Protein Alignment HUWE1 and LOC1272379

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_061500391.1
• Gene: LOC1272379 / 1272379
• VectorBaseID: AGAMI1_003900
• Length: 1025
• Species: Anopheles gambiae
• Alignment Length: 1163
• Identity: 302/1163 - (25%)
• Similarity: 461/1163 - (39%)
• Gaps: 325/1163 - (27%)

  Fly  4069 SRFCRYQVVNRLRSIFDDHPAPKPSVPLDEAPSTSKAAAAKAAATAKVSTAGS-QNKHS-VPYQT 4131
            :|..|...:..:....|..|..:|.|   |.|..|.....:.:..|:.:..|. |..|: :..|.
Mosquito   101 NRLTRDDFLGMVELSLDQLPKERPGV---EIPIRSYPLRPRRSVRARSNVRGELQLYHAFIVDQD 162

  Fly  4132 NAKNFWDV-----VLNIDQQTQVRLANVAQFPLTSQPAWE--------------------WQ-PN 4170
            :.:..|::     |.::....:...:|.|.|.|..  .||                    |: |.
Mosquito   163 SNETDWEMVDSNPVPSVASTPRSSTSNAAAFELPQ--GWEERQDANGRTYYVNHVARSTQWERPT 225

  Fly  4171 TADFLSFSESPFGQLLEMLPYKVICRSPHL---------TDMLVKLLASLSTELPKEEELLPLSD 4226
            .....:.:||......:        |..|:         |..:...||:|.....:...|:..|:
Mosquito   226 AVPMEAIAESDMDVAFQ--------RRVHISVDDSATSDTGSVGSDLAALQLNTSRSNSLVSASN 282

  Fly  4227 --QMPPLVPIGP---------VQRAGAA-AAAAH---PPPPQPPAENTATATEIGDGLAANIEEQ 4276
              ......|.|.         |.|:||| |.:||   ..||:.||....::|            :
Mosquito   283 GSLASSARPDGSAEKESTHTVVLRSGAAPAQSAHRHLSTPPRLPAALVRSST------------R 335

  Fly  4277 ASPASGNPASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQ-CGTTEG 4340
            |.|..|..|:..:.:.:..::..|:..|....|.:.                |.||.: ..||..
Mosquito   336 AVPIPGRAAAALNRSRSAVSRWTTVGAAGQARPGRH----------------EQLTEEPAQTTAE 384

  Fly  4341 LDNVAKLIVNLTQC---------SQASSAIFIQYLTAAILGLAEEVRQAIQMLLNEIRMYNIHQG 4396
            .:|.....|.|...         |.:.|:|      .:...|..:.|.||.....::    :..|
Mosquito   385 QENGENGGVQLRSSAHLADGGRRSSSRSSI------GSDSSLRAQQRAAIDAADEDM----VDGG 439

  Fly  4397 GAGTTSQAASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQ 4461
            |.|   |....||::.:::|     |.||        ..:..||              :|:
Mosquito   440 GVG---QTVVRSGSSHSSSS-----SSAS--------SNMNGDR--------------RPS---- 470

  Fly  4462 LPSMKKLMSNSSAQPYFLRTLKIFMQVRDMYEAQNGLSTGGGVACGA--GDNDDDIIDIEGDGGA 4524
                    ::....|:.             ::..|..:.||....||  |.|..:..|...|..:
Mosquito   471 --------TSGGTHPHH-------------HQHHNNNNNGGTFGTGATHGSNSINNNDTSDDRSS 514

  Fly  4525 SGGSSSDMAPGSASTISPPPPMETNQIAQDGDDDEEDDDEARSFPGVGNHAVASASKSTKPTLSQ 4589
            :..|:|:                             ::|.:.|.|..|..|.:
Mosquito   515 TRSSTSN-----------------------------ENDSSGSSPSTGGGAGS------------ 538

  Fly  4590 ILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGA--SKKSGR-SFMPNAAGF 4651
             :.|...|:                  :.|.|....||:.|...:.:  ..::|| |.||.:.|
Mosquito   539 -MTLPAGWS------------------MQLAPNGRVFFIDHNERKTSWVDPRTGRASPMPTSQG- 583

  Fly  4652 GLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANTPSSASFDDEPRMQDASTNTPLVTNPSTST 4716
                                                  ||:..|..|.:|.....|
Mosquito   584 --------------------------------------SAALSDVRRPEDGLAPLP--------- 601

  Fly  4717 AMSAHEAQLRQDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAV------LVDHTRILDFDVKR 4775
              ...|.::..|.:.|  |.: |.|        ..|...|...::      .|.::|    |.||
Mosquito   602 --EGWEERVHSDGRIF--FID-HNT--------RTTQWEDPRLSIPNIAGQAVPYSR----DYKR 649

  Fly  4776 KYFQTELERLDEGIRREEHT-----VSVRRVTVFEDSFRVL---YRLGPEEWKNRFYIVFEDEEG 4832
            ||     |.|...:|:.::.     :.|||.::.|||:|::   .||  :..|.:.:|.||.|.|
Mosquito   650 KY-----EYLKTQLRKPQNVPNKIEIKVRRASIMEDSYRIINSVTRL--DLLKTKLWIEFEGEAG 707

  Fly  4833 QDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSH-ANPNHLSYFKFVGRVIAKAVH 4896
            .|.|||.|||:.::|:|:|||.|.||..|..|..|..|||.|. .|.:||.||:|:||:...||:
Mosquito   708 LDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINPYSELCNEDHLLYFRFIGRIAGMAVY 772

  Fly  4897 DNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVT 4961
            ..|||:.:|.|.|||.:|.|.:...|||:.|.|:|..|.::.:||.|.|  .|||..:.:.||.|
Mosquito   773 HGKLLDAFFIRPFYKMMLQKPIDLKDMEAVDTEYYNSLVWIKENDPSEL--MLTFCVDEETFGQT 835

  Fly  4962 QIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELEL 5026
            ...:|.|||....||.|||.||::||.|.:....::.|:.|||:||..::|.:|:.||:|.||||
Mosquito   836 TQHELLPNGAAIDVTNENKDEYIRLVIQWRFVSRVQVQMQAFLDGFGSLVPLNLLKIFDEHELEL 900

  Fly  5027 LISGLPDIDIEDLKANTEYH-KYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGS 5090
            |:.|:.:||:.|.|.||.|. .|......|||||||:.||....||:.||||||||:||:.||..
Mosquito   901 LMCGIQNIDLRDWKRNTLYKGDYYPNHVVIQWFWRAVLSFSNEMRARLLQFVTGTSRVPMNGFKE 965

  Fly  5091 LEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGF 5148
            |.|.||.|.|.|.:.. :.:..|.||||||:||||.|:||.:|:..|::|: |.|:||
Mosquito   966 LYGSNGPQMFTIEKWG-TPENYPRAHTCFNRLDLPPYESYQQLKDRLIQAV-EGSQGF 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	164/358 (46%)
LOC1272379	XP_061500391.1	None