Protein Alignment Chc and cltcl1

DIOPT Version :10

• Sequence 1: NP_477042.1
• Gene: Chc / 32537
• FlyBaseID: FBgn0000319
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: XP_004910633.2
• Gene: cltcl1 / 100492311
• XenbaseID: XB-GENE-22064760
• Length: 1681
• Species: Xenopus tropicalis
• Alignment Length: 1667
• Identity: 1315/1667 - (78%)
• Similarity: 1493/1667 - (89%)
• Gaps: 5/1667 - (0%)

  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.||||||||:||.|:|||..:..|||||||||||||:||||.:.||||||||.:..:|.|||
 Frog     1 MAQILPIRFQEHMQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMAEPNSPLRRP 65

  Fly    66 ISADSAIMNPASKVIALK-AQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFH 129
            |||:|||||||||||||| |.|||||||||||||||||||:|:|:||||||:||:||||||:|:|
 Frog    66 ISAESAIMNPASKVIALKDAGKTLQIFNIEMKSKMKAHTMSEEVIFWKWISVNTVALVTETAVYH 130

  Fly   130 WSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAI 194
            |||||||.||||||||:||.||||||||.:..|:||||:||||..:||.||||||||:|||||.|
 Frog   131 WSMEGDSQPQKMFDRHASLAGCQIINYRTDEQQKWLLLIGISAQQNRVVGAMQLYSVDRKVSQPI 195

  Fly   195 EGHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQND 259
            |||||:||.|||:.|.:|:||||||||...||||||||||.|.||||||||||||||||||||.|
 Frog   196 EGHAAAFAEFKIERNSKPSTLFCFAVRGQAGGKLHIIEVGQPANGNQPFAKKAVDVFFPPEAQTD 260

  Fly   260 FPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQV 324
            ||||||:.:|:..|||||||||||:||:|:..|||||||||||||||||:|.:.||||||:||||
 Frog   261 FPVAMQIGSKHGVIYLITKYGYIHMYDLESGACIYMNRISADTIFVTAPYEPTSGIIGVNKKGQV 325

  Fly   325 LSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPK 389
            |||.|:||.|:.|..:|||||||.||||||:||.|||:||.||||.:|..|.|:|||||||.|||
 Frog   326 LSVCVEEENIVNYATSVLQNPDLGLRMAVRSNLPGAEELFARKFNTMFAQGNYSEAAKVAASAPK 390

  Fly   390 AILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLK 454
            .||||.:||::.|.|....|..: |||||||||||||:|||.||||||||||.||:|||.|||||
 Frog   391 GILRTAETIRKIQAVPAQPGQAS-PLLQYFGILLDQGQLNKLESLELCRPVLQQGRKQLLEKWLK 454

  Fly   455 EEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLL 519
            |:|||||||||||||..|.|||||:||||||||||||||||||||||||||||||.||||::|||
 Frog   455 EDKLECSEELGDLVKTVDPTLALSVYLRANVPNKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLL 519

  Fly   520 RSVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTR 584
            |||||.:|:||..||.|||.:|||||:||||||:|||:|::||||:|||||||:|||:||.||||
 Frog   520 RSVMRISPDQGLQFAQMLVQDEEPLANINQIVDVFMENSLIQQCTSFLLDALKNNRPSEGHLQTR 584

  Fly   585 LLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNA 649
            ||||||:.|||||||||||.|||||||||||||||||||||||||||||||||||||||||:|||
 Frog   585 LLEMNLIHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHLLNA 649

  Fly   650 EWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFY 714
            ||||:|||:||||||:|||:|||:||:|||||:.||:|:||||||..::|::|||.||||:||||
 Frog   650 EWLVNFFGSLSVEDSVECLRAMLSANIRQNLQLSVQVASKYHEQLGTQSLVELFESFKSYEGLFY 714

  Fly   715 FLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVC 779
            ||.|||||||||:||||||||||||.|||||||||||||||||||||||||||||||||||||||
 Frog   715 FLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVC 779

  Fly   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTD 844
            |||||||||||||||||||||||||||||||||:|.|||||||||||||:|||||:||.||||||
 Frog   780 DRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRIPAVVGGLLDVDCSEDVIKNLIMVVHGQFSTD 844

  Fly   845 ELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVVGRY 909
            |||.||||||||||||||||||:||||.|||||||||||||||||||||:|:||.||||.|||:|
 Frog   845 ELVAEVEKRNRLKLLLPWLESRIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSCVVGKY 909

  Fly   910 CEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQLIDQ 974
            ||||||||||||||||.||.|||.||||||||||||||||.|:||||||.||.|:||::||||||
 Frog   910 CEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVRRKDAELWANVLEENNPFRRQLIDQ 974

  Fly   975 VVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKADRT 1039
            ||||||||||||:::||||||||||:||||||||||||:||:||||:||||||||||||||||||
 Frog   975 VVQTALSETQDPEEVSVTVKAFMTAELPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRT 1039

  Fly  1040 RVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCN 1104
            |||:|||||:||||||||||||||||:|||||||:|||||||||||||:.:.||:||.|||||||
 Frog  1040 RVMEYINRLDNYDAPDIANIAISNQLFEEAFAIFRKFDVNTSAIQVLIEHIGNLDRAYEFAERCN 1104

  Fly  1105 EPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESY 1169
            |.||||||.:||||:.||||||||||||||||:|::||..||:..:|:|||::|||||||||||:
 Frog  1105 ESAVWSQLGRAQLQKDLVKEAIDSYIKADDPSSYMEVVQAASRNSNWEDLVKFLQMARKKARESF 1169

  Fly  1170 IESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVY 1234
            :|:|||:|.|:|.||::||||:||||:|.||::|:||:.:||||||||||||||||||||.|||:
 Frog  1170 VETELIFALAKTNRLSELEEFVSGPNNAHIQQVGDRCYEEGMYDAAKLLYNNVSNFARLASTLVH 1234

  Fly  1235 LKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDE 1299
            |.|:|.|||||||||||||||||||||||..|||||||||||||:||||||:||:|||:||||:|
 Frog  1235 LGEYQAAVDSARKANSTRTWKEVCFACVDGTEFRLAQMCGLHIVIHADELEELISYYQDRGYFEE 1299

  Fly  1300 LIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVF 1364
            ||||||:||||||||||||||||||||||||.|||||||||||||||||||||||.||||.||||
 Frog  1300 LIALLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWGELVF 1364

  Fly  1365 LYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAP 1429
            |||||||||||::.||.|||.||:||.||||:|||||:||||||::||:::||||:||:|:||:|
 Frog  1365 LYDKYEEYDNAIITMMNHPTSAWKEGQFKDIVTKVANVELYYKALQFYMEYKPLLINDLLIVLSP 1429

  Fly  1430 RMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNI 1494
            |:||||.|:||.|...||||||||||||:.|||::|||||.||.:||||||||.|||.:||||||
 Frog  1430 RLDHTRTVNYFFKVNQLPLVKPYLRSVQNHNNKSVNEALNNLLTEEEDYQGLRASIDAYDNFDNI 1494

  Fly  1495 ALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFL 1559
            :|||:||||||.||||||||||||||||||||||||||:||||||.|||||...::||.||.|||
 Frog  1495 SLAQRLEKHELIEFRRIAAYLYKGNNRWKQSVELCKKDRLYKDAMLYAAESKDTELAENLLQWFL 1559

  Fly  1560 ERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQREKE 1624
            |....:||||.|:.|||||..|::|||||:|.|:||||||.|||:|||.||||||...|:.|::.
 Frog  1560 EEGKQECFAATLFTCYDLLHADIVLELAWRHHIMDFAMPYFIQVMREYLTKVDKLHAAESLRKEA 1624

  Fly  1625 DDSTEHKNIIQMEPQLMITAGPAMGIPPQYAQNYPPGAATVT 1666
            :..||...|: ...|||:||||:..:|||  .|:|.|.|..|
 Frog  1625 EQVTEPTPIV-FGQQLMLTAGPSGVVPPQ--PNFPYGYAAPT 1663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_477042.1	Clathrin_propel	19..56	CDD:460192	27/36 (75%)
		Clathrin_propel	148..187	CDD:460192	27/38 (71%)
		Clathrin_propel	198..234	CDD:460192	25/35 (71%)
		Clathrin_propel	256..288	CDD:460192	23/31 (74%)
		Clathrin_propel	296..330	CDD:460192	27/33 (82%)
		Clathrin-link	331..354	CDD:462732	15/22 (68%)
		Clathrin_H_link	356..422	CDD:463995	40/65 (62%)
		CLH	542..672	CDD:128594	112/129 (87%)
		CLH	687..825	CDD:128594	123/137 (90%)
		CLH	834..969	CDD:128594	115/134 (86%)
		CLH	980..1118	CDD:128594	117/137 (85%)
		Clathrin	1129..1268	CDD:459884	101/138 (73%)
		CLH	1275..1417	CDD:128594	118/141 (84%)
		Clathrin	1429..1562	CDD:459884	103/132 (78%)
cltcl1	XP_004910633.2	Clathrin_propel	19..55	CDD:460192	26/35 (74%)
		Clathrin_propel	149..188	CDD:460192	27/38 (71%)
		Clathrin_propel	199..235	CDD:460192	25/35 (71%)
		Clathrin_propel	257..289	CDD:460192	23/31 (74%)
		Clathrin_propel	297..331	CDD:460192	27/33 (82%)
		Clathrin-link	332..355	CDD:462732	15/22 (68%)
		Clathrin_H_link	357..422	CDD:463995	40/65 (62%)
		CLH	542..675	CDD:128594	114/132 (86%)
		CLH	687..825	CDD:128594	123/137 (90%)
		CLH	834..969	CDD:128594	115/134 (86%)
		CLH	980..1120	CDD:128594	119/139 (86%)
		Clathrin	1129..1268	CDD:459884	101/138 (73%)
		CLH	1275..1417	CDD:128594	118/141 (84%)
		Clathrin	1424..1565	CDD:459884	106/140 (76%)