DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and HERC6

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:XP_005263140.1 Gene:HERC6 / 55008 HGNCID:26072 Length:1034 Species:Homo sapiens


Alignment Length:943 Identity:198/943 - (20%)
Similarity:327/943 - (34%) Gaps:253/943 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  4371 LGLAEE---------VRQAIQMLLNEIRMYNIHQGGA--------GTT-SQAASTSGAAAATASY 4417
            |||.:|         ||.     |..|.:..:..|||        ||: ...::::|..|.:...
Human   172 LGLGKEFPSQASPQRVRS-----LEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRN 231

  Fly  4418 VPTVSGASL----LPNLAV--------HEGIMQDRFTAEHVIISAPKNA------KPTCELQLPS 4464
            ||..|...|    |.||.|        |..::    |.:..:.:...|.      .||.|.:.|.
Human   232 VPVQSNKPLSVGALKNLGVVYISCGDAHTAVL----TQDGKVFTFGDNRSGQLGYSPTPEKRGPQ 292

  Fly  4465 MKK----LMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDND------------- 4512
            :.:    |:|......|  .||....            :||..|:.|.|.:|             
Human   293 LVERIDGLVSQIDCGSY--HTLAYVH------------TTGQVVSFGHGPSDTSKPTHPEALTEN 343

  Fly  4513 ---------DDIIDIEGDGGASG----------GSSSDMAPGSA----STISPPPPMETNQIAQD 4554
                     :|.:|::.....:|          .:||..|||..    |.||.....:...:.:.
Human   344 FDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIAVKRR 408

  Fly  4555 GDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVL 4619
            ..:.|....|.|..  ..:.|..:||...|....:...:|          |.||.::|.|..|  
Human   409 STEHEMAKSEIRMI--FSSPACLTASFLKKRGTGETTSID----------VDLEMARDTFKKL-- 459

  Fly  4620 QPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYS-------- 4676
                             :||...|.|       :........:..|...:|..:..|        
Human   460 -----------------TKKEWISSM-------ITTCLEDDLLRALPCHSPHQEALSVFLLLPEC 500

  Fly  4677 PFMDDVSSAN-----TPSSASFDDEPR------------MQDASTNTPLVTNPSTSTAMSAHEAQ 4724
            |.|.|  |.|     .|.:.:..:..:            :|::|.|..:....:...:...|:.:
Human   501 PVMHD--SKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQLLHQTK 563

  Fly  4725 LRQD--RQKFL--QFAEKHR-------------------TVLN-------QILRQ---------S 4750
            ..||  ..|.|  ...|.|:                   .:||       |:.|.         |
Human   564 TEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPS 628

  Fly  4751 PTHLSDGPFAV-LVDHTRILDFD--------VKRKYF---QTELERLDEGIRREEHTVSVRRVTV 4803
            |...||.||.. .:...::|..|        .|:.|.   :|.|::.||........:.|||..:
Human   629 PVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRL 693

  Fly  4804 FEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCV-SPGDRVT 4867
            .:|:.|.|.:....::.....:.|.:|...::||:..|::..:..|:..|.|.:|.. ..|..:.
Human   694 VKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMW 758

  Fly  4868 YMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYK 4932
            :...|    .|....||.| |.:...::.:..:....|..:.||.:|.::....|::.......|
Human   759 FPAKP----KPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGK 818

  Fly  4933 GLDYLMKNDISTLGYEL--TFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGS 4995
            .|..::.:....:|..|  .||....:..|    ||.|||....|.:.||.:||........:.|
Human   819 SLQEVLDDAADDIGDALCIRFSIHWDQNDV----DLIPNGISIPVDQTNKRDYVSKYIDYIFNVS 879

  Fly  4996 IRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHK-YTSKSAQIQWFW 5059
            ::...:.|..|||.:..|.::..|..:||...|.|..|.|.:..:.|::|.: |......||.||
Human   880 VKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFW 944

  Fly  5060 RALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQI---------HRDDRSTDRLPCA 5115
            :|.......::.|||.|:||..::..:         ||||.:|         .||.      |.:
Human   945 KAFHKLTLDEKKKFLFFLTGRDRLHAR---------GIQKMEIVFRCPETFSERDH------PTS 994

  Fly  5116 HTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            .||.|.|.||.|.:.:::...|..||:. :.||
Human   995 ITCHNILSLPKYSTMERMEEALQVAINN-NRGF 1026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 91/366 (25%)
HERC6XP_005263140.1 ATS1 27..>325 CDD:444065 38/175 (22%)
HECTc 684..1026 CDD:238033 89/366 (24%)
Blue background indicates that the domain is not in the aligned region.

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