Protein Alignment HUWE1 and ube3a

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_012812141.1
• Gene: ube3a / 407881
• XenbaseID: XB-GENE-948557
• Length: 908
• Species: Xenopus tropicalis
• Alignment Length: 1049
• Identity: 237/1049 - (22%)
• Similarity: 389/1049 - (37%)
• Gaps: 290/1049 - (27%)

  Fly  4238 QRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLS 4302
            :|.||         |:|....|.|             .::||  |:...||.
 Frog    11 EREGA---------PEPEERRTNT-------------PRSSP--GHSPEGDR------------- 38

  Fly  4303 VALPVTPSKPRRKIYSKNFSQLQL-------VIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSA 4360
                 :|..|    ||:|....::       :||...||  .|||..|  :...| ..|:...:.
 Frog    39 -----SPGDP----YSENLENSRMKRAAAKHLIERYYHQ--LTEGCGN--ETCTN-EFCASCPTF 89

  Fly  4361 IFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYV------- 4418
            :.:....|||        :|:::.....::.:.|....||:|.....:..:|...|..
 Frog    90 LRMDNNAAAI--------KALELYKVNAKLCDPHPSKKGTSSSYLENNSKSAHNNSCTERKMNKK 146

  Fly  4419 ------PTVSGASLLPNLAVHEGIMQDRFTAEH-VIISAPKNAKPTCELQLPSMKKLMSNSSAQP 4476
                  ......:.|....|:|.:...|...:: .:|........:.|..:.|.:|...::..:
 Frog   147 DLHGPRDDFKDVTFLSEEKVYEILELCREKEDYSPLIRVIGRVFSSAEALVQSFRKAKHHTKEE- 210

  Fly  4477 YFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTIS 4541
              |::|:...:.:|..|.:...|:...              :|.|.|||....||.:.|.
 Frog   211 --LKSLQEKDEDKDEDEKEKAASSAAA--------------MEEDSGASSSRLSDNSQGD----- 254

  Fly  4542 PPPPMETNQIAQDGDDDEEDDDEA--RSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECL 4604
                   |.|.:.|.::...|.||  |.:     |.:.|..|.....|:
 Frog   255 -------NNIQKLGPEEVSLDIEAVRRVY-----HRLLSNEKIETAFLN---------------- 291

  Fly  4605 VALEESKDEFAVLVLQPTVEAFFLIHASHRGASK---------KSGRSFMPNAAGFGLRAAAGAG 4660
                      |::.|.|.||.....|..:.....         ::|....|......|.....|.
 Frog   292 ----------ALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENGNLHSPEYLEMALPLFCKAM 346

  Fly  4661 AIGGLGAAAP--------SAQE-------------YSPFMDDVSSAN------------------ 4686
            :...|.|.|.        ||::             |....::.:|.|
 Frog   347 SKLPLAAQAKLIRLWSKYSAEQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAATKCLKMV 411

  Fly  4687 -----------TPSSASFDDEPRMQDASTNT--------------PLVTNPSTSTAMSAHEAQLR 4726
                       |..:...|||| :.::|..|              |.|....|...:.:.:.
 Frog   412 YYSNVVGGEIETDHNEEEDDEP-VPESSELTLQELLGEERRNKKGPRVDPLETELGVKSIDC--- 472

  Fly  4727 QDRQKFLQFAEKHRTVLNQILRQSPTHL-----SDGPFAVL--------VDHTRILDFDVK-RKY 4777
              |:..:.|.|.....||.:|.....:.     ::..|:.:        |.....|.:|.: |.|
 Frog   473 --RKPLIPFEEFVNEPLNDVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMY 535

  Fly  4778 FQ---TELERLDEGIRREEH-TVSVRRVTVFEDSFRVLYRL------GPEEWKNRFYIVFEDEEG 4832
            .:   |.|..|.:|.:...: .:.|||..:.:|:   |.||      .|.:.|.:.|:.||.|:|
 Frog   536 SERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDA---LVRLEMIAMENPADLKKQLYVEFEGEQG 597

  Fly  4833 QDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHD 4897
            .|.||:.:|::.::..|||||...:|......:.:: .||||......   |..:|.|:..|:::
 Frog   598 VDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKHSW-FNPSSFETEGQ---FTLIGIVLGLAIYN 658

  Fly  4898 NKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYE--------LTFS-T 4953
            |.:|:.:|....|:.::||:....|:.......|:.|..|::       ||        :||. :
 Frog   659 NCILDVHFPMVVYRKLMGKKGTFRDLADSHPVLYQSLKELLE-------YEGNVEEDMMMTFQIS 716

  Fly  4954 EVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLIS- 5017
            :...||...:.|||.||....:|.||:.|:|.|.....::.|:.:|..||..||      |:::
 Frog   717 QTDLFGNPLMHDLKENGDKIPITNENRKEFVSLYTDYILNKSVEKQFKAFRRGF------HMVTN 775

  Fly  5018 ------IFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQ 5075
                  :|..:|:||||.|..::|.:.||..|||. .||..|..|:.||..:.||.:..:..|||
 Frog   776 ESPLKYLFRPEEIELLICGSRNLDFQALKDTTEYDGGYTRDSNIIKEFWEIVNSFTEEQKRLFLQ 840

  Fly  5076 FVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKA 5140
            |.|||.:.|:.|.|.|       |..|.::...|||||.:|||||.|.||.|.:.:||:..||||
 Frog   841 FTTGTDRAPVGGLGKL-------KMIIAKNGPDTDRLPTSHTCFNVLLLPEYSNKEKLKERLLKA 898

  Fly  5141 IHECSEGFG 5149
            | ..::|||
 Frog   899 I-TYAKGFG 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	122/375 (33%)
ube3a	XP_012812141.1	AZUL	58..112	CDD:465173	14/66 (21%)
		HECTc	556..906	CDD:238033	122/377 (32%)