Protein Alignment HUWE1 and nedd4l

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_021324693.1
• Gene: nedd4l / 559634
• ZFINID: ZDB-GENE-051118-2
• Length: 1274
• Species: Danio rerio
• Alignment Length: 710
• Identity: 233/710 - (32%)
• Similarity: 342/710 - (48%)
• Gaps: 148/710 - (20%)

  Fly  4529 SSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKS-TKPTLSQILC 4592
            ||.|..|.:....||.|.:::|..:         ..|::..||.:....|||.: |.|.|..
Zfish   619 SSSMTDGVSDQAQPPTPTQSSQTRR---------TRAQTVTGVEDTMSPSASYALTTPGLPP--- 671

  Fly  4593 LDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAA 4657
                         ..||.||        |....:::   :|...|....|..:......|  |:.
Zfish   672 -------------GWEERKD--------PKGRTYYV---NHNNRSTTWTRPILQQHTEDG--AST 710

  Fly  4658 GAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFD-DEPRMQ----------------DASTN 4705
            ...|:||..||.|             .|:|||::|.. .||:::                :.:.|
Zfish   711 SVAAVGGATAATP-------------PASTPSTSSGHLSEPQVRRPRSLSSPTVTLSSPLEGANN 762

  Fly  4706 TPL-------VTNPST------STAMSAHEA---------QLR---QDRQKFLQFAEKHRTVLNQ 4745
            .|:       .:||.:      |:..:.|:|         ::|   ..|..|:....:..|..:.
Zfish   763 VPIRRAVKDTFSNPQSPQPSPYSSPKTQHKANQSFLPPGWEMRIAPNGRPFFIDHNSRTTTWEDP 827

  Fly  4746 ILRQSPTHLSD---------GPF-------------AVLVDHTR--------------------- 4767
            .|:. |.|:..         ||.             ...:||..
Zfish   828 RLKY-PVHMRTKASLDPGDLGPLPPGWEERVHADGRTFYIDHNNKKTQWEDPRLQSPAITGPAVP 891

  Fly  4768 -ILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRL-GPEEWKNRFYIVFEDE 4830
             ..:|..|..||:.:|::..:...|.|  :.:.|..:||:|:|.:..| .|:..|.|.:|.||.|
Zfish   892 YSREFKQKYDYFRKKLKKPADIPNRFE--MKLHRNNIFEESYRRIMSLKRPDSLKARLWIEFESE 954

  Fly  4831 EGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSH-ANPNHLSYFKFVGRVIAKA 4894
            :|.|.||:.|||:.::|:|:|||.|.||..|..|..|..|||:|. .|.:|||||||:|||...|
Zfish   955 KGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMA 1019

  Fly  4895 VHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFG 4959
            |:..|||:.:|.|.|||.:||||:...||||.|.|:|..|.::::||.:.|  :|.|..:...||
Zfish  1020 VYHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL--DLRFCIDEDNFG 1082

  Fly  4960 VTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQEL 5024
            .|...||||:|.|..||.:||.||:.||.|.:....:::|::||||||.::||..||.||:|.||
Zfish  1083 QTYQVDLKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENEL 1147

  Fly  5025 ELLISGLPDIDIEDLKANTEY-HKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGF 5088
            |||:.||.|:|:.|.:.:|.| :.|......|||||:|:...|...|.:.||||||||:||:.||
Zfish  1148 ELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGF 1212

  Fly  5089 GSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            ..|.|.||.|.|.|.:.. :.|:||.||||||:||||||::::.||..||.|: |.::||
Zfish  1213 AELYGSNGPQLFTIEQWG-TPDKLPRAHTCFNRLDLPMYETFEDLREKLLMAV-ENAQGF 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	168/356 (47%)
nedd4l	XP_021324693.1	C2	<374..430	CDD:472691
		WW	473..499	CDD:459800
		WW	669..698	CDD:459800	8/55 (15%)
		WW	798..829	CDD:197736	4/30 (13%)
		WW	848..880	CDD:197736	3/31 (10%)
		HECTc	941..1270	CDD:214523	159/332 (48%)