Protein Alignment Chc and Cltc

DIOPT Version :10

• Sequence 1: NP_477042.1
• Gene: Chc / 32537
• FlyBaseID: FBgn0000319
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: XP_006534046.1
• Gene: Cltc / 67300
• MGIID: 2388633
• Length: 1683
• Species: Mus musculus
• Alignment Length: 1672
• Identity: 1335/1672 - (79%)
• Similarity: 1506/1672 - (90%)
• Gaps: 13/1672 - (0%)

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.|||||||||||.|:|||..:..|||||||||||||:||||.:.||||||||||.:||.|||
Mouse     1 MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRP 65

  Fly    66 ISADSAIMNPASKVIALK-AQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFH 129
            |||||||||||||||||| |.|||||||||||||||||||.:||.|||||||||:||||:.:|:|
Mouse    66 ISADSAIMNPASKVIALKDAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYH 130

  Fly   130 WSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAI 194
            |||||:|.|.|||||||||.||||||||.:|.|:||||.||||..:||.||||||||:|||||.|
Mouse   131 WSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPI 195

  Fly   195 EGHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQND 259
            ||||||||.||::.|.|.:||||||||...||||||||||.||.|||||.|||||||||||||||
Mouse   196 EGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQND 260

  Fly   260 FPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQV 324
            ||||||:|.|:|.::||||||||||||:||.|||||||||.:||||||||||:.|||||||||||
Mouse   261 FPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQV 325

  Fly   325 LSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPK 389
            |||.|:||.|||||..|||||||||||||||||||||:||.||||.||..|.|:|||||||.|||
Mouse   326 LSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPK 390

  Fly   390 AILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLK 454
            .|||||.||:|||.|....|.|: |||||||||||||:|||:||||||||||.||:|||.|||||
Mouse   391 GILRTPDTIRRFQSVPAQPGQTS-PLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLK 454

  Fly   455 EEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLL 519
            |:|||||||||||||:.|.|||||:|||||||||||||||||||.||||||||||.||||::|||
Mouse   455 EDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLL 519

  Fly   520 RSVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTR 584
            |:|||.:|:||..||.|||.:|||||||.||||:|||::::||||||||||||:|||:||.||||
Mouse   520 RNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTR 584

  Fly   585 LLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNA 649
            |||||||.|||||||||||.||||||||||||||||||||||||||:||||||||||||||:||.
Mouse   585 LLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNP 649

  Fly   650 EWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFY 714
            ||||::||:||||||||||:|||:||:|||||||||:|:||||||:.::||:|||.|||::||||
Mouse   650 EWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFY 714

  Fly   715 FLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVC 779
            ||.|||||||||:||||||||||||.|||||||||||||||:|||||||||||||||||||||||
Mouse   715 FLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVC 779

  Fly   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTD 844
            |||||||||||||||||||||||||||||||||||||:|||||||||||:||||||||:||||||
Mouse   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTD 844

  Fly   845 ELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVVGRY 909
            |||.||||||||||||||||:|:||||.|||||||||||||||||||||:|:||.||||||||:|
Mouse   845 ELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKY 909

  Fly   910 CEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQLIDQ 974
            ||||||||||||||||.||.|||.||||||||||.:||||.|:|.|||..||.|||||:|.||||
Mouse   910 CEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQ 974

  Fly   975 VVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKADRT 1039
            ||||||||||||:::|||||||||||||||||||||||:||:||||:||||||||||||||||||
Mouse   975 VVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRT 1039

  Fly  1040 RVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCN 1104
            |||:|||||:||||||||||||||:|:|||||||:||||||||:||||:.:.||:||.|||||||
Mouse  1040 RVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCN 1104

  Fly  1105 EPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESY 1169
            ||||||||||||||:|:|||||||||||||||:|::||..|:...:|::||:|||||||||||||
Mouse  1105 EPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANASGNWEELVKYLQMARKKARESY 1169

  Fly  1170 IESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVY 1234
            :|:|||:|.|:|.|||:|||||:|||:|.||::|:||:.:.|||||||||||||||.|||.|||:
Mouse  1170 VETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVH 1234

  Fly  1235 LKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDE 1299
            |.|:|.|||.|||||||||||||||||||.:||||||||||||||||||||:||||||:||||:|
Mouse  1235 LGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEE 1299

  Fly  1300 LIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVF 1364
            ||.:||:||||||||||||||||||||||||.|||||||||||||||||||||||.||||:||||
Mouse  1300 LITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVF 1364

  Fly  1365 LYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAP 1429
            |||||||||||::.||.|||:||:||.||||||||||:|||||||:|||:||||||||:|:||:|
Mouse  1365 LYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFKPLLLNDLLMVLSP 1429

  Fly  1430 RMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNI 1494
            |:||||||:||||...||||||||||||:.|||::||:||.|.|.|||||.||.|||.:||||||
Mouse  1430 RLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNI 1494

  Fly  1495 ALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFL 1559
            :|||:||||||.|||||||||:||||||||||||||||.||||||:||:||...::|||||.|||
Mouse  1495 SLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFL 1559

  Fly  1560 ERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTT-------KVDKLELN 1617
            :.:..:||.|||:.|||||||||:||.||:|.|:||||||.|||::||.|       |||||:.:
Mouse  1560 QEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDAIKEKVDKLDAS 1624

  Fly  1618 EAQREKEDDSTEHKNIIQMEPQLMITAGPAMGIPPQ----YAQNYPP 1660
            |:.|::|:.:||.:.|:..:||||:||||::.:|||    |....||
Mouse  1625 ESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPP 1671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_477042.1	Clathrin_propel	19..56	CDD:460192	27/36 (75%)
		Clathrin_propel	148..187	CDD:460192	28/38 (74%)
		Clathrin_propel	198..234	CDD:460192	25/35 (71%)
		Clathrin_propel	256..288	CDD:460192	25/31 (81%)
		Clathrin_propel	296..330	CDD:460192	28/33 (85%)
		Clathrin-link	331..354	CDD:462732	19/22 (86%)
		Clathrin_H_link	356..422	CDD:463995	46/65 (71%)
		CLH	542..672	CDD:128594	111/129 (86%)
		CLH	687..825	CDD:128594	123/137 (90%)
		CLH	834..969	CDD:128594	114/134 (85%)
		CLH	980..1118	CDD:128594	119/137 (87%)
		Clathrin	1129..1268	CDD:459884	99/138 (72%)
		CLH	1275..1417	CDD:128594	122/141 (87%)
		Clathrin	1429..1562	CDD:459884	101/132 (77%)
Cltc	XP_006534046.1	Clathrin_propel	19..56	CDD:460192	27/36 (75%)
		Clathrin_propel	149..188	CDD:460192	28/38 (74%)
		Clathrin_propel	199..235	CDD:460192	25/35 (71%)
		Clathrin_propel	257..289	CDD:460192	25/31 (81%)
		Clathrin_propel	297..331	CDD:460192	28/33 (85%)
		Clathrin-link	332..355	CDD:462732	19/22 (86%)
		Clathrin_H_link	357..422	CDD:463995	46/65 (71%)
		CLH	542..675	CDD:128594	113/132 (86%)
		CLH	687..825	CDD:128594	123/137 (90%)
		CLH	834..969	CDD:128594	114/134 (85%)
		CLH	980..1119	CDD:128594	120/138 (87%)
		TPR repeat	1106..1132	CDD:276809	23/25 (92%)
		CLH	1129..1266	CDD:128594	98/136 (72%)
		CLH	1275..1417	CDD:128594	122/141 (87%)
		Clathrin	1428..1565	CDD:459884	101/136 (74%)