Protein Alignment Rhp and Rhpn1

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_001398180.1
• Gene: Rhpn1 / 14787
• MGIID: 1098783
• Length: 662
• Species: Mus musculus
• Alignment Length: 673
• Identity: 249/673 - (36%)
• Similarity: 365/673 - (54%)
• Gaps: 68/673 - (10%)

  Fly    19 EDDEKLNELSFCFVRGSDPRAATCRSKLQNRRCKLNKEINKELRLRAGAENLYKATSNRKLRDTV 83
            :||..:.:....||:...       .:||:.|.:|:::|:||||:|.||||||:||||..:|:||
Mouse    20 QDDGSIRKGYGSFVQNQP-------GQLQSHRARLHQQISKELRMRTGAENLYRATSNTWVRETV 77

  Fly    84 ALELSFVNSNLQLLKEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFILEHYS 148
            |||||:||||||||||:||||::||::.|.|.....:||||||||||||:::..|..:.|.||:.
Mouse    78 ALELSYVNSNLQLLKEELAELSTSVDVDQPEGEGITIPMIPLGLKETKELDWATPLKELISEHFG 142

  Fly   149 EEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEWYDSLT 213
            |:.:.:...|.::.|.|||::|||||..|:.||..||:.|.:::.|||.|.|:.|:.|.||||||
Mouse   143 EDGTSFETEIQELEDLRQATRTPSRDEAGLDLLAAYYSQLCFLDARFFSPSRSPGLLFHWYDSLT 207

  Fly   214 GVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFRHIYDTFTNAPS 278
            |||:.||.:||||...|||:|.::||||||.|.:...|.:.|.::|.||||.||.:.:.|::|||
Mouse   208 GVPAQQRALAFEKGSVLFNIGALHTQIGARQDCSCTEGTNHAAEAFQRAAGAFRLLRENFSHAPS 272

  Fly   279 MDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHEYNEMHKNIQAN 343
            .|:....|.:|..||::||:||:|:.|.|...|....|.....||.||||::.||..:|:.:...
Mouse   273 PDMSAASLSMLEQLMIAQAQECIFKGLLLPASATPDICPDQLQLAQEAAQVATEYGLVHRAMAQP 337

  Fly   344 DTHTYLPECWAGLVPVKAELYKAFAHFYKARSIDATDELKASKSSQKNQESFIGNSQEVERITTA 408
            ....|||..|..|..||||.:.|.||::.|.::  .:...|:|.....||.....|...|.:
Mouse   338 PVRDYLPASWTNLAHVKAEHFCALAHYHAAMAL--CESHPAAKGELARQEHVFQPSTPHEPL--- 397

  Fly   409 DYGASDEASTSIANKL--AHLKEALASIEEAQRLQRMCRFLKNKASLTEVMKEVHSKSQEELEKF 471
              |.:.........||  ||||.|:...|||.||..:||.|: |..|.:|:  |....:..|.|:
Mouse   398 --GPTLPQHPEDRRKLAKAHLKRAILGQEEALRLHTLCRVLR-KVDLLQVV--VTQALRRSLAKY 457

  Fly   472 RLQASAKNIEDGDLLERS----VEASSKFTLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWTAP 532
                |....|| |..|.:    ::..:..|..:..|..:..||.|.|.||||:::||.:..|...
Mouse   458 ----SQLERED-DFFEATEAPDIQPKTHQTPEVRMPSLSQVKVTDFFHRLGPLSVFSTKNRWQLV 517

  Fly   533 RCVRLQKGSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINS 597
            ..|.:.:|..                                  :|||.:|||:||:||.|....
Mouse   518 GPVHMTRGEG----------------------------------SFGFTLRGDSPVLIAAVVPGG 548

  Fly   598 LADLGGIKEGDFIVEIAGVDVKWYSHQQVVQLIQSCGST-LELRVITPMDRNYLKPLSSKGSLST 661
            .|:..|:||||:||.:.|...||:.|.:||..::|.|.. :.|:|:     :.|.....:|:...
Mouse   549 QAESAGLKEGDYIVSVNGQPCKWWKHLEVVTQLRSMGEEGVSLQVV-----SLLPSPEPRGTGPR 608

  Fly   662 LSAASSSGISSGFPSPTSIAAKP 684
            .:|...:....||.:|.....:|
Mouse   609 RAALLWNQRECGFETPMPTRTRP 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	46/83 (55%)
		BRO1_Rhophilin	122..514	CDD:185767	152/397 (38%)
		PDZ_canonical	578..642	CDD:483948	28/64 (44%)
Rhpn1	NP_001398180.1	HR1_Rhophilin-1	28..112	CDD:212023	48/90 (53%)
		BRO1_Rhophilin_1	116..499	CDD:185771	152/397 (38%)
		PDZ_rhophilin-like	519..594	CDD:467196	30/108 (28%)