Protein Alignment HUWE1 and Nedd4

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_061505717.1
• Gene: Nedd4 / 1273805
• VectorBaseID: AGAMI1_001899
• Length: 1056
• Species: Anopheles gambiae
• Alignment Length: 1198
• Identity: 332/1198 - (27%)
• Similarity: 484/1198 - (40%)
• Gaps: 296/1198 - (24%)

  Fly  4095 PLDEAPSTSKAAAAKAAATAKVSTAGS---QNKHSVPY------------QTNAKNFWDVVLNID 4144
            |...|.|...::...:.|.:..:..||   .|:..|.|            :.:...:.|..:.|:
Mosquito     7 PRRRAQSVGNSSYGSSPALSSHTPRGSLFTANEEDVCYVRIRVLGASGLAKKDIFGYSDPYVKIE 71

  Fly  4145 QQTQVRLANVAQFPL-----TSQPAWEWQ------PNTAD--FLSFSES-----PFGQLLEM--- 4188
            |.|.....||.....     |..|.|..:      ||...  |..|.|:     .|..|:::
Mosquito    72 QNTITGDVNVDHMVTKTKRRTLNPVWNEEFVFRVKPNEHKLVFQVFDENRLTRDGFMGLVDLTLI 136

  Fly  4189 -LPYKVICR--SPHLTDMLVKLLASL--STELPKEEELLP--LSDQMPPL----VPIGPVQRAGA 4242
             ||::...|  :|....:..|..:||  ||::....||..  :.|..|.:    ..||...||.|
Mosquito   137 NLPHESDQRTIAPQRYTLRAKRQSSLRVSTKVRGTLELYHAIMRDDDPAIGRTRSAIGGSNRASA 201

  Fly  4243 AAA--AA---------------HPPPPQPPAENTATAT-EIGDGLAANIEEQASPASGNPASGDS 4289
            .:.  ||               ||..||......|:.| :..|.|....|.:..|. |.....:.
Mosquito   202 TSTPLAAHRNAGLYPQQQLPLNHPQHPQHRLHQLASLTAQPNDALPPGWEVRQDPV-GRMYYVNH 265

  Fly  4290 NAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQC 4354
            .|...:.:.||:.      ||:|
Mosquito   266 IARTTQWERPTIG------PSQP------------------------------------------ 282

  Fly  4355 SQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNI----HQGGAGT-----------TSQA 4404
                             ||.|.| .|.|      |.::|    ..||:|:           ||:.
Mosquito   283 -----------------GLNEMV-AAFQ------RRFHISNDPDNGGSGSNNTSMADTVSITSEN 323

  Fly  4405 ASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLM 4469
            ..|:.||....|..|.:....:|              .|:|                 |.:..||
Mosquito   324 GDTTAAAVGNRSGAPGIGSPMVL--------------AADH-----------------PLLSTLM 357

  Fly  4470 SNSSAQPYFLRTLKIFMQVR-------DMYEAQNGLSTGGGVA--CGAGDNDDDIIDIE-----G 4520
            :.|.....|:.|.:     |       |..|...|||....||  ..:|.....|..|.     .
Mosquito   358 AQSGDGGAFVATPE-----RPASAPRGDDAEPTVGLSPSPSVASIASSGAGGTSIRPIRPAPPPP 417

  Fly  4521 DGGASGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEE------------------------- 4560
            .||..||||:..|  .||.:..|.|.:..:.:....:..:
Mosquito   418 PGGGGGGSSASSA--RASPVGTPVPSQRRRSSPGSSESAQATAIEASSGEAGDTTPGPSAPIATA 480

  Fly  4561 DDDEARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEA 4625
            ||::..:...|...|...|..:....:|:.....:    .||...|...::.:.||.| |||
Mosquito   481 DDEQPNASAPVNGSAEGGAPSTVPREVSETATSSI----GSEQTAATTPNRPDTAVAV-QPT--- 537

  Fly  4626 FFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIG-------------------GLGAAAPS 4671
                ..||......:.:   |||.|.....|....:.|                   ||.:..||
Mosquito   538 ----SPSHPTTPAPAAQ---PNATGLPPGWAVQVASNGRLFFIDHINKTTSWVDPRTGLASTIPS 595

  Fly  4672 AQEYSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFA 4736
            |..    .|.|:.....|:|......|....|::..|...|      ...|.::..|.:.|  |.
Mosquito   596 AAG----SDGVAGGGAGSTAGSGHGSRGDSRSSDDNLGPLP------EGWEERVHSDGRTF--FI 648

  Fly  4737 EKHRTVLNQILRQSPTHLSDGPFA-VLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRR 4800
            : |.|...|   .....||:...| ..|.::|  |:..|.:||:::|::......:.:  :.|||
Mosquito   649 D-HNTRTTQ---WDDPRLSNPKIAGQAVPYSR--DYKQKYEYFKSQLQKPSNVPNKID--IKVRR 705

  Fly  4801 VTVFEDSFRVL---YRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSP 4862
            .::.|||:||:   .||  :..|.:.::.||.|.|.|.|||.|||:.::|:|:|||.|.||..|.
Mosquito   706 ASILEDSYRVINSVTRL--DLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSA 768

  Fly  4863 GDRVTYMINPSSH-ANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQ 4926
            .|..|..|||:|. .|..||:||:|:||:...|::..|||:.:|.|.|||.:|.|.:...|||:.
Mosquito   769 MDNYTLQINPNSGLCNEEHLNYFRFIGRIAGMAIYHGKLLDAFFIRPFYKMMLQKSIDLKDMEAV 833

  Fly  4927 DYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLK 4991
            |.|:|..|.|:.:||.|||  .||||.:.:.||.|..|:|||||.|..|:.|||.||::||...:
Mosquito   834 DTEYYNSLLYIKENDPSTL--MLTFSVDEESFGTTNQRELKPNGADLEVSNENKDEYIRLVIDWR 896

  Fly  4992 MSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQI 5055
            ....::.|:.|||||...::|.||:.||:|.|||||:.|:..||:.|.|.||.|. .|.:..|.:
Mosquito   897 FEARVKDQMQAFLEGVSSLVPLHLLKIFDENELELLMCGIQSIDVNDWKKNTMYKGDYYANHAVV 961

  Fly  5056 QWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFN 5120
            ||||||:.||:...|::.||||||||:||:.||..|.|.||.|.|.|.:.. :.:..|.||||||
Mosquito   962 QWFWRAVLSFNNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQLFTIEKWG-TVNNFPRAHTCFN 1025

  Fly  5121 QLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            :||||.|:||.:|:..|:.|| |.|:||
Mosquito  1026 RLDLPPYESYAQLKEKLISAI-EGSQGF 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	168/358 (47%)
Nedd4	XP_061505717.1	None