Protein Alignment Rhp and Rhpn2

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_082173.3
• Gene: Rhpn2 / 52428
• MGIID: 1289234
• Length: 686
• Species: Mus musculus
• Alignment Length: 681
• Identity: 260/681 - (38%)
• Similarity: 379/681 - (55%)
• Gaps: 102/681 - (14%)

  Fly    17 ENEDDEKLNELSFCFVRGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRD 81
            |.|.|:       .|.:|.:|.|.|.||||||:|..||::|.|.:|:|.|||||.|..:|:|:|:
Mouse    14 EKEGDD-------YFRKGCNPLAQTGRSKLQNQRAALNQQILKAVRMRTGAENLLKVATNQKVRE 71

  Fly    82 TVALELSFVNSNLQLLKEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEH 146
            .|.||||||||:||:|||:|..||.||.:||.......:|:||||||||||::|...|.||||||
Mouse    72 QVRLELSFVNSDLQMLKEELEGLNISVGVYQGTEEAFTIPLIPLGLKETKEVDFSIVFKDFILEH 136

  Fly   147 YSEEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDS 211
            |||:..:|.|.|||:.|.|||.:|||||..||.||..|:..|.:||.|||||.|::|:.|.||||
Mouse   137 YSEDSYLYEDDIADLMDLRQACRTPSRDEAGVELLMSYFIQLGFVESRFFPPTRHMGLLFTWYDS 201

  Fly   212 LTGVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNA 276
            .||||..|:|:..|||..|||:|.:|||||.|.:|.|:.||:.|||:|.|||||..::.:|||:.
Mouse   202 FTGVPVSQQTLLLEKASVLFNIGALYTQIGTRCNRQTQAGLESAVDAFQRAAGVLNYLKETFTHT 266

  Fly   277 PSMDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQ 341
            ||.|:.|.:|.|||.:||:||:|.:|||:.|  ..:.::......:|.|||:::..|.::|..:.
Mouse   267 PSYDMSPAMLSVLVKMMLAQAQESVFEKVCL--PGIQNEFFVLVKVAQEAAKVAEAYRQLHAAMS 329

  Fly   342 ANDTHTYLPECWAGLVPVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERIT 406
            .......:|..||.:..|||..|.|.||:: |.::....:||.. :.:.:||..:  ||..:|:
Mouse   330 QEPVKENIPYSWASVAYVKAYHYGALAHYF-AATLLIDHQLKPG-ADEDHQEKCL--SQLYDRM- 389

  Fly   407 TADYGASDEASTSIAN-KLA---------HLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVH 461
                   .|..|.:|. |.|         ||..|:...||:.|...:|:.|::...|.:|:...|
Mouse   390 -------PEGMTPLATLKNAGQRVLLGKGHLHRAIGFHEESLREANLCKKLRDIQVLRDVLSAAH 447

  Fly   462 SKSQEELEKFRLQASAKNIEDGDLL------------ERSVEASSKFTLSLTGPDFTSHKVKDPF 514
            .::|.:..:.|        ||.|||            ||.|:        :|.|||:...|.|.|
Mouse   448 QRTQLKHTQHR--------EDDDLLNLIDAPDVLPKTEREVK--------ITFPDFSKVTVTDFF 496

  Fly   515 KRLGPIAIFSARRHWTAPRCVRLQKGSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFG 579
            ::|||:::|||.:.|:.||        .::.:|...|                          .|
Mouse   497 QKLGPLSVFSASKRWSPPR--------GIHFTVEEGD--------------------------LG 527

  Fly   580 FHVRGDAPVIIAHVEINSLADLGGIKEGDFIVEIAGVDVKWYSHQQVVQLIQSC-GSTLELRVIT 643
            |.:||:.||.:..::.:..|.|.|.||||:||.|.|||.||.:..:|::|::|. |..:|::|::
Mouse   528 FTLRGNTPVQVHFLDPHCSASLAGAKEGDYIVSIQGVDCKWLTVSEVMKLLKSFGGEEVEMKVVS 592

  Fly   644 PMDRNYLKPLSSKGSLSTLSAASSSGISSGF 674
            .:|        |..|:....|..|.|:...:
Mouse   593 LLD--------STSSMHNKCATYSVGMQKTY 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	47/83 (57%)
		BRO1_Rhophilin	122..514	CDD:185767	163/413 (39%)
		PDZ_canonical	578..642	CDD:483948	26/64 (41%)
Rhpn2	NP_082173.3	HR1_Rhophilin-2	27..108	CDD:212024	46/80 (58%)
		Interaction with Rho. /evidence=ECO:0000250	46..66		10/19 (53%)
		BRO1_Rhophilin_2	112..496	CDD:185772	163/413 (39%)
		PDZ_rhophilin-like	514..591	CDD:467196	30/110 (27%)