Protein Alignment HUWE1 and LOC1280030

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_061512305.1
• Gene: LOC1280030 / 1280030
• VectorBaseID: AGAMI1_012596
• Length: 999
• Species: Anopheles gambiae
• Alignment Length: 1105
• Identity: 289/1105 - (26%)
• Similarity: 450/1105 - (40%)
• Gaps: 221/1105 - (20%)

  Fly  4126 SVPYQTNAKNFWDVVLNIDQQTQVRLANVAQFPLTSQPAWEWQ------PNTA------DFLSF- 4177
            |:..:|:.|.  |::.|                 |:.|.|..:      |.:.      |..||
Mosquito    33 SIDGKTSRKT--DIIKN-----------------TNTPKWNERFTSIVSPGSVLHFRVLDHSSFR 78

  Fly  4178 SESPFGQ--------------LLEMLPYKVICRSPHLTDMLVKLLASLSTELPKEE----ELLPL 4224
            .:|..||              :||:|...:        |:|:....|..|..|::.    ||:.:
Mosquito    79 KDSLLGQQTVELAGILRHYNGVLELLELNM--------DLLIDGTGSSKTSEPRQPVKAGELVVV 135

  Fly  4225 SDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEIGDGLAANIEEQASPASGNPASGDS 4289
            .|.:..     .::..||.|.|..           ...|..|.|: .|:..|.|       .|.|
Mosquito   136 LDGLKI-----DMRHLGAGAGAMR-----------GNETGTGSGM-VNVNGQLS-------GGPS 176

  Fly  4290 NAGAKRTQLPTLSVALPVTPSKPRRKIY----SKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVN 4350
            :.........||..::.....:.|.::.    .....|||       ....:|.|:.|.|
Mosquito   177 DLAPNGVHYHTLRSSILNGGIRARMRLRGTGGGSTSQQLQ-------PASSSTGGMMNHA----- 229

  Fly  4351 LTQCSQASSAIF---------IQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAAS 4406
            |...|.:|||..         ..:.:.:...........:...|||   ::|..|..||......
Mosquito   230 LVPSSSSSSAAVQHHQSQHSPASHASQSNNNATSTASDCVSSSLNE---FSIAGGSYGTMGNGIM 291

  Fly  4407 TSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSN 4471
            |:|::........:.||||.........||..|:.....|..|...:|:         :..:.||
Mosquito   292 TAGSSPNGGGGGGSSSGASSSTGAIRRSGINWDQQNVSPVASSTGYHAR---------LGPVYSN 347

  Fly  4472 SSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEG--DGGASGGSSSDMAP 4534
            ||                     |.||..|   ..|.|..:..::.:.|  .|||:.|..:|:
Mosquito   348 SS---------------------QEGLING---VPGGGHTNTAMLPVAGGSPGGANNGGGADI-- 386

  Fly  4535 GSASTISPPPPME---TNQ--IAQDGDDDEEDDDEARSFPGVGNHAVASASK------STKPTLS 4588
                    |.||.   |:|  |.|.....:::..:....|......|....:      :|:.|
Mosquito   387 --------PMPMGGSLTDQQLILQHQQQQQQNPIDDEPLPAGWEMRVDKFGRRYYVDHNTRST-- 441

  Fly  4589 QILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFF-----------------LIHASH-RG 4635
                   .|..........|:.:|        |....::                 |:|..| :|
Mosquito   442 -------YWEKPQPLPAGWEQRRD--------PRGRVYYVDHNTRTTTWQRPNSERLMHFQHWQG 491

  Fly  4636 -----ASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDD-VSSANTPSSASFD 4694
                 .|:.:.|...|..|......:.......||| ..|...|.....|: |...|..:..:..
Mosquito   492 QRQHIISQGNQRFLYPQHAQQSNSISVAHEEDDGLG-PLPDGWEKRVQPDNRVYFVNHKNRTTQW 555

  Fly  4695 DEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPF 4759
            ::||.|....:. |...|    .....|.:...:.::|.......:|........:|.. :.|.:
Mosquito   556 EDPRTQGQEVSM-LAEGP----LPPGWEIRYTANGERFFVDHNNRKTTFEDPRPGAPKG-AKGVY 614

  Fly  4760 AVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFY 4824
            .|...:.|...:.:.:..:..:...|...|:     :::.|.|:||||:..:.||...|.:.|.|
Mosquito   615 GVPKAYERSFRWKLSQFRYLCQSNALASHIK-----ITLTRQTLFEDSYHQIMRLPAYELRRRLY 674

  Fly  4825 IVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGR 4889
            |:|..|||.|.||:.|||:.::|.|:.||||.||..:..:..:..|||:|:.||:||.||||:||
Mosquito   675 IIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIGR 739

  Fly  4890 VIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTE 4954
            .||.|::..:.:...||..|||.:|.|::...|:|:.|.|||..|.::..|:|...|.||.||.:
Mosquito   740 FIAMALYHGRFIYSGFTMPFYKRMLNKKLTTKDIETIDPEFYNSLIWVRDNNIDECGLELWFSVD 804

  Fly  4955 VQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIF 5019
            .:..|.....:||.||....||||||.||:.|:.:.:|:..|.:|...||:||.:::|...:..|
Mosquito   805 FEVLGQIIHHELKDNGDKERVTEENKEEYISLMTEWRMTRGIEEQTKTFLDGFNEVVPLEWLKYF 869

  Fly  5020 NEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVP 5084
            :|:||||::.|:.:||::|.:.|:.|..|...|.|:.|||:.:|..|...||:.|||||||.:||
Mosquito   870 DERELELMLCGMQEIDVDDWQRNSIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRVP 934

  Fly  5085 LQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            :.||..|.|.||.|:|.|.:..:.| .||.:|||||:||||.|||||:|...|..||.| :||||
Mosquito   935 VGGFAELMGSNGPQRFCIEKVGKDT-WLPRSHTCFNRLDLPPYKSYDQLVEKLNYAIEE-TEGFG 997

  Fly  5150  5149
            Mosquito   998  997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	154/352 (44%)
LOC1280030	XP_061512305.1	None