Protein Alignment HUWE1 and Ube3a

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Alignment Length: 1015
• Identity: 222/1015 - (21%)
• Similarity: 372/1015 - (36%)
• Gaps: 247/1015 - (24%)

  Fly  4286 SGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVN 4350
            ||..||........:.....|:||::...:.. :.|||...:.|..|.:..:.:.:|     :::
  Fly    53 SGCGNANCSNANCASSGKVAPMTPNEVAARAL-QLFSQDAQLCEAFTSEANSPQDVD-----MLS 111

  Fly  4351 LTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTS-QAASTSGAAAAT 4414
            ....|.:||......:|:|                          ....||| |:.||..|....
  Fly   112 PNDSSSSSSGSSTSTITSA--------------------------STTTTTSRQSQSTPAAVVVP 150

  Fly  4415 AS------YVP--TVSGAS--------LLPNLA-VHE---------------GIMQDRFT-AEHV 4446
            .|      .||  .::||.        ..|.|| ||.               ....||.. |..|
  Fly   151 VSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGV 215

  Fly  4447 IISAP--------KNAKPTCELQLPSMKKLMSNS--SAQPYFLRTLKIFMQVRDMYEAQNGLSTG 4501
            :.|:.        ::|:|...   .|:::|::||  :.....||||:
  Fly   216 VFSSVDRLGKSFIRSAEPAAS---SSLQELLANSPGALNKEQLRTLE------------------ 259

  Fly  4502 GGVACGAGDNDDDI---IDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDD 4563
                 |..|.|:|.   :|.:.:..|:..::::                  .:..:.:.:|||||
  Fly   260 -----GEHDKDEDSTQQVDEQSESAANATATAE------------------SVESEAEPEEEDDD 301

  Fly  4564 EARS--------FPGV--------GNHAVASASKSTKPTL---SQILCLDVLWNTLSECLVALEE 4609
            ...|        .||:        |....|...|.|...:   ..::.:...|..:..|||..
  Fly   302 VCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVIC-- 364

  Fly  4610 SKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQE 4674
              .:.|.......|:..:|.....:.....|.......|....:.||..:..:..|.||......
  Fly   365 --FDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQIT 427

  Fly  4675 YSPFMDDVSSANTPSSASFDD-----------EPRMQDASTNTPLVTNPSTSTA----------- 4717
            ....:|:.|.....|..|...           ...::..|...||......:||
  Fly   428 LQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLF 492

  Fly  4718 -----MSAHEAQLRQD-------------RQKFLQFAEKHRTVLNQILRQSPTHLSDGPFA---- 4760
                 :..|..:..:|             |:..:...|.:...|::.::....:||....|
  Fly   493 VYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESE 557

  Fly  4761 ----------------VLVDHTRI--LDFDVKRKYFQTELERL-----------DEGIRREEHTV 4796
                            :|...|::  |.:|.:.:.:......|           .|...|.:..:
  Fly   558 IGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKL 622

  Fly  4797 SVRRVTVFEDS---FRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALF 4858
            :|||..:..|:   ..::....|::.|.:..:.|..|:|.|.||:.:|::.:|..|||||.:.:|
  Fly   623 TVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMF 687

  Fly  4859 CVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDM 4923
             :...:......|.:...|.   :.|..:|.:|..|:::|..|...|....|:.::|......|:
  Fly   688 -IQQEETNNMWFNATPFENG---AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADL 748

  Fly  4924 ESQDYEFYKG----LDYLMKNDISTLGYELTFSTEVQE-FGVTQIRDLKPNGRDTAVTEENKFEY 4983
            .......||.    ||| ...|:..: :|.||.....: ||.....:|.|||:|..|.:.||..:
  Fly   749 SDWSPALYKSLKSMLDY-QGQDMEEV-FEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELF 811

  Fly  4984 VQLVCQLKMSGSIRQQLDAFLEGF---YDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEY 5045
            |.|.....::.:|.||.:||.:||   .|..|..|  :|..:|:|:|:.|..:.|..:|:.:|.|
  Fly   812 VNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKL--LFRPEEIEMLVCGSREFDFVELENSTVY 874

  Fly  5046 H-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRST 5109
            . .||.||..||.||..:.:....|:.|.|:|.||:::||:.|...|       :..|.|....:
  Fly   875 EGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL-------RLLITRHGPDS 932

  Fly  5110 DRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            ||||.:|||||.|.||.|.|.:||...|:|||: .|:|||
  Fly   933 DRLPTSHTCFNVLLLPEYSSREKLEERLMKAIN-YSKGFG 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	114/364 (31%)
Ube3a	NP_648452.1	AZUL	40..94	CDD:465173	10/41 (24%)
		HECTc	620..971	CDD:238033	114/366 (31%)