Protein Alignment HUWE1 and Hectd2

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_001156943.1
• Gene: Hectd2 / 226098
• MGIID: 2442663
• Length: 775
• Species: Mus musculus
• Alignment Length: 824
• Identity: 200/824 - (24%)
• Similarity: 332/824 - (40%)
• Gaps: 170/824 - (20%)

  Fly  4407 TSGAAA----ATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAK---PTC------ 4458
            |:||||    .:...:.|.|  |.:..:...:...::|.:..|:.:...:|.:   |.|
Mouse    39 TAGAAAGLDRGSKGQISTFS--SFVSTVTQKKEAAENRSSPTHLALPNIRNVRDLPPICLDVRQK 101

  Fly  4459 ----------ELQLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDD 4513
                      |:::|.:.:  .:..:||   :|:|.|.:..:..||.....|.......|.|:..
Mouse   102 QRMSVEALPSEVKVPPLPE--PSLPSQP---KTVKDFEEDLEKAEATGNWKTVHAFYITAFDSFT 161

  Fly  4514 DI-IDIEGDGGASGGSSSDMAPGS-------ASTISPPPPME-------TNQIAQDGDDDEEDDD 4563
            :: ...:.|..||..:..|....:       .:.::.|..::       .|.:.|:.......||
Mouse   162 ELNTAFKKDATASFNTIEDSGLNANLVNAVFDALLNTPQDIQKSVLKGIINSLLQEWKGPRTKDD 226

  Fly  4564 EARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQ--PTVEA- 4625
            ....|                     ||..:..:|..|..::        :|.|:.|  ..|||
Mouse   227 LRAYF---------------------ILLQNPQFNITSTYVI--------YAHLLRQIATLVEAD 262

  Fly  4626 -FFLIHASHRGASKKSGRSFMPNAAGF-GLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTP 4688
             .||:|...: .|:|..:..:.....| .||          |..|.|  :|:.|...  .:...|
Mouse   263 HHFLVHWLKK-LSQKKFKQLVERLLQFVSLR----------LFPAKP--EEFPPLTK--CTWWIP 312

  Fly  4689 SSASFDDEPRMQDASTNTPLVTNPSTSTAMSA-HEAQLRQDRQKFLQFAEKHRTVLNQILRQSPT 4752
            |:|.........:...:.|||  |.|....|. ....|.::...:..|...|          |..
Mouse   313 SAAKVLALLNTANNLVHPPLV--PYTDFYNSTLDHIDLMEEYHTWQSFGNSH----------SRF 365

  Fly  4753 HLSDGPFAVLVDHTR-ILDFDVKRKYFQTELERLDEGIRREEH--------TVSVRRVTVFEDSF 4808
            .....||.:.:...: |:..|.:::......:.|.:.:.|.:.        .:.|||..:..||.
Mouse   366 SFCQYPFVISIAAKKIIIQRDSEQQMISIARQSLVDKVSRRQRPDMNMLFLNMKVRRTHLVSDSL 430

  Fly  4809 RVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPS 4873
            ..|.| ...:.|.:..:.|..|.|.|.|||.:||::::.|:||:|.|.:|        ||  :..
Mouse   431 DELTR-KRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMF--------TY--HKD 484

  Fly  4874 SHAN------PNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMES------- 4925
            ||.:      .::.|.|:.||.::..||:::..|:..|....||.:|...|..:|..:
Mouse   485 SHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPVVPSDQSTPVGICSV 549

  Fly  4926 --QDY-----EFYKGLDYLMKNDISTLGYE--------LTFSTEVQEFGVTQIRDLKPNGRDTAV 4975
              .|.     |...||..|       |.||        .||....:||||.:..:|||.|....|
Mouse   550 TIDDLCQVMPELAHGLKEL-------LSYEGNVEEDFYSTFQVFQEEFGVIKSYNLKPGGDKIPV 607

  Fly  4976 TEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLK 5040
            |.:|:.|||||.....::.||.:|..||..||:.:...:.:.:...:|:|:|:.|.|::|:..|:
Mouse   608 TNQNRREYVQLYTDFLLNKSIYKQFAAFYCGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQ 672

  Fly  5041 ANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRD 5105
            .:|:|..|......|::||..:..|....:.|.|.|.||:.:||:.|...|       .|:|.::
Mouse   673 RSTQYDGYAKTDLTIRYFWDVVLGFPLELQKKLLHFTTGSDRVPVGGMADL-------NFKISKN 730

  Fly  5106 DRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            :.||:.||.||||||||.||.|||...|:..|:..|.. |||||
Mouse   731 ETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISN-SEGFG 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	121/380 (32%)
Hectd2	NP_001156943.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		5/11 (45%)
		HECTc	416..773	CDD:238033	121/382 (32%)