Protein Alignment HUWE1 and Herc4

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_084390.1
• Gene: Herc4 / 67345
• MGIID: 1914595
• Length: 1057
• Species: Mus musculus
• Alignment Length: 453
• Identity: 117/453 - (25%)
• Similarity: 214/453 - (47%)
• Gaps: 42/453 - (9%)

  Fly  4721 HEAQ-LRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTEL-- 4782
            ||.| |...|..::.:.::....::  :....|.|:|.|..:.. :..:.|...|....||:.
Mouse   619 HEVQELIDIRNDYINWVQQQAYGVD--VSHGVTELADIPVTICT-YPFVFDAQAKTTLLQTDAVL 680

  Fly  4783 ---ERLDEGIRREEHT--------------VSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDE 4830
               ..:|:..|:...:              :.|||..:..|:..||.:....::|....::|..|
Mouse   681 QMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVGE 745

  Fly  4831 EGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAV 4895
            :..||||:.:|::::|.||:.:|.|.:|......|:.:..:.:...:    ..|..:|.:...|:
Mouse   746 DAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDS----DLFHLIGVICGLAI 806

  Fly  4896 HDNKLLECYFTRSFYKHILGKQVKHTD----MESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQ 4956
            ::..:::.:|..:.||.:|.::....|    |.:......:.||| .::||... :.|.|:..|:
Mouse   807 YNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDY-PEDDIEET-FCLNFTITVE 869

  Fly  4957 EFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNE 5021
            .||.|::::|..||.||||..:|:.|:|........:.|:....|||..||:.:....::.:|..
Mouse   870 NFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQP 934

  Fly  5022 QELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPL 5085
            .||:.::.|..:.|.::|:.||||. :|.:....|:.||..........:.:||.|:||:.::|:
Mouse   935 NELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI 999

  Fly  5086 QGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            .|..||       |..|.........||.:|||||.||||.|...:.||..|::|| :.:|||
Mouse  1000 LGMKSL-------KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAI-DHNEGF 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	102/358 (28%)
Herc4	NP_084390.1	RCC1 1	1..51
		ATS1	3..338	CDD:444065
		RCC1 2	52..101
		RCC1 3	102..154
		RCC1 4	156..207
		RCC1 5	208..259
		RCC1 6	261..311
		RCC1 7	313..366
		HECTc	709..1055	CDD:238033	102/360 (28%)