Protein Alignment HUWE1 and Ube3a

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_061511705.1
• Gene: Ube3a / 3291570
• VectorBaseID: AGAMI1_003809
• Length: 1059
• Species: Anopheles gambiae
• Alignment Length: 1182
• Identity: 259/1182 - (21%)
• Similarity: 438/1182 - (37%)
• Gaps: 349/1182 - (29%)

  Fly  4041 GGAGSGSAASGGLTGYDDVPPGGTLD---FRSRFC--RYQVVNRLRSIFDDHPAPKPSVPLDEA- 4099
            |.:||.|..|..:....:.|.....|   .|.|.|  ..:.|.::...:|:......|:..|::
Mosquito   152 GSSGSTSTCSPSVAQGSNEPSSADADRSNARWRECSKENKEVEKMDVAYDNSALDLDSMEEDDSS 216

  Fly  4100 ------------PSTSKAAAAK--------------------AAATAKVSTAGSQNKHSVPYQTN 4132
                        ||:|.::::.                    .||.::.:..||.:......:|.
Mosquito   217 TKTTGSTAEPRKPSSSSSSSSSNTSHNTAQNHLEPLAAVGTLPAANSRNNNVGSSSGSGAKTKTQ 281

  Fly  4133 AK---NFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVI 4194
            |.   .:.|..: :.:.|:..:...:..||.......:........||...|....:|    |::
Mosquito   282 ATEEVQYLDEAM-LKELTERCIREGSDAPLIRTLGAVFSSYRGLAASFQFCPAASSIE----KML 341

  Fly  4195 CRSP--HLTDMLVKLLASLSTELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAE 4257
            .|:|  .|.:|..:.|.||..:|.|:|      |...|:..:               |....||.
Mosquito   342 ARAPAGDLRNMKKEDLRSLEGDLDKDE------DSKAPVESV---------------PDVPDPAH 385

  Fly  4258 NTATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFS 4322
            .|.....:...:.|..  .|.||...|.   :||      |..|..:|    |:..|...:.| .
Mosquito   386 TTVDVESLRSSMKALY--AARPAVFGPI---NNA------LELLGKSL----SRDLRVGLTSN-D 434

  Fly  4323 QLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGL------------AE 4375
            :|:.::.|......|         |:|....|.:.|    ...:.||:..|            ||
Mosquito   435 ELESLVTVFVIAFET---------LLVGSADCLEGS----FPRICAAVTRLPVWAQCRLVRIWAE 486

  Fly  4376 EVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVH--EGIMQ 4438
            ..:.:|..||.:::.                           :.|||      .|::|  .||
Mosquito   487 HCKDSIHPLLQQLQQ---------------------------LITVS------TLSMHSFRGI-- 516

  Fly  4439 DRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGG 4503
             |.....|:.:|.|           :||.:        |:...|...::.:...|
Mosquito   517 -RIHDNKVVCNATK-----------AMKLV--------YYANILAGELEPKHYRE---------- 551

  Fly  4504 VACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSF 4568
                        :|:.           |.:..|..::.|           :.||....|.|.||
Mosquito   552 ------------LDLR-----------DTSLPSYLSLIP-----------EDDDVRPADAEVRS- 581

  Fly  4569 PGVGNHAVASASKSTKPTLSQILCLDVLWNTLSEC---LVALEESKDEFAVLVLQPTVEAFFLIH 4630
                     ...|...|.:::   |||  |.| :|   ||..||..:|....|          :.
Mosquito   582 ---------RQKKVEDPFITE---LDV--NPL-DCRKPLVPYEEFYNELLCDV----------VE 621

  Fly  4631 ASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSA-SFD 4694
            ..|.....||             .|:|..||:..:|                   ..||:. ||
Mosquito   622 MDHDYLEYKS-------------IASAVNGALSLIG-------------------TDPSTIFSF- 653

  Fly  4695 DEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHL-SDGP 4758
                ||.|     .:..|:|.|....:::::|...::.|.|.::     .|.|||:.:.| :..|
Mosquito   654 ----MQYA-----FILTPTTKTLALYYDSRIRMYSERRLSFLQQ-----QQQLRQNSSALQAVNP 704

  Fly  4759 FAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDS---FRVLYRLGPEEWK 4820
            :.                                  .:.:||..:.:|:   ..::....|::.|
Mosquito   705 YL----------------------------------NLKIRRDHIIDDALVELEIIAMSNPKDLK 735

  Fly  4821 NRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFK 4885
            .:..:.|..|:|.|.||:.:|::.:|..|||||.|.:| |:..|..|...|..|..|.   :.|.
Mosquito   736 KQLVVEFTGEQGIDEGGVSKEFFQLIIEEIFNPDYGMF-VTNEDSNTVWFNSISFENE---AQFT 796

  Fly  4886 FVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLM---KNDISTLGY 4947
            .:|.|:..|:::|.:|...|....|:.::|.:....|::..:...:..|..|:   :||:..: :
Mosquito   797 LIGIVLGLAIYNNIILAVNFPMVVYRKLMGMKGSFLDLKDLNPVLFNSLKSLLDYTENDMEEV-F 860

  Fly  4948 ELTFSTEVQE-FGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFY--- 5008
            ..||....:: ||.....:|||:|....||::||.::|:|.....::.|:.:|.:||..||.
Mosquito   861 MQTFKIGYRDVFGNLLEHELKPDGDKIFVTQDNKQDFVELYSDFMLNKSVEKQFNAFRRGFQMVT 925

  Fly  5009 DIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAK 5072
            |..|.||  :|..:|:||::.|..:.|.::|:.:|||. .:|::|..|:.||..:.......:.|
Mosquito   926 DESPLHL--LFRPEEVELIVCGSKEFDFDELEQSTEYEGGFTAESQTIKDFWSIVHGLSMEVKRK 988

  Fly  5073 FLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCL 5137
            .|||.||:.:||:.|...|       |..:.|:...:||||.:|||||.|.||.|.|.:||...|
Mosquito   989 LLQFTTGSDRVPVGGLSRL-------KLVVARNGPDSDRLPTSHTCFNVLLLPEYNSKEKLEERL 1046

  Fly  5138 LKAIHECSEGFG 5149
            ||||: .|:|||
Mosquito  1047 LKAIN-YSKGFG 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	114/363 (31%)
Ube3a	XP_061511705.1	None