Protein Alignment HUWE1 and Hecw

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_061498351.1
• Gene: Hecw / 1272391
• VectorBaseID: AGAMI1_002409
• Length: 1286
• Species: Anopheles gambiae
• Alignment Length: 1698
• Identity: 360/1698 - (21%)
• Similarity: 567/1698 - (33%)
• Gaps: 557/1698 - (32%)

  Fly  3594 SNQPEPTPESSESTSPNPQA--PSAEPTP-LEPGAAVDA-SVGAQTPATTEEAASTAGASGTTAT 3654
            |.:.|...:..|:..|.|.|  |..||.| .:|.:..|. ::|.|:..:..|
Mosquito     2 SCEREGAGDEPEAACPRPTANPPGKEPEPEADPESEQDGLAIGGQSHQSDGE------------- 53

  Fly  3655 ITDMSPEVRAALGDLEVPEGVDPSFLAALPSEMREEVIQEHLRMQRIRQRAQQNAIQIAHDSLVE 3719
              |...:      |.|..|..|            ||..:|......:|...||:.....::..::
Mosquito    54 --DEDDD------DEEDDEEDD------------EEEEEEEEEPPELRVAVQQDFPPTPYEECLD 98

  Fly  3720 VNPEFLAALPLNIQSEVLMQQRIEQQRQAAQTANPE---DPVDTAAFFQNLPENLRQAILTDMEE 3781
            :....|...|.. :::....:|.|:..:..:..:.|   |.||.:| ..||......||   :..
Mosquito    99 LKMFELRTEPAG-EAQEPTPERSEEDEEGEEEGSGEVEADSVDNSA-EDNLQPEPGPAI---VPS 158

  Fly  3782 SQIASLPPELAAEAQFLRRDWESRNGAR------MDAHPPSNALSRFQTTLQSLDDTRWHSS--- 3837
            ....|||   ||.:...|:..:..|||.      .|..|..|...: :.....|...|...|
Mosquito   159 PSATSLP---AATSGVRRKSEQPANGAPEPPDVVPDEEPTPNGTKK-KVRPNRLSPERAGCSRKK 219

  Fly  3838 -IWYDASGNAQPQHHQHTTIVHQHPHAHHAPNMGKPLALLMMEDENILLDPDSLATLLLFLFVED 3901
             .|.:.:...    ..|..:....|...|.|:.|:|........:....|         .:.:::
Mosquito   220 QFWIEGTAGT----GGHRPLERSWPPKAHRPSPGRPFPGATTPGDGFSFD---------IIDMDE 271

  Fly  3902 QKVNSMRLHRVIRNLCHHEPTRDWIISALISIIQKTNEDNANFGAGQAGGKPEWLKLRVDAAFGY 3966
            |:....:.||      |||...                       |..||:.     ..||
Mosquito   272 QQQQQQQQHR------HHEEVE-----------------------GAVGGQE-----MPDA---- 298

  Fly  3967 KSNIFLINRLYEGSARSISINPQAAQMIVRNCLDLLFVLAKHYPSSFVPFNRDVKARRILSAVFG 4031
                       ||       ||...|.                    .|..|:.:..|     .|
Mosquito   299 -----------EG-------NPVGGQS--------------------TPRRRNRRPDR-----NG 320

  Fly  4032 MPSPTAG-SGGGAGSGSAASGGLTGYDDVPPGGTLDFRSRFCRYQVVNRLRSIFDDHP---APKP 4092
            ...|..| |....|:|......:.|                         ||..|:|.   |.:|
Mosquito   321 NDEPDTGESARATGAGKQPLRKMVG-------------------------RSGADEHEVAGAVRP 360

  Fly  4093 SVPLDEAPSTSKAAAAKA-----------AATAKVSTAGSQNKHSVPYQTNAKNFWDVVLNIDQQ 4146
            ..||...||..:....:.           .|.|.|.||.|
Mosquito   361 HRPLARTPSNGREPRCREYGPIRPLPVDYTADASVHTARS------------------------- 400

  Fly  4147 TQVRLANVAQFPLTSQPAWEWQPNTADFLSFSESPFGQLLEMLPYKVICRSPHLTDMLVKLLASL 4211
                            ||.|  |.|....| .:.|.|:
Mosquito   401 ----------------PASE--PGTPGDRS-PDQPQGR--------------------------- 419

  Fly  4212 STELPKEEELLPL------SDQMPPLVPIGPVQ--RAGAAAAAAHP----------------PPP 4252
              ..|:..:|..:      |:.:.|..|....:  |||.|.:||.|                .|.
Mosquito   420 --SAPQPRQLTRVGGGRAGSELVCPPTPTHHARRNRAGPAPSAAPPEHGFGPPELRLHRQQTAPD 482

  Fly  4253 QPPAENTATATEIGDGLAANIEEQASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIY 4317
            |||        |.|.|       :..|..|.||.     ||....:|  |:.||..|.: .|.|.
Mosquito   483 QPP--------EGGFG-------EQEPPPGEPAE-----GATVRHVP--SMRLPSIPER-TRAIL 524

  Fly  4318 SKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYLTAAILGLAEEVRQAIQ 4382
            ::....|....|......|....:|:..:     |...|....:.    |:|:| |.:..||.:.
Mosquito   525 AEPDEPLPPAWEARMDSHGRIFYIDHATR-----TTSWQRPGPLG----TSAVL-LPDPHRQQLD 579

  Fly  4383 MLLNEIRMYNIHQ---------------GGAGTTSQAASTSGAAAATASYVPTVSGASLLPNL-- 4430
            .....||. .|::               |...|.|:::||..:..|    :|:.:| |..|.|
Mosquito   580 RRYASIRR-TIYEHLRPENGAAPSTSSTGPVATRSRSSSTGRSTVA----LPSTAG-SFHPALLM 638

  Fly  4431 --------AVHEG-----IMQDRFTAEHVIISAPKN--------------------AKPTCELQL 4462
                    .:|..     :.......:|::....::                    |:|..|  |
Mosquito   639 LCRSDFYSMLHTNGDAIQLYNRNAALKHMVSRVRRDPGCFGRYQHNRDLVALVNCFAQPAQE--L 701

  Fly  4463 PSMKKLMSNSSAQPYFL-----RTLKIFMQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGD- 4521
            ||..:...:.|.:.:|:     ||..|                            |..:..||.
Mosquito   702 PSGWETKLDQSGKQFFIDHVNRRTSFI----------------------------DPRLPTEGPR 738

  Fly  4522 --------GGA------SGGSSSDMAPGSASTISPP-PPMETNQIAQDGDDD--EEDDDEARSF- 4568
                    |.|      :.|...|..|     |.|| ||...:::|.....:  ...:|:..:|
Mosquito   739 ARHHRPPVGPAALLLPPASGPFPDERP-----IPPPRPPGTLSRLAHVSSPEIPVAYNDKVVAFL 798

  Fly  4569 --PGV-----GNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAF 4626
              |.:     ..|..|:.|::.:..::.|..         |...||:....:..:.:|....|..
Mosquito   799 RQPNILEILRERHGAAACSRNLREKINAIRV---------EGTTALDRYSHDLELTILLSLFEDE 854

  Fly  4627 FLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSA 4691
            .:.:...|..|        |...|    .:||.|..|||                     .|..|
Mosquito   855 VMTYVPPRARS--------PPEPG----TSAGYGPCGGL---------------------VPGGA 886

  Fly  4692 SFDDEPRMQDASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSD 4756
                                                                   |:....|:..
Mosquito   887 -------------------------------------------------------LKPGGRHVQR 896

  Fly  4757 GPFAVLVDHTRILDFDVKRKYFQTELERLDEGIRREEHTVSVRRVTVFEDSF-RVLYRLGPEEWK 4820
            .|..        .||:.|.:.|..:||....|....:..:.|||..:.||:| |::.....:..:
Mosquito   897 APMR--------RDFEAKLRTFYRKLESKGYGQGPHKLRLEVRRAHLVEDAFERIMAASRRDLQR 953

  Fly  4821 NRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNH-LSYF 4884
            .|..||::.|:|.|.||..||::.::||::|:|...:|..|..|..|..|.|....:.:. |.::
Mosquito   954 CRLNIVWDTEDGLDYGGPSREFFYLLSRQLFSPYRNMFEYSANDIYTVQIAPERPTDRDDILEWY 1018

  Fly  4885 KFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLG-YE 4948
            :|.|||:..|:....||:.:|||.|||.:|...|..:|:||.|..|::.|.::..|::...| ..
Mosquito  1019 RFAGRVLGLALVHQYLLDAFFTRPFYKALLRLPVSLSDLESLDSSFHQSLLWIRDNNMDNCGELG 1083

  Fly  4949 LTFS-TEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIP 5012
            |.|: ||.:..|.:...:||||||:..|:|.||.:|:..:.:.::...:.:|.:..:.||.:::.
Mosquito  1084 LNFTVTEERSDGTSIDIELKPNGRNITVSERNKRDYLDRIIKWRLERGVLEQTEWLVRGFNEVVD 1148

  Fly  5013 KHLISIFNEQELELLISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQF 5076
            ..|:::|:..||||:|||..:||:.|.:|||||. .|......|.|||..:.......|.:.|||
Mosquito  1149 HRLVAVFDASELELVISGTVEIDVHDWRANTEYRGGYHDTHHVIMWFWAVIERMSNEQRLRLLQF 1213

  Fly  5077 VTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAI 5141
            |||||.:|..||..|.|.||:::|.|.:..:: :.||.:|||||:||||.|.:.|.|...|:.|:
Mosquito  1214 VTGTSSIPHDGFAGLRGSNGLRRFCIEKWGKA-NALPRSHTCFNRLDLPPYPTPDVLYEKLVLAV 1277

  Fly  5142 HECSEGFG 5149
            .| :..||
Mosquito  1278 EE-TNTFG 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521	18/81 (22%)
		UBM	3670..3700	CDD:464159	6/29 (21%)
		UBM	3719..3746	CDD:464159	4/26 (15%)
		HECTc	4796..5149	CDD:238033	127/357 (36%)
Hecw	XP_061498351.1	None