Protein Alignment Rhp and Ptpn23

DIOPT Version :10

• Sequence 1: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_001074512.1
• Gene: Ptpn23 / 104831
• MGIID: 2144837
• Length: 1692
• Species: Mus musculus
• Alignment Length: 771
• Identity: 168/771 - (21%)
• Similarity: 277/771 - (35%)
• Gaps: 227/771 - (29%)

  Fly   120 MPMIPLGLKETKEINFMEPFSDFILEHYSEEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRY 184
            ||||.|.|||..:.:|......|:|::|.|.|..|.:.:..:...||.:...:||..|.::|.:|
Mouse     7 MPMIWLDLKEAGDFHFQSAVKKFVLKNYGENPEAYNEELKKLELLRQNAIRVARDFEGCSVLRKY 71

  Fly   185 YNTLYYVERRF-FPPDRNLGVYFEWYDSLTGVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTT 248
            ...|:|::.|. ....:...|...|.:..:|.......|.:|:||.|:|||.:::.:||...|.:
Mouse    72 LGQLHYLQSRVPMGSGQEAAVAVTWTEIFSGKSVSHEDIKYEQACILYNLGALHSMLGAMDKRVS 136

  Fly   249 ERGLDLAVDSFLRAAGVFRHIYDTFTNAPSMDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMS 313
            |.|:.::...|..|||.|.::.:.|..|.|:|:..|:|.:.|:|||.||:|||.||      :|.
Mouse   137 EEGMKVSCTHFQCAAGAFAYLREHFPQAFSVDMSRQILTLNVNLMLGQAQECLLEK------SML 195

  Fly   314 HDCQAFRDLAGEAAQISHEYNEMHKNIQANDTHTYL---PECWAGLVPVKAELYKAFAHFYKARS 375
            .:.::|. :|..:||:...|.|..:.::..||.:.|   .:.|..||.:|...:.|.||.:..:.
Mouse   196 DNRKSFL-VARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKLVQMKIYYFAAVAHLHMGKQ 259

  Fly   376 ID---------------------------------------ATDELKASKSSQKNQESFIGNSQE 401
            .:                                       |.|.:....:|.|....||.: :.
Mouse   260 AEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRFAMDVIGGKYNSAKKDNDFIYH-EA 323

  Fly   402 VERITTAD--YGA----------SDEAST--SIANKL----AHLKEALASIEEAQRLQRMCRFLK 448
            |..:.|..  .||          :|.|.|  .|..||    ||...:|.|.|:|:.|:.|...::
Mouse   324 VPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKLVPMAAHEASSLYSEEKAKLLREMLAKIE 388

  Fly   449 NKASLTEVMKEVHSKSQ------EELEKFR----------------------------------- 472
            :|   .||:.:.....|      :.|:.:.
Mouse   389 DK---NEVLDQFMDSMQLDPETVDNLDAYNHIPPQLMEKCAALSVRPDTVKNLVQSMQVLSGVFT 450

  Fly   473 -LQASAKNIEDGDLLERSVEASSKF--TLSLTGPDFTSHKVKDPFKRLGPIAIFSARRHWT---- 530
             ::||.|:|.  ||||.......|.  ||...|        ..|...:....:...||.|.
Mouse   451 DVEASLKDIR--DLLEEDELQEQKLQETLGQAG--------AGPGPSVAKAELAEVRREWAKYME 505

  Fly   531 -----------APRCVRLQKGSSLYHSVP-------------SNDNKCPLDN------------- 558
                       ..|.:.|..|:....|.|             :.::|..|.|
Mouse   506 VHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAALPTPALTPEDKAVLQNLKRILAKVQEMRD 570

  Fly   559 ---------------DD------DEEHDGGYNLYKEEFENFGFHVRGDAPVIIAHVEINSLAD-- 600
                           ||      ..:|.....|::|:.:.:        ..:..::|.|..|.
Mouse   571 QRVSLEQQLRELIQKDDITASLVTTDHSEMKKLFEEQLKKY--------DQLKVYLEQNLAAQDN 627

  Fly   601 -LGGIKEGDFIVEIAGV-------DVKWYSHQQVVQLIQSCGSTLELRVITPMDRNYLKPLSSKG 657
             |..:.|.:  |:.|.|       |.||.|..|.  |:.|..:..:|...:...:::...|.||
Mouse   628 VLRALTEAN--VQYAAVRRVLSELDQKWNSTLQT--LVASYEAYEDLMKKSQEGKDFYADLESK- 687

  Fly   658 SLSTLSAASSS---------------GISSGFPSPTSIAAKPKLHLKTSSSSRPAG 698
             ::||...:.|               .:....|.|...|.||.|..:....:..||
Mouse   688 -VATLLERAQSICRAQEAARQQLLDRELKKKAPPPRPTAPKPLLSRREEGEAVEAG 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023
		BRO1_Rhophilin	122..514	CDD:185767	119/496 (24%)
		PDZ_canonical	578..642	CDD:483948	16/73 (22%)
Ptpn23	NP_001074512.1	BRO1_HD-PTP_like	2..357	CDD:185762	93/357 (26%)
		TPR 1	250..283		3/32 (9%)
		V_HD-PTP_like	362..702	CDD:185747	64/366 (17%)
		TPR 2	374..407		8/35 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..788		8/32 (25%)
		PHA03247	<733..1139	CDD:223021	2/10 (20%)
		His	773..1186
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	884..923
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	944..1199
		21 X 2 AA approximate tandem repeats of P-Q	977..1018
		PTP-N23	1299..1503	CDD:350387
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1574..1638