Protein Alignment HUWE1 and UPL6

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_188346.2
• Gene: UPL6 / 820979
• AraportID: AT3G17205
• Length: 1029
• Species: Arabidopsis thaliana
• Alignment Length: 808
• Identity: 204/808 - (25%)
• Similarity: 336/808 - (41%)
• Gaps: 137/808 - (16%)

  Fly  4436 IMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLST 4500
            ::..|::...:|::.|...|     ..|::|.:.:|.|...:::..:...:|.............
plant   261 VVDPRWSFSSMILTIPLIWK-----LFPNLKVVFANPSLSQHYIHQMASCIQKDTCVLPMETSPE 320

  Fly  4501 GGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQ-IAQDGDDDEED--- 4561
            ..|.||..|:..|....:......|...:.|:|..:...:...||::::: .::.|..||:|
plant   321 FPGYACLLGNTLDTANVVLSQPECSLDMAIDIALVATFFLETLPPVKSSEGESRQGSSDEDDMLI 385

  Fly  4562 DDEARSFPG-VGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEA 4625
            ||    .|| |.|.|:.....:...:...:...:||:..:|..:.:.:|.|:..|:......:.|
plant   386 DD----VPGLVLNKALEQQITNAIDSRFLLQLTNVLFRQVSLGMQSYDEDKEALAIGTASSFLYA 446

  Fly  4626 FF-----------------LI----------HASHRGASKKSGRSFMP-NAAGFGLRAAAGAGAI 4662
            .|                 |:          |.:.:.:|.....:::| :|.|:.|.........
plant   447 AFNTLPLERIMTILAYRTELVAVLWNYMKRCHENQKWSSMPKLLAYLPGDAPGWLLPLVVFCPVY 511

  Fly  4663 GGLGAAAPSAQEYSP------------------------FMDDVSSANTPSSASFD---DEP--- 4697
            ..:.....:.:.|..                        :::.::..||..|.|.|   ..|
plant   512 KHMLMIVDNEEFYEREKPLSLQDIRLLIIILKQALWQLLWVNPLTQPNTGKSVSNDLSKKNPIEL 576

  Fly  4698 --------------RMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILR 4748
                          ::||.: |....|:.|...|.|.:|        .|:..|....|..|.||.
plant   577 IQNRMGIVVSELLSQLQDWN-NRKQFTSSSDFQADSVNE--------YFISQAIMEGTRANYILM 632

  Fly  4749 QSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEH---------TVSVRRVTVF 4804
            |:|.               ::.|..:.|.|.|:|     ...|:.|         ...:||..:.
plant   633 QAPF---------------LIPFTSRVKIFTTQL-----ATARQSHGSQGIFARNRFRIRRDHIL 677

  Fly  4805 EDSFRVLYRLGPEEWKNRFYIVF-----EDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGD 4864
            ||::..:..|..::.::...:.|     .:|.|.|.||:.:::...|:|..|:..|.|| ....|
plant   678 EDAYNQMSALSEDDLRSSIRVTFVNELGVEEAGIDGGGIFKDFMEKITRAAFDVQYGLF-KETAD 741

  Fly  4865 RVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYE 4929
            .:.|....|...:..||.:|.|:|.::|||:.:..|::..|...|...:..|.....|:.|.|.|
plant   742 HMLYPNPGSGMIHEQHLQFFHFLGSLLAKAMFEGILVDIPFATFFLSKLKQKYNYLNDLPSLDPE 806

  Fly  4930 FYKGLDYL--MKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKM 4992
            .|:.|.:|  .|.|||.|  ||.|.....|:|.....:|.|.|:|..||.||...::.||...::
plant   807 LYRHLIFLKRYKGDISDL--ELYFVILNNEYGERTEEELLPGGQDMRVTNENVITFIHLVSNHRL 869

  Fly  4993 SGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPD-IDIEDLKANTEY-HKYTSKSAQI 5055
            :..||||...||.||..:|||..|.:|||.||::||||..| :||:||:.||.| ..|.:....|
plant   870 NFQIRQQSSHFLRGFQQLIPKEWIDMFNEHELQVLISGSVDSLDIDDLRNNTNYAGGYHAGHYVI 934

  Fly  5056 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFN 5120
            ..||..::||...::.|||:||||.|:.||.||..||....||:......:.|.||||.:.||.|
plant   935 DMFWEVMKSFSTENQKKFLKFVTGCSRGPLLGFKYLEPAFCIQRAAGSASNESVDRLPTSATCMN 999

  Fly  5121 QLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            .|.||.|:|.:.|.:.|:.|| ....||
plant  1000 LLKLPPYQSKELLETKLMYAI-SAEAGF 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	129/362 (36%)
UPL6	NP_188346.2	HECTc	667..1027	CDD:238033	129/364 (35%)