Protein Alignment HUWE1 and Herc4

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 1084
• Identity: 234/1084 - (21%)
• Similarity: 392/1084 - (36%)
• Gaps: 334/1084 - (30%)

  Fly  4315 KIY---SKNFSQL----------------------QLVIEVLTHQCGTTEGL------------D 4342
            |:|   |.::|||                      .::|::.   ||:...|            |
  Fly    60 KVYACGSNDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQIC---CGSRHSLALSDWGQVLSWGD 121

  Fly  4343 NVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIH-----------QG 4396
            |         .|.|...|     ....|:.|.:.|||.:...:.:|...|.|           ..
  Fly   122 N---------DCGQLGHA-----TDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSW 172

  Fly  4397 GAGTTSQAASTSGAAAATASY---VPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNA---- 4454
            |:....|....|.......:|   :.|:.|   :|..|:..|       ..|..:.:...|
  Fly   173 GSNIYGQLGVNSPNDLTHCNYPLRLTTLLG---IPLAAIACG-------GNHSFLISKSGAVFGW 227

  Fly  4455 -KPTCELQLPSMKKLMSNSSAQPYFLRTLKI-FMQVRDMYEAQNGLSTGGGV-ACGAG------- 4509
             :..|. ||....:...:...|...||||.: |:...|.:..  .|:..||| .||||
  Fly   228 GRNNCG-QLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSV--FLTNEGGVFTCGAGAYGQLGH 289

  Fly  4510 ---DNDD------------------------DIIDIEGDGGASG-GSSSDMAPGSASTISPPPPM 4546
               .|:.                        .::...|...|.| |||..:...|..::..|..:
  Fly   290 GFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVV 354

  Fly  4547 ETNQIAQDGDDDEEDDDEARS------FPGVGNHAVASAS-----------KSTKPTLSQILCLD 4594
            ....::..|....:.:|...|      |.| |:.::.:.:           ::..|. ||||.|.
  Fly   355 IGPWVSPSGSALLQSNDSQVSLVIRQIFSG-GDQSIVTTTLFVDKVPPEDFRNYNPK-SQILTLT 417

  Fly  4595 V-LWNTLSECLVALEESKDEFAVLVLQPTVEA-----FFLIHASHRGASKKSGRSFMPNAAGFGL 4653
            . :....::|...|:...|..:.:.|....:|     |.|.|..|.|.|.::        .|..|
  Fly   418 AEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRN--------HGLDL 474

  Fly  4654 RAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPS--SASFDDEPRMQDASTNTPLVTNPSTST 4716
            :||..|                   .|::.:....|  ...:|:..:....|    ||.:|:...
  Fly   475 KAAQLA-------------------FDNLRAVENESIRQVIWDNITKELVGS----LVCSPADVE 516

  Fly  4717 AMSA-------HEAQLRQDRQKFLQ---------FAEKHRTVLNQILRQSPT----HLSDGPFAV 4761
            :|..       ||. :.....|.||         .||..|.|||:.|.|:|.    ||......|
  Fly   517 SMRLYLLLPLYHEF-VNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHV 580

  Fly  4762 LVD---------------------------------------------HTR----------ILDF 4771
            ::.                                             |.|          :.|:
  Fly   581 VIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDY 645

  Fly  4772 -DVKRKYF------------------------QTELERLDEGIRREEH----------------- 4794
             ||:::|.                        :|.|.:.|:.::....
  Fly   646 ADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMP 710

  Fly  4795 -----TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPM 4854
                 .::|.|..:.:||.|.|......:.|....|.|..||.:||||:.:|:::::.:::.:|.
  Fly   711 ISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPK 775

  Fly  4855 YALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVK 4919
            |.:|......|:.:..:.:.....   .|| .:|.:...|:::..::...|..:.:|.:|||.|.
  Fly   776 YGMFKEYEQSRLLWFADLTFETEN---MYF-LIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVD 836

  Fly  4920 HTDMES---------QDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAV 4975
            .:|:..         |....|:|.|:   .::    ::|||......||..:.:.|||||.:.||
  Fly   837 LSDLRQLSPPEANSMQSLLDYQGDDF---KEV----FDLTFEISRDVFGEAETKCLKPNGNEIAV 894

  Fly  4976 TEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLK 5040
            |.||:.|:|.|......:.|:....:||.:||..:....:|.||..:||..::.|..|.|.:.|:
  Fly   895 TLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQ 959

  Fly  5041 ANTEYHK-YTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHR 5104
            .|.||.: |||....|:|||..:....:|::..||.|:||:.::|:||..:|:     ...|...
  Fly   960 DNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALK-----LTIQPTP 1019

  Fly  5105 DDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            |:|.   ||.||||||.||||.||:.::|:..||:||.: ::||
  Fly  1020 DERF---LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQ-TQGF 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	111/363 (31%)
Herc4	NP_001261249.1	ATS1	7..352	CDD:444065	60/321 (19%)
		RCC1	327..390	CDD:395335	14/63 (22%)
		HECTc	715..1060	CDD:238033	111/365 (30%)