DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HUWE1 and oxi-1

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_499392.1 Gene:oxi-1 / 176515 WormBaseID:WBGene00003898 Length:1066 Species:Caenorhabditis elegans


Alignment Length:939 Identity:214/939 - (22%)
Similarity:341/939 - (36%) Gaps:252/939 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  4315 KIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAIL-GLAEEVR 4378
            ||:.|....|:...|.:      ..|:|  .:|::||     .::.:...|:....| ....|..
 Worm   274 KIFEKTLHWLRANAEEI------ETGMD--VRLLINL-----LANLVHFAYINDKTLESKLYEWT 325

  Fly  4379 QAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEG-------- 4435
            .|:.:.|:......:..||..|             :..|...|.|..|||.....||        
 Worm   326 WAVGVSLSRCTELTVKHGGTKT-------------SLHYWHPVFGHYLLPIDKRTEGALRNVLFQ 377

  Fly  4436 ----------------IMQDRFTAEHVIISAPKNAKPTCELQLPSMKKL---------MSNSSAQ 4475
                            ||::..||...:....||:|..........:||         .|.|.::
 Worm   378 LKMLWSSRVVRCLFGNIMENTKTASFSVTDGQKNSKDISAAFSKLWRKLGGSTDSASSSSKSESE 442

  Fly  4476 P----------YFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDI---------EGD 4521
            |          .::..|...:.::.  |..:||       |    .||.::..         |..
 Worm   443 PPPTLIAIVCQVYMTALNTMVHMKG--EIISGL-------C----RDDQLLKQLWTYLREWGEKA 494

  Fly  4522 GGASG-----GSSSDMAPGSAS--TISPPPPMETNQIAQDGD---------DDEEDDDEARSFPG 4570
            ||.||     .::....|.|||  ::..|....|..:....|         |:||..::...|  
 Worm   495 GGTSGSIFNSSNAEQWGPVSASLQSLKRPSSPHTATLRLFVDCAAAIISILDEEEIFEKETPF-- 557

  Fly  4571 VGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRG 4635
             .|..:.|..|..     .|.|...:|:.      |::|:           :.....|.|:.|..
 Worm   558 -SNKELESICKYV-----NIFCFRSIWSG------AVDET-----------SANTTGLFHSMHSL 599

  Fly  4636 AS----KKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDE 4696
            .:    :.|.|||..|.:.|.|                            :|... |||.:.:.|
 Worm   600 LTVLYERDSRRSFAANDSKFWL----------------------------ISEVK-PSSLTIEYE 635

  Fly  4697 PRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAV 4761
            .:             ......|....|.|...:.:.|.|..:.:...|::    .|.|:|     
 Worm   636 KK-------------SGKGVLMMRKMAHLVPIKDRMLLFRRQVQDDKNRV----ATSLND----- 678

  Fly  4762 LVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIV 4826
                          ...||              .::|:|..:.||.|..|.:|.....|:...:.
 Worm   679 --------------PQMQT--------------WITVQRNRIIEDGFNHLSKLTIPALKSTIRVK 715

  Fly  4827 FEDEEGQD-AG----GLLREWYVIISREIFNPMYALF-CVSPGDRVTYMINPSSHANPNHLSYFK 4885
            |.:|:|.| ||    |:.:|:..:..:::|:|...|| ..|.|  |.|. :|:|..:.:||:.|.
 Worm   716 FVNEQGLDEAGIDQDGVFKEFLELTLKKVFDPQLNLFSTTSTG--VLYP-SPTSSLHDDHLALFT 777

  Fly  4886 FVGRVIAKAVHDNKLLECYFTRSFYKHILG--KQVKHTDMESQDYEFYKGLDYLMKNDISTLGYE 4948
            ||||::.|||::..:::..........:||  :.....::...|.|.|:.|.::.:.:.......
 Worm   778 FVGRMLGKAVYEGIVVDVQLAPVLLAAVLGSHRLCAFDELSQLDPELYRSLTFVKRYEGEMADLS 842

  Fly  4949 LTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPK 5013
            ||||.:....|.....||.|:||..:||.|||.:||..:...::....::|..||:.|...|:..
 Worm   843 LTFSVDEDFMGKISTVDLVPSGRTISVTNENKIDYVHRMAHHRVFRRTQEQCKAFVTGMQSILQP 907

  Fly  5014 HLISIFNEQELELLISGL-PDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRS-FDQADRAKFLQ 5075
            ..:|:|...:|:.||||: .|||:.|||.|.:|. .:......|:|.|..|.: |...:|..||:
 Worm   908 TWLSLFAPNDLQCLISGVNSDIDLADLKRNVQYFGGFHGNHRLIKWLWDILENKFTSEERKLFLK 972

  Fly  5076 FVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTD-------------------RLPCAHTCFNQ 5121
            |||..|:.|:.||..||....|:..::..|....|                   |||.|.||||.
 Worm   973 FVTSCSRPPVLGFSYLEPPFSIRCVEVSDDQDQGDTLGSVVRGFLALRKGTAATRLPTASTCFNL 1037

  Fly  5122 LDLPMYKSYDKLRSCLLKAIHECSEGFGF 5150
            |.||.|.....|...|..|||   .|.||
 Worm  1038 LKLPNYNKKSLLLEKLRYAIH---AGTGF 1063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 117/382 (31%)
oxi-1NP_499392.1 HECTc 684..1064 CDD:238033 119/386 (31%)
Blue background indicates that the domain is not in the aligned region.

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