Protein Alignment Rhp and PTPN23

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_056281.1
• Gene: PTPN23 / 25930
• HGNCID: 14406
• Length: 1636
• Species: Homo sapiens
• Alignment Length: 758
• Identity: 167/758 - (22%)
• Similarity: 284/758 - (37%)
• Gaps: 204/758 - (26%)

  Fly   120 MPMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRY 184
            ||||.|.|||..:.:|......|:|::|.|.|..|.:.:..:...||.:....||..|.::|.:|
Human     7 MPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPRDFEGCSVLRKY 71

  Fly   185 YNTLYYVERRF-FPPDRNLGVYFEWYDSLTGVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTT 248
            ...|:|::.|. ....:...|...|.:..:|.......|.:|:||.|:|||.:::.:||...|.:
Human    72 LGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYNLGALHSMLGAMDKRVS 136

  Fly   249 ERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMS 313
            |.|:.::...|..|||.|.::.:.|..|.|:|:..|:|.:.|:|||.||:|||.||      :|.
Human   137 EEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNLMLGQAQECLLEK------SML 195

  Fly   314 HDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYL---PECWAGLVPVKAELYKAFAHFYKARS 375
            .:.::|. :|..:||:...|.|..:.::..||.:.|   .:.|..||.:|...:.|.||.:..:.
Human   196 DNRKSFL-VARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQ 259

  Fly   376 ID--------------ATDELKASKSSQKNQESFIGNSQEVERITTADYGASDEASTSIANKLAH 426
            .:              |.|:|..:....|.|...:   |:..|.|....|....::....:.:.|
Human   260 AEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTV---QDALRFTMDVIGGKYNSAKKDNDFIYH 321

  Fly   427 LKEALASIEEAQRLQ------------------------RMCRFLKNKAS----------LTEVM 457
              ||:.:::..|.::                        ::.....::||          |.|:|
Human   322 --EAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMM 384

  Fly   458 KEVHSKSQEELEKF--RLQASAKNIEDGD--------LLER------------------------ 488
            .::..|: |.|::|  .:|...:.:::.|        |:|:
Human   385 AKIEDKN-EVLDQFMDSMQLDPETVDNLDAYSHIPPQLMEKCAALSVRPDTVRNLVQSMQVLSGV 448

  Fly   489 --SVEASSKFTLSLTGPD-FTSHKVKDPFKRLGPIAIFS------ARRHWT-------------- 530
              .||||.|....|...| ....|.::...:.|.|:|.|      .||.|.
Human   449 FTDVEASLKDIRDLLEEDELLEQKFQEAVGQAGAISITSKAELAEVRREWAKYMEVHEKASFTNS 513

  Fly   531 -APRCVRLQKGSSLYHSVP-------------SNDNKCPLDN----------------------- 558
             ..|.:.|..|:....|.|             |.::|..|.|
Human   514 ELHRAMNLHVGNLRLLSGPLDQVRAALPTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLR 578

  Fly   559 -----DD------DEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINSLAD---LGGIKEGDF 609
                 ||      ..:|.....|::|:.:.:        ..:..::|.|..|.   |..:.|.:
Human   579 ELIQKDDITASLVTTDHSEMKKLFEEQLKKY--------DQLKVYLEQNLAAQDRVLCALTEAN- 634

  Fly   610 IVEIAGV-------DVKWYSHQQVVQLIQSCGSTLELRVITPMDRNYLKPLSSK------GSLST 661
             |:.|.|       |.||.|..|.  |:.|..:..:|...:...|::...|.||      .:.||
Human   635 -VQYAAVRRVLSDLDQKWNSTLQT--LVASYEAYEDLMKKSQEGRDFYADLESKVAALLERTQST 696

  Fly   662 LSAASSSGIS------SGFPSPTSIAAKPKLHLKTSSSSRPAG 698
            ..|..::...      ...|.|...|.||.|..:..|.:..||
Human   697 CQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAG 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	112/480 (23%)
		PDZ_canonical	578..642	CDD:483948	16/73 (22%)
PTPN23	NP_056281.1	BRO1_HD-PTP_like	2..357	CDD:185762	93/361 (26%)
		TPR 1	250..283		6/32 (19%)
		V_HD-PTP_like	362..700	CDD:185747	64/350 (18%)
		TPR 2	374..407		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..812		9/39 (23%)
		PHA03247	<727..1083	CDD:223021	4/13 (31%)
		His	770..1130
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	888..1151
		6 X 2 AA approximate tandem repeats of P-Q	953..964
		PTP-N23	1243..1447	CDD:350387
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1513..1636