:||||.|||:||:|:.||||||.:|.|||:|.|||||||:.:.||:||.||||||||
Human  1040 VMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNE 1104

  Fly  1106 PAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESYI 1170
            ||||||||:||||:.||||||:|||:.||||:|::||..||:..:|:|||::|||||||.|||||
Human  1105 PAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYI 1169

  Fly  1171 ESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVYL 1235
            |:|||:|.|:|.|:::||:||:|||:|.||::|:||:.:|||:||||||:|||||||||.|||:|
Human  1170 ETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHL 1234

  Fly  1236 KEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDEL 1300
            .|:|.|||::|||:||||||||||||:|.:|||.||:||||||:||||||:|:.|||:||||:||
Human  1235 GEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEEL 1299

  Fly  1301 IALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVFL 1365
            |.|||:||||||||||||||||||||||||.||.||||||||||||||||||||.||||:|||||
Human  1300 ILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFL 1364

  Fly  1366 YDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAPR 1430
            ||||||||||||.||:||||||:||.||||||||||:||.|:|::||||:||||:||:||||:||
Human  1365 YDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPR 1429

  Fly  1431 MDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNIA 1495
            :|||..||:|||.|.|||||||||||||.|||::|||||.||.:||||||||.|||.:||||||:
Human  1430 LDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNIS 1494

  Fly  1496 LAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFLE 1560
            |||:||||:|.|||.||||||||||.|.|||||||||.||||||::||||...::|::||.||||
Human  1495 LAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLE 1559

  Fly  1561 RDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQREKED 1625
            ....:||||||:.||||||||::|||||:|.:||.||||.|||:|||.:|||||:..|:.|::|:
Human  1560 EGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEE 1624

  Fly  1626 DSTE 1629
            ..||
Human  1625 HVTE 1628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_477042.1	Clathrin_propel	19..56	CDD:460192	26/36 (72%)
		Clathrin_propel	148..187	CDD:460192	26/38 (68%)
		Clathrin_propel	198..234	CDD:460192	25/35 (71%)
		Clathrin_propel	256..288	CDD:460192	25/31 (81%)
		Clathrin_propel	296..330	CDD:460192	27/33 (82%)
		Clathrin-link	331..354	CDD:462732	13/22 (59%)
		Clathrin_H_link	356..422	CDD:463995	44/65 (68%)
		CLH	542..672	CDD:128594	110/129 (85%)
		CLH	687..825	CDD:128594	119/137 (87%)
		CLH	834..969	CDD:128594	110/134 (82%)
		CLH	980..1118	CDD:128594	111/137 (81%)
		Clathrin	1129..1268	CDD:459884	92/138 (67%)
		CLH	1275..1417	CDD:128594	119/141 (84%)
		Clathrin	1429..1562	CDD:459884	99/132 (75%)
CLTCL1	NP_009029.3	Globular terminal domain	2..479		354/477 (74%)
		Clathrin_propel	19..55	CDD:460192	25/35 (71%)
		WD40-like repeat 1	24..67		29/42 (69%)
		WD40-like repeat 2	68..107		35/38 (92%)
		WD40-like repeat 3	108..149		31/40 (78%)
		WD40-like repeat 4	150..195		31/44 (70%)
		WD40-like repeat 5	196..257		46/60 (77%)
		Clathrin_propel	198..234	CDD:460192	25/35 (71%)
		Clathrin_propel	256..288	CDD:460192	25/31 (81%)
		WD40-like repeat 6	258..301		31/42 (74%)
		Clathrin_propel	296..330	CDD:460192	27/33 (82%)
		WD40-like repeat 7	302..330		21/27 (78%)
		Clathrin-link	331..354	CDD:462732	13/22 (59%)
		Clathrin_H_link	356..421	CDD:463995	44/65 (68%)
		Binding site for the uncoating ATPase, involved in lattice disassembly. /evidence=ECO:0000255	449..465		14/15 (93%)
		Flexible linker	480..523		37/42 (88%)
		Heavy chain arm	524..1640		866/1105 (78%)
		Distal segment	524..634		88/109 (81%)
		CLH	541..674	CDD:128594	112/132 (85%)
		Proximal segment	639..1640		772/990 (78%)
		CLH	686..824	CDD:128594	119/137 (87%)
		CLH	833..960	CDD:128594	105/126 (83%)
		CLH	979..1119	CDD:128594	113/139 (81%)
		Clathrin	1128..1267	CDD:459884	92/138 (67%)
		Involved in binding clathrin light chain. /evidence=ECO:0000250	1213..1522		248/308 (81%)
		CLH	1274..1416	CDD:128594	119/141 (84%)
		Clathrin	1427..1564	CDD:459884	99/136 (73%)
		Trimerization. /evidence=ECO:0000250	1551..1640		48/78 (62%)