Protein Alignment HUWE1 and WWP2

DIOPT Version :10

• Sequence 1: NP_001285288.1
• Gene: HUWE1 / 32510
• FlyBaseID: FBgn0030674
• Length: 5151
• Species: Drosophila melanogaster
• Sequence 2: NP_008945.2
• Gene: WWP2 / 11060
• HGNCID: 16804
• Length: 870
• Species: Homo sapiens
• Alignment Length: 993
• Identity: 269/993 - (27%)
• Similarity: 409/993 - (41%)
• Gaps: 255/993 - (25%)

  Fly  4285 ASGDSNAGAKRTQLPTLSVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIV 4349
            ::..|.||          ||||              |.:.||.::|::            ||..|
Human     3 SASSSRAG----------VALP--------------FEKSQLTLKVVS------------AKPKV 31

  Fly  4350 NLTQCSQASSAIFIQYLTAAILGLAEEVRQ------AIQMLLNEIRMYNIHQGGAGTTSQA---- 4404
            :..|....|      |:..|:.||..|.::      :.::|.|||.:.|:       |:|:
Human    32 HNRQPRINS------YVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNV-------TAQSHLDL 83

  Fly  4405 ---------ASTSGAAAATASYVPTVSGASLLPNLAVHEGIMQDRFTAEHVIISAPKNAKPTCEL 4460
                     ....|.|:...|.|...:|..:                         :|.:.|..|
Human    84 KVWSCHTLRNELLGTASVNLSNVLKNNGGKM-------------------------ENMQLTLNL 123

  Fly  4461 QLPSMKKLMSNSSAQPYFLRTLKIFMQ--VRDMYEAQNGLSTGGGVACGAGDNDDDIIDIEGD-- 4521
            |..:...::|...        |.||:.  ..|:....||.:...|....:.|:....:..|..
Human   124 QTENKGSVVSGGE--------LTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQ 180

  Fly  4522 -------GGAS-----GGSSS-------DMAPGSASTISPPPPMETNQIAQDGDDDEE----DDD 4563
                   ||.|     .|:|:       :.:||:.|....|.....:....:|..::|    .|.
Human   181 PPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDP 245

  Fly  4564 EARSFPGVGNHAVASASKSTKPTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFL 4628
            |..|..||.:...|..|.:..|            ||.|....|.....:|       |:.
Human   246 EEPSVVGVTSPPAAPLSVTPNP------------NTTSLPAPATPAEGEE-------PST----- 286

  Fly  4629 IHASHRGASKKSGRSFMPNAAGFGLRAAAGAGAIGGLGAAAPSAQEYSPFMDDVSSANT-----P 4688
                       ||...:|.||     .|..|...|......|:.:.|  ::|..:...|     |
Human   287 -----------SGTQQLPAAA-----QAPDALPAGWEQRELPNGRVY--YVDHNTKTTTWERPLP 333

  Fly  4689 SSASFDDEPRMQ----DASTNTPLVTNPS-------------------------------TSTAM 4718
            .......:||.:    |.:|.|.....|:                               :|:|.
Human   334 PGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSAS 398

  Fly  4719 SAHEA--------QLRQDRQKFLQFAEKHRTV-----LNQILRQSPT--------HLSDGPFAVL 4762
            :.|:.        :.|||..:........||.     ..|.:.|.|.        :.|:| ....
Human   399 TDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEG-VRYF 462

  Fly  4763 VDH-TRILDFDVKRKYFQTELER-----LDEGIRREEH---------------TVSVRRVTVFED 4806
            ||| ||...|...|..|::..::     .|...|.:.|               .:||.|.|:|||
Human   463 VDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFED 527

  Fly  4807 SFRVLYRLGPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMIN 4871
            ||:.:..:.|.:.:.|.||:...|||.|.||:.|||:.::|.|:.||||.||..:..:.....||
Human   528 SFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQIN 592

  Fly  4872 PSSHANPNHLSYFKFVGRVIAKAVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDY 4936
            |:|..||:||:||:|:||.||.|::..|.::..||..|||.:|.|:....|:||.|.|||..:.:
Human   593 PASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVW 657

  Fly  4937 LMKNDISTLGYELTFSTEVQEFGVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLD 5001
            :.:|::...|.||.|..:::..|.....:||..|....||||||.||:.|:...:.:..:.:|..
Human   658 IKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTK 722

  Fly  5002 AFLEGFYDIIPKHLISIFNEQELELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFD 5066
            |||:||.::.|...:..|:|:||||::.|:.:||:.|.:.:|.|..||..|.||||||:.::..|
Human   723 AFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMD 787

  Fly  5067 QADRAKFLQFVTGTSKVPLQGFGSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYD 5131
            ...|.:.|||||||.::|:.||..|.|.||.|||.|.:..:.| .||.:|||||:||||.||||:
Human   788 NEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKET-WLPRSHTCFNRLDLPPYKSYE 851

  Fly  5132 KLRSCLLKAIHECSEGFG 5149
            :||..||.||.| :||||
Human   852 QLREKLLYAIEE-TEGFG 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	NP_001285288.1	DUF908	90..326	CDD:428721
		DUF913	621..989	CDD:461803
		UBA_like_SF	1467..1506	CDD:473871
		WWE	1756..1828	CDD:128922
		DUF5585	3288..3672	CDD:465521
		UBM	3670..3700	CDD:464159
		UBM	3719..3746	CDD:464159
		HECTc	4796..5149	CDD:238033	152/352 (43%)
WWP2	NP_008945.2	C2_E3_ubiquitin_ligase	17..142	CDD:175988	33/182 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..299		35/187 (19%)
		PHA03247	<164..343	CDD:223021	40/220 (18%)
		WW	302..331	CDD:459800	5/30 (17%)
		WW	332..361	CDD:459800	6/28 (21%)
		WW	407..435	CDD:459800	5/27 (19%)
		WW	447..477	CDD:238122	8/30 (27%)
		HECTc	516..868	CDD:238033	152/353 (43%)