DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and Smurf2

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001100531.1 Gene:Smurf2 / 303614 RGDID:1310067 Length:748 Species:Rattus norvegicus


Alignment Length:463 Identity:181/463 - (39%)
Similarity:258/463 - (55%) Gaps:50/463 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  4696 EPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFA 4760
            :||:   |.|..||.|         .:.||:..:|:             |::...|         
  Rat   327 DPRL---SANLHLVLN---------RQNQLKDQQQQ-------------QVVSLCP--------- 357

  Fly  4761 VLVDHTRILDFDVKRKYFQTELERLDEGIRREE----H-TVSVRRVTVFEDSFRVLYRLGPEE-W 4819
               |.|..|.....::....:|:.|.:.:.:::    | .:.|.|..:||:|:|.:.::.|:: |
  Rat   358 ---DDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLW 419

  Fly  4820 KNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYF 4884
            | |..|.|..|||.|.||:.|||..::|.|:.||.|.||..|..|..|..|||.|..||.|||||
  Rat   420 K-RLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYF 483

  Fly  4885 KFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYEL 4949
            .||||::..||.....::..||..|||.:|||.:...|||..|.:.:..|.::::|||:.: .:.
  Rat   484 HFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV-LDH 547

  Fly  4950 TFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKH 5014
            ||..|...:|.....:|||||:...||||||.|||:|....:....|..|..|..:||.::||:|
  Rat   548 TFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQH 612

  Fly  5015 LISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTG 5079
            |:..|:|:||||:|.||..||:.|.||||.....|..|..::|||:|:..||:..||:.||||||
  Rat   613 LLKTFDEKELELIICGLGKIDVSDWKANTRLKHCTPDSNVVKWFWKAVELFDEERRARLLQFVTG 677

  Fly  5080 TSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHE- 5143
            :|:||||||.:|:|..|.:.|.||:.|..|:.||.||||||::|:|.|:||:||...||.||.| 
  Rat   678 SSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEET 742

  Fly  5144 CSEGFGFA 5151
            |    |||
  Rat   743 C----GFA 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 160/354 (45%)
Smurf2NP_001100531.1 C2_Smurf-like 13..137 CDD:176028
PRP40 155..>236 CDD:227435
WW 159..188 CDD:459800
WW 252..283 CDD:197736
WW 298..330 CDD:197736 1/2 (50%)
HECTc 393..745 CDD:238033 160/357 (45%)
Blue background indicates that the domain is not in the aligned region.

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