Protein Alignment HUWE1 and Arel1

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001100214.1
• Gene: Arel1 / 299197
• RGDID: 1307597
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 592
• Identity: 172/592 - (29%)
• Similarity: 270/592 - (45%)
• Gaps: 95/592 - (16%)

  Fly  4613 EFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSP 4677
            ||.::||....:.....:.|..|.|... .:::.||..:.                  ||..:.|
  Rat   270 EFDIIVLSENEKNIVERNVSTSGVSIYF-EAYLYNANSYS------------------SAPWHLP 315

  Fly  4678 FMDDVSSANTPSSASFDDEPRMQDASTNTP-LVTNPS------TSTAMSAHEAQLRQDRQKFLQF 4735
            .|...||...||:| .::|.....:..:|| .|..|.      :....|..|..|:....:...|
  Rat   316 PMHMSSSQRRPSTA-LEEEEEDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTF 379

  Fly  4736 AEKHRTVLNQILRQSPTH------LSDG---PFAVLVDHTRIL----------------DFDVKR 4775
            .....|..: .|...|.|      :.||   |..:......||                .|..|.
  Rat   380 RVCPGTKFS-YLGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKV 443

  Fly  4776 KYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLR 4840
            .:||.||.::.......:.|:.|.|..:.|.|.:........:|...|.:||:|||..|.||..|
  Rat   444 NFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRR 508

  Fly  4841 EWYVIISREIFNPMYALFCVSPGDRVTYMINPSS--HANPN-----HLSYFKFVGRVIAKAVHDN 4898
            ||:.:|.:.:|:....||       ..:..|..:  |.|||     .|..::|.||::.|.::::
  Rat   509 EWFELICKALFDTTSQLF-------TRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYES 566

  Fly  4899 KLLECY-------FTRSFYKHILGKQVKHTDMESQDYEFYKG-LDYLMKNDISTLGYELTFSTE- 4954
            .|...|       |||||...|:|.::.:...|:.|.||||. :.:::.||:|.:  ||.|:.|
  Rat   567 SLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEM--ELVFAEEK 629

  Fly  4955 VQEFG-VTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISI 5018
            ..:.| :.:|.:|...|..|.||..||..|:.|:.|.:::..::::::.||:|..:::|::|::|
  Rat   630 YNKSGQLDKIVELMTGGAQTPVTNANKTFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAI 694

  Fly  5019 FNEQELELLISGLPDIDIEDLKANT-----EYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVT 5078
            |:|.|||||:.|..||.:.|.||:.     .:|   .:...::|||..:.|..|.:.|:.|||.|
  Rat   695 FDENELELLMCGTGDISVSDFKAHAVVVGGSWH---FREKVMRWFWTVVSSLTQEELARLLQFTT 756

  Fly  5079 GTSKVPLQGFGSLEGMNGIQKFQ-IHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIH 5142
            |:|::|..||.:|     ...|| |.....||  ||.||||||||.||.|.||:::...|..||.
  Rat   757 GSSQLPPGGFAAL-----CPSFQIIAAPTHST--LPTAHTCFNQLCLPTYDSYEEVHRMLQLAIS 814

  Fly  5143 ECSEGFG 5149
            |..||||
  Rat   815 EGCEGFG 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	127/375 (34%)
Arel1	NP_001100214.1	Filamin	56..154	CDD:395505
		HECTc	486..820	CDD:214523	122/352 (35%)