Protein Alignment HUWE1 and LOC1276563

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_315926.2
• Gene: LOC1276563 / 1276563
• VectorBaseID: AGAMI1_014701
• Length: 1082
• Species: Anopheles gambiae
• Alignment Length: 557
• Identity: 150/557 - (26%)
• Similarity: 242/557 - (43%)
• Gaps: 112/557 - (20%)

  Fly  4675 YSPFMDDVSSANTPSSASFDD----------------EPRMQDASTNTPLVTNPSTSTAMSAHEA 4723
            |...:||:......:..:.:|                :.::.||.|.|      |....:|.|..
Mosquito   554 YVTILDDLEMYEQQTPFTLNDYIVLSHFLNTFLYRTIQDQILDAKTAT------SAPLFVSIHTL 612

  Fly  4724 QL---RQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRILDFDVKRKYFQTELERL 4785
            .|   |:|.::  |||..:..::..|   .|:|.             :.|.:..:|:.|..|:::
Mosquito   613 LLCLYRRDCRR--QFAPPNHWLIRDI---RPSHF-------------LADLEKGKKHTQILLQKM 659

  Fly  4786 DEGIRREEHT----------------------------VSVRRVTVFEDSFRVLYRLGPEEWKNR 4822
            ...|..|:..                            |:|.|..:.||.:|.|..|.|...|..
Mosquito   660 PHIIPHEDRVQLFRKFVQNEKAVLGLTESACASPSSALVTVHRDRIVEDGYRQLAALPPHGLKGV 724

  Fly  4823 FYIVF-----EDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLS 4882
            ..:.|     .||.|.|..|:.:|:.....:.:|:|...||..:...|:  ..:|:||...|||:
Mosquito   725 IRVRFINQQGLDEAGIDQDGVFKEFLEETIKRVFDPSLNLFKTTTEQRL--YPSPTSHMQENHLA 787

  Fly  4883 YFKFVGRVIAKAVHDNKLLECYFTRSFYKHILG--KQVKHTDME---SQDYEFYKGLDYL--MKN 4940
            .|:||||::.|||::..:::..|...|...:||  :|..::.|:   |.|.|.|:.|.::  .:.
Mosquito   788 LFEFVGRMLGKAVYEGIVVDVPFASFFLSQVLGQTQQALYSCMDELPSLDKELYRSLTFIKHYQG 852

  Fly  4941 DISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLE 5005
            |::.|  :||||.:....|.....:|.|.||..||..:||..|:..:...:|...||.|..||:.
Mosquito   853 DVADL--DLTFSVDEDVMGKIVTHELHPGGRARAVNNDNKINYIHYMAYFRMHTQIRDQTAAFIR 915

  Fly  5006 GFYDIIPKHLISIFNEQELELLISG-LPDIDIEDLKANTEYH-KYTSKSAQIQWFWRAL-RSFDQ 5067
            ||..|:....:::|:..||:.|||| ...:|::||:.:|:|: .:......:.|.|..| :.|.:
Mosquito   916 GFRCIVNPDWLALFSTPELQRLISGDTSPLDLKDLRKHTQYYGGFHDGHRVVGWLWDILAKDFTE 980

  Fly  5068 ADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDD----------------RSTD---RLP 5113
            .::..||:|||..||.||.||..||....|:..::..|:                |..|   |||
Mosquito   981 EEKKLFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVGDDEDIGDTVGSVIRGFFTIRKKDPLNRLP 1045

  Fly  5114 CAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFGF 5150
            .:.||||.|.||.|:....||..|..||   |...||
Mosquito  1046 TSSTCFNLLKLPNYQKKSMLRDKLRYAI---SSNTGF 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	122/386 (32%)
LOC1276563	XP_315926.2	IQ	32..54	CDD:197470
		HECTc	698..1080	CDD:238033	124/389 (32%)