Protein Alignment HUWE1 and Smurf

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: XP_061510268.1
• Gene: Smurf / 1270684
• VectorBaseID: AGAMI1_012422
• Length: 1244
• Species: Anopheles gambiae
• Alignment Length: 1021
• Identity: 277/1021 - (27%)
• Similarity: 401/1021 - (39%)
• Gaps: 292/1021 - (28%)

  Fly  4254 PPAENTATATEIGDGLAANIEEQ----ASPASGN------PASGDSNAGAKRTQLPTLSVALPVT 4308
            |.:.||:..:||...:.:..::|    .||.|||      ..||.:||      :.|||:..|
Mosquito   391 PSSSNTSPLSEINSPITSPKQQQQQQDVSPRSGNGGREPQQVSGMTNA------IGTLSIDAP-- 447

  Fly  4309 PSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLT--------QCSQASSAIFIQY 4365
               |.|.                    ||            |.|        ||     .:.:..
Mosquito   448 ---PARS--------------------GT------------NATSGGGGGGQQC-----VVMVNG 472

  Fly  4366 LTAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATA-SYVPT--------- 4420
            ..|.:...:....|              ||...|...|.|....||..|. ||:|.
Mosquito   473 SGAGVTNYSSPNHQ--------------HQRSTGDAGQPAGHPAAAKPTVPSYLPLSTSNGTTNG 523

  Fly  4421 VSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPYFLRTLKIF 4485
            .:|.:...|.:.|.|:      :.|                        |:|::.|
Mosquito   524 TAGTTGSSNSSPHNGV------SNH------------------------SSSASAP--------- 549

  Fly  4486 MQVRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGDGGASGGSSSDMA--------------PGS 4536
                   :...|...|||...|.|............||.|||.....|              ||.
Mosquito   550 -------DTVGGGGGGGGGGGGGGGRSQHHHGTPTTGGESGGHREGSASRYHRTRSGRHAEEPGR 607

  Fly  4537 AST--------------ISPPP--------------------PMETNQ----------------- 4550
            ..|              ::|||                    .:.|.|
Mosquito   608 RRTSRDRPPRPLMGGGSMAPPPNARPALVPFIRPAVDLPHGYEIRTTQQGQVYFYHIPTKQSTWH 672

  Fly  4551 ---IAQDGDDDEEDDDEARSFP-GVGNHAVAS-----------ASKSTKPTLSQILCLDVLWNTL 4600
               |.:|.|......:.....| |......||           .::.|.|.::..:
Mosquito   673 DPRIPRDFDTQNLTTETLGPLPHGWEQRKTASGRVYFVDHNNRTTQFTDPRINMHI--------- 728

  Fly  4601 SECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGL 4665
                  |:..:.:.:|......|.|     |:..|....:|.|..| .:|.|.:...|.||.|..
Mosquito   729 ------LQMIRRQNSVAAAAAAVAA-----ATGGGGVATNGCSSSP-LSGAGPQVPNGTGAAGSG 781

  Fly  4666 G---AAAPSAQEYSPFMDDVSSANTPSSASFDDEP-RMQDASTNTPLVTNPSTSTAMSAHEAQLR 4726
            .   |||..|:..:|..:.|||            | |.........::..|...:|::|
Mosquito   782 SSRYAAAALAEAVNPIANGVSS------------PWRACRCVVCIDMLHGPRGGSAIAA------ 828

  Fly  4727 QDRQKFLQFAEKHRTVLNQILRQSPTHLSDGPFAVLVDHTRIL-----DFDVKRKYFQTELERLD 4786
                     .....|..|.:....| .|..|    |:|...:|     |...|.:..:.||:.|.
Mosquito   829 ---------TGSSTTTTNHVTNNIP-DLPQG----LMDSADLLPKYRSDLVGKIRALRQELQLLQ 879

  Fly  4787 EGIRREEH-TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREI 4850
            .   :..| .:.|.|..:||:|:|::.::.|::.:.|..:.|:.|||.|.||:.|||..::|.|:
Mosquito   880 P---QSGHCRLEVSRNEIFEESYRLIMKMRPKDMRKRLMVKFKGEEGLDYGGVAREWLYLLSHEM 941

  Fly  4851 FNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILG 4915
            .||.|.||..|..|..:..|||.|..||.|||||.||||::..||..|.:|:..||..|||.:|.
Mosquito   942 LNPQYGLFQYSRDDHYSLQINPDSSINPEHLSYFHFVGRILGIAVFHNHVLDGGFTLPFYKQLLN 1006

  Fly  4916 KQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENK 4980
            |.:..:|:|..|.:.::.|.::::|:|:.: .:.|||.|...|||.::.:|||||...||||:||
Mosquito  1007 KPITLSDIEDVDPDLHRSLTWILENNITGI-IDSTFSVENNSFGVLKVHELKPNGASIAVTEDNK 1070

  Fly  4981 FEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEY 5045
            .|||:|....:....|.||..|..:||.::|..||:..|:|:||||||||:..||:.|.||||..
Mosquito  1071 REYVKLYVNYRFMRGIEQQFLALSKGFGELILSHLLRPFDERELELLISGISKIDVNDWKANTRL 1135

  Fly  5046 HKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFGSLEGMNGI---QKFQIH-RDD 5106
            .:.|:.:.||.|||:.:.|:....||:.||||||:.:||||||.:|:|..|.   :.|.|| ..|
Mosquito  1136 KQCTADTPQIVWFWQIVESYSPEMRAQLLQFVTGSCRVPLQGFRALQGSTGAVGPRLFTIHLTAD 1200

  Fly  5107 RSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHE-CSEGFGFA 5151
            .....||.||||||:||||||.||..:...|.:|:.| |    |||
Mosquito  1201 VPLQNLPKAHTCFNRLDLPMYDSYQLMYDKLTQAVEETC----GFA 1242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	155/357 (43%)
Smurf	XP_061510268.1	None