Protein Alignment HUWE1 and LOC1278379

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_061509954.1
• Gene: LOC1278379 / 1278379
• VectorBaseID: AGAMI1_014125
• Length: 1127
• Species: Anopheles gambiae
• Alignment Length: 1124
• Identity: 247/1124 - (21%)
• Similarity: 410/1124 - (36%)
• Gaps: 335/1124 - (29%)

  Fly  4143 IDQQTQVRLANV---AQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDML 4204
            ||:.| ..|||.   |.|.:..:|.........|.||      .|:|:...:.|:  ||.|:|.
Mosquito   220 IDEDT-TALANPIADALFEMLLRPLQLIDTEARDTLS------RQILQSFTFNVL--SPQLSDQ- 274

  Fly  4205 VK--LLASLS--TELPKEEELLPLSDQMPPLVPIGPVQRAGAAAAAAHPPPPQPPAENTATATEI 4265
            ||  :|.:|.  |:.|....:...:|:...|:..                          .:|.:
Mosquito   275 VKHFVLPALGERTDFPYWTLVRHTADEYQGLLDY--------------------------RSTIL 313

  Fly  4266 GDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPR----------RKIYSKN 4320
            .|....:.::..:|....|..                     ||.|.|          |...|..
Mosquito   314 VDLTTEDDDDGTAPMGSRPVG---------------------TPKKARTTNRVQDERLRLTSSLL 357

  Fly  4321 FSQLQL----VIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAI 4381
            :|.|:|    |.|..|.:......|..||.::.|:|:..:                  :.:|.:|
Mosquito   358 YSLLKLDERHVDETSTSKEHFRAYLKVVASMVDNITKLPR------------------KTIRSSI 404

  Fly  4382 QMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLA--VHE--GIMQDR-- 4440
            ...|::              |..:.:.|.           .|.:|.|..|  :|.  |::.:|
Mosquito   405 NRPLDD--------------SSDSDSDGE-----------DGPALGPREAALLHAVIGMLNERRR 444

  Fly  4441 --FTAEHV--IISAPKNAKPTCEL--QLPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLS 4499
              ||...:  ::..|...:..|::  ||.:..::........|.|.:..:.  :|.::......|
Mosquito   445 VSFTVRLIDTVLDDPLAVQHLCQICHQLMTYNRMAVYEYKLLYMLASKPLI--IRGLWYTLTAHS 507

  Fly  4500 TGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDE 4564
            ||                                    ...|.|    ..::::..:..:||.|.
Mosquito   508 TG------------------------------------QLFSSP----IVRLSKGINISKEDSDR 532

  Fly  4565 A----RSFPGVGNHAVAS------ASKSTKP-TLSQILCLDV-----LWNTLSECLVALEESKDE 4613
            .    .||..:....:||      ..::..| |:|.|:...:     |..||.|..:.|.|
Mosquito   533 TIPILASFCALFGRLIASLHDGEFVQENVLPGTVSSIMPFSIPELIPLSTTLKEISLGLVE---- 593

  Fly  4614 FAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPF 4678
                          |.....|.:..::.|:.:.:.:|...|:..|.|::.|...:.|..|....:
Mosquito   594 --------------LAFPETRSSLHENYRTMISSLSGGEARSFGGTGSLVGRQRSQPYEQNRQIW 644

  Fly  4679 MDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVL 4743
                                        |.:.....|.....|...||:     ....|.|.|..
Mosquito   645 ----------------------------PHLLKVCVSLLRQIHTRDLRR-----CFCPEGHWTAQ 676

  Fly  4744 N-QILRQSPT--HLSDG------PFAVLVDHTR-------------------------ILDFDVK 4774
            | .:....||  |||.|      ||..:.|.||                         ::.|:.:
Mosquito   677 NLNLPLDKPTDLHLSRGSRRGPRPFQPIRDFTREDIEDGPPLSTKQIRSITILREIPFVVPFNTR 741

  Fly  4775 RKYF-----------QTELERLDEGIRREEHTVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFE 4828
            ...|           |.:|:...:|   ....::|||..::||:|..|......:.:.:|.|...
Mosquito   742 VGVFQGLVAADKLRTQGDLQGFLQG---PSIHLTVRRSHLYEDAFDKLSPTNEPDLRPKFRIEMV 803

  Fly  4829 D-----EEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANP-------NHL 4881
            :     |.|.|.||:.||:...:.:..|:|....|.::. |.:.|       .||       :..
Mosquito   804 NSVGLREAGIDGGGVFREFLSELIKLAFDPHRGFFMITK-DNMLY-------PNPCVGKIVEDFQ 860

  Fly  4882 SYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDME-----SQDYEFYKGLDYL--MK 4939
            .::.|:||::.||:::|.|:|......|...:.|   ||:|::     |.|...|:.|..|  .:
Mosquito   861 RHYYFIGRILGKALYENLLVELPLAEFFLSKLAG---KHSDVDVHQLASLDPVLYRNLMSLKAYE 922

  Fly  4940 NDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFL 5004
            .|::.||  |.|:......|.|::.:|||||.:..|...|:.||:||:...|::..||.|..||.
Mosquito   923 GDVADLG--LDFTIVCDALGETKVEELKPNGTNIIVNSTNRIEYIQLMADFKLNQQIRAQCAAFR 985

  Fly  5005 EGFYDIIPKHLISIFNEQELELLISG--LPDIDIEDLKANTEY-HKYTSKSAQIQWFWRALRSFD 5066
            :|..:::|...:.:|:.:||::||||  :| :|:.||:.:|.| ..::.:...||.||:.:..||
Mosquito   986 QGLANVLPIEWLYMFSNKELQVLISGAEIP-VDVHDLRQHTRYGGDFSLEHHTIQLFWKVVEQFD 1049

  Fly  5067 QADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYD 5131
            ...|...|:|||..|:.||.||..|:....||      :...|||||.|.||.|.|.||.::..|
Mosquito  1050 DIQRRLLLKFVTSCSRPPLLGFKDLDPPFYIQ------NAGDTDRLPSASTCMNLLKLPAFEEED 1108

  Fly  5132 KLRSCLLKAIHECSEGFGF 5150
            .||..||.||   ..|.||
Mosquito  1109 VLREKLLYAI---QSGAGF 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	119/374 (32%)
LOC1278379	XP_061509954.1	None