Protein Alignment HUWE1 and UPL7

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_190877.1
• Gene: UPL7 / 824475
• AraportID: AT3G53090
• Length: 1142
• Species: Arabidopsis thaliana
• Alignment Length: 995
• Identity: 232/995 - (23%)
• Similarity: 383/995 - (38%)
• Gaps: 258/995 - (25%)

  Fly  4346 KLIVNLT-QCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNE---------------IRMYNIH 4394
            |:|.|.. :.::.:..|.||::.:...|....||:.|:.|...               :|.:::.
plant   198 KIITNENFEDAETAKKIIIQFIGSCKSGYYSAVRRYIKTLTKHTDERLVITTSAVTLALRPFHVK 262

  Fly  4395 QGGAGTTSQAASTSGAAAATASYVPTVSG-ASLLPNLAV----HEGIMQDRFTAEHV-------- 4446
            | .|........|:.|.....|.:.|:.. ...||:..:    |:.|:...|   |.
plant   263 Q-PAFVDDNQPDTNLAVEEYVSLILTIPRLVCYLPSALIRALKHKSILMPSF---HTILLLKDKI 323

  Fly  4447 --IISAPKNA-KPTCELQLPSMKKLMSN-----------------SSAQPYFLRTLKIFMQVRDM 4491
              |||..:|: |.:|.:::||:..::.|                 |:.:.:::..:.:.:.:
plant   324 LNIISEMENSEKQSCTMEIPSVGWVIGNIISLATVSETDFMDPQESNPEMFYVLYVHVIVTL--- 385

  Fly  4492 YEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPME--------T 4548
              |:|.||....|..     .|..:|||       .:|::...|::..||....:.        .
plant   386 --AENLLSQVESVGI-----QDIHLDIE-------ATSNETEKGNSVKISFVEMLRPVCQQWHLA 436

  Fly  4549 NQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLS------------QILC--------L 4593
            ..:|..|          :....:.:...:::||....||.            :|.|        |
plant   437 KLLAASG----------KEIRVIADKDASTSSKKGSETLGLLDIARLYSCMLRIFCVMNPVLGPL 491

  Fly  4594 DVLWNTLSEC---LVALEESKDEFAVLVLQP----TVEAFFLIHASHRGA--------------- 4636
            .|| |.||.|   :|:|..|.:.    ||.|    |.:     .|||..|
plant   492 PVL-NMLSFCPGYIVSLWNSLES----VLLPENGCTAD-----DASHGSAKTSWNTRSPSEKKLK 546

  Fly  4637 --------------SKKSGRSFMPNAAGFGLRAAAGAGAIGG-----------LGAAAPSAQEYS 4676
                          :|.||:|..|...........|:|.:..           .|.....::|.|
plant   547 HLKNDSVNKWVNVLNKFSGKSPGPREHVECTSDQPGSGQVNESTNDVWDVETLRGGPVGISKEVS 611

  Fly  4677 --------------PFMDDVSSANTPSSASFDDEPRMQDASTNTPLV-------TNPSTSTAMSA 4720
                          ..:||:....  ....|..|.:.:.||....||       |.|.:...|.:
plant   612 CLLHLFCATYAHLLVVLDDIQFYE--KQVPFMLEKQQRIASMLNTLVYYGLLRGTGPESRQLMDS 674

  Fly  4721 -----HEAQLRQDRQKF----------------LQFAEKHRTVL--NQILRQSPTHLSDGPFAVL 4762
                 |....|..|..|                :.||.:...||  :.:|    |..|.|....:
plant   675 AIRCLHLLYERDCRHPFCASALWLSPGRTSRPPIAFAARTHEVLPTSDVL----TTPSMGSVITI 735

  Fly  4763 VDHTRILDFDVKRKYFQTELERLDEGIRREEHTVS----------VRRVTVFEDSFRVLYRLGPE 4817
            ..|  :..|:.:...|:..:.: |:..|:....|.          |||..|.||.|:.|..:| .
plant   736 TPH--VFPFEERVHVFREFISK-DKASRKMAGEVDAPGARSIEIVVRRGHVVEDGFQQLNSIG-S 796

  Fly  4818 EWKNRFYIVFEDEE-----GQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHAN 4877
            ..|:..::.|.:|.     |.|.|||.:|:...|::..|...|.||..:|......:.:||:...
plant   797 RLKSSIHVSFVNESGLPEAGLDYGGLSKEFLTDITKAAFATEYGLFSQTPTSDRLLVPSPSARHL 861

  Fly  4878 PNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYL--MKN 4940
            .|.:...:|:||::.||:::..||:..|:..|.:.:||:.....::...|.|.|:.|.|:  ...
plant   862 ENGIQMIEFLGRIVGKALYEGILLDYSFSHVFIQKLLGRYSFIDELSGLDPELYRNLMYVKHYDG 926

  Fly  4941 DISTLGYELTFSTEVQEF-GVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFL 5004
            |:..|..:.|.:   :|| |...|.:|||.|:||:||.|||.:|:..:...|::..|....:||.
plant   927 DLKELCLDFTVT---EEFCGKMSIIELKPGGKDTSVTNENKMQYIHAMADYKLNRQIVPFSNAFY 988

  Fly  5005 EGFYDIIPKHLISIFNEQEL-ELLISGLPDIDIEDLKANTEY-HKYTSKSAQIQWFWRALRSFDQ 5067
            .|..|:|....:.:||..|. :||..|..|||::||:.||:| ..|:..|..|:.||..::.|:.
plant   989 RGLTDLISPAWLKLFNAHEFNQLLSGGNHDIDVDDLRRNTKYTGGYSDSSRTIKIFWEVMKGFEP 1053

  Fly  5068 ADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHR-----------DDRSTDRLPCAHTCFNQ 5121
            ::|...|:|||..|:.||.||..|:     ..|.||:           ..:..:|||.|.||:|.
plant  1054 SERCLLLKFVTSCSRAPLLGFKYLQ-----PTFIIHKVSCDTSLWAAIGGQDVERLPSASTCYNT 1113

  Fly  5122 LDLPMYKSYDKLRSCLLKAI 5141
            |.||.||....:|..||.||
plant  1114 LKLPTYKRASTMREKLLYAI 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	121/377 (32%)
UPL7	NP_190877.1	IQCD	33..>62	CDD:467745
		HECTc	774..1140	CDD:238033	120/369 (33%)