Protein Alignment Chc and Cltc

DIOPT Version :10

• Sequence 1: NP_477042.1
• Gene: Chc / 32537
• FlyBaseID: FBgn0000319
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: XP_006247170.1
• Gene: Cltc / 54241
• RGDID: 2364
• Length: 1682
• Species: Rattus norvegicus
• Alignment Length: 1671
• Identity: 1334/1671 - (79%)
• Similarity: 1506/1671 - (90%)
• Gaps: 12/1671 - (0%)

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.|||||||||||.|:|||..:..|||||||||||||:||||.:.||||||||||.:||.|||
  Rat     1 MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRP 65

  Fly    66 ISADSAIMNPASKVIALKAQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFHW 130
            |||||||||||||||||||.|||||||||||||||||||.:||.|||||||||:||||:.:|:||
  Rat    66 ISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHW 130

  Fly   131 SMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAIE 195
            ||||:|.|.|||||||||.||||||||.:|.|:||||.||||..:||.||||||||:|||||.||
  Rat   131 SMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIE 195

  Fly   196 GHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQNDF 260
            |||||||.||::.|.|.:||||||||...||||||||||.||.|||||.||||||||||||||||
  Rat   196 GHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDF 260

  Fly   261 PVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQVL 325
            |||||:|.|:|.::||||||||||||:||.|||||||||.:||||||||||:.||||||||||||
  Rat   261 PVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVL 325

  Fly   326 SVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPKA 390
            ||.|:||.|||||..|||||||||||||||||||||:||.||||.||..|.|:|||||||.|||.
  Rat   326 SVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKG 390

  Fly   391 ILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLKE 455
            |||||.||:|||.|....|.|: |||||||||||||:|||:||||||||||.||:|||.||||||
  Rat   391 ILRTPDTIRRFQSVPAQPGQTS-PLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKE 454

  Fly   456 EKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLLR 520
            :|||||||||||||:.|.|||||:|||||||||||||||||||.||||||||||.||||::||||
  Rat   455 DKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLR 519

  Fly   521 SVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTRL 585
            :|||.:|:||..||.|||.:|||||||.||||:|||::::||||||||||||:|||:||.|||||
  Rat   520 NVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRL 584

  Fly   586 LEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNAE 650
            ||||||.|||||||||||.||||||||||||||||||||||||||:||||||||||||||:||.|
  Rat   585 LEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPE 649

  Fly   651 WLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFYF 715
            |||::||:||||||||||:|||:||:|||||||||:|:||||||:.::||:|||.|||::|||||
  Rat   650 WLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYF 714

  Fly   716 LSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVCD 780
            |.|||||||||:||||||||||||.|||||||||||||||:||||||||||||||||||||||||
  Rat   715 LGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCD 779

  Fly   781 RFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTDE 845
            |||||||||||||||:||||||||||||||||||||:|||||||||||:||||||||:|||||||
  Rat   780 RFDFVHDLVLYLYRNSLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDE 844

  Fly   846 LVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVVGRYC 910
            ||.||||||||||||||||:|:||||.|||||||||||||||||||||:|:||.||||||||:||
  Rat   845 LVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYC 909

  Fly   911 EKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQLIDQV 975
            |||||||||||||||.||.|||.||||||||||.:||||.|:|.|||..||.|||||:|.|||||
  Rat   910 EKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQV 974

  Fly   976 VQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKADRTR 1040
            |||||||||||:::|||||||||||||||||||||||:||:||||:|||||||||||||||||||
  Rat   975 VQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTR 1039

  Fly  1041 VMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCNE 1105
            ||:|||||:||||||||||||||:|:|||||||:||||||||:||||:.:.||:||.||||||||
  Rat  1040 VMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNE 1104

  Fly  1106 PAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESYI 1170
            |||||||||||||:|:|||||||||||||||:|::||..|:...:|::||:|||||||||||||:
  Rat  1105 PAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYV 1169

  Fly  1171 ESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVYL 1235
            |:|||:|.|:|.|||:|||||:|||:|.||::|:||:.:.|||||||||||||||.|||.|||:|
  Rat  1170 ETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHL 1234

  Fly  1236 KEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDEL 1300
            .|:|.|||.|||||||||||||||||||.:||||||||||||||||||||:||||||:||||:||
  Rat  1235 GEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEEL 1299

  Fly  1301 IALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVFL 1365
            |.:||:||||||||||||||||||||||||.|||||||||||||||||||||||.||||:|||||
  Rat  1300 ITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFL 1364

  Fly  1366 YDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAPR 1430
            ||||||||||::.||.|||:||:||.||||||||||:|||||||:|||:||||||||:|:||:||
  Rat  1365 YDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFKPLLLNDLLMVLSPR 1429

  Fly  1431 MDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNIA 1495
            :||||||:||||...||||||||||||:.|||::||:||.|.|.|||||.||.|||.:||||||:
  Rat  1430 LDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNIS 1494

  Fly  1496 LAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFLE 1560
            |||:||||||.|||||||||:||||||||||||||||.||||||:||:||...::|||||.|||:
  Rat  1495 LAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQ 1559

  Fly  1561 RDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTT-------KVDKLELNE 1618
            .:..:||.|||:.|||||||||:||.||:|.|:||||||.|||::||.|       |||||:.:|
  Rat  1560 EEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDAIKEKVDKLDASE 1624

  Fly  1619 AQREKEDDSTEHKNIIQMEPQLMITAGPAMGIPPQ----YAQNYPP 1660
            :.|::|:.:||.:.|:..:||||:||||::.:|||    |....||
  Rat  1625 SLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPP 1670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_477042.1	Clathrin_propel	19..56	CDD:460192	27/36 (75%)
		Clathrin_propel	148..187	CDD:460192	28/38 (74%)
		Clathrin_propel	198..234	CDD:460192	25/35 (71%)
		Clathrin_propel	256..288	CDD:460192	25/31 (81%)
		Clathrin_propel	296..330	CDD:460192	28/33 (85%)
		Clathrin-link	331..354	CDD:462732	19/22 (86%)
		Clathrin_H_link	356..422	CDD:463995	46/65 (71%)
		CLH	542..672	CDD:128594	111/129 (86%)
		CLH	687..825	CDD:128594	122/137 (89%)
		CLH	834..969	CDD:128594	114/134 (85%)
		CLH	980..1118	CDD:128594	119/137 (87%)
		Clathrin	1129..1268	CDD:459884	99/138 (72%)
		CLH	1275..1417	CDD:128594	122/141 (87%)
		Clathrin	1429..1562	CDD:459884	101/132 (77%)
Cltc	XP_006247170.1	Clathrin_propel	19..56	CDD:460192	27/36 (75%)
		Clathrin_propel	148..187	CDD:460192	28/38 (74%)
		Clathrin_propel	198..234	CDD:460192	25/35 (71%)
		Clathrin_propel	256..288	CDD:460192	25/31 (81%)
		Clathrin_propel	296..330	CDD:460192	28/33 (85%)
		Clathrin-link	331..354	CDD:462732	19/22 (86%)
		Clathrin_H_link	356..421	CDD:463995	46/65 (71%)
		CLH	541..674	CDD:128594	113/132 (86%)
		CLH	686..824	CDD:128594	122/137 (89%)
		CLH	833..968	CDD:128594	114/134 (85%)
		CLH	979..1118	CDD:128594	120/138 (87%)
		TPR repeat	1105..1131	CDD:276809	23/25 (92%)
		CLH	1128..1265	CDD:128594	98/136 (72%)
		CLH	1274..1416	CDD:128594	122/141 (87%)
		Clathrin	1427..1564	CDD:459884	101/136 (74%)