DRSC/TRiP Functional Genomics Resources

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Protein Alignment HUWE1 and itcha

DIOPT Version :10

Sequence 1:NP_001285288.1 Gene:HUWE1 / 32510 FlyBaseID:FBgn0030674 Length:5151 Species:Drosophila melanogaster
Sequence 2:NP_001274024.1 Gene:itcha / 100331274 ZFINID:ZDB-GENE-120919-4 Length:851 Species:Danio rerio


Alignment Length:906 Identity:261/906 - (28%)
Similarity:405/906 - (44%) Gaps:167/906 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  4302 SVALPVTPSKPRRKIYSKNFSQLQLVIEVLTHQCGTTEGLDNVAKLIVNLTQCSQASSAIFIQYL 4366
            |:.:.|||       :||      |:..|.:||....:.|..||.|.|:.|             |
Zfish    53 SLTVIVTP-------FSK------LIFRVWSHQTLKADILLGVASLEVSET-------------L 91

  Fly  4367 TAAILGLAEEVRQAIQMLLNEIRMYNIHQGGAGTTSQAASTSGAAAATASYVPTVSGASLLPNLA 4431
            .|..:.:.|.| |.:|:..:..|...:.................|:....:...|:|.|.|...|
Zfish    92 KANNMKICEVV-QTLQLSSDRGRSEQVGDLSLCLDGLQVDAETFASEEQKHNAVVNGESRLNGDA 155

  Fly  4432 VHEGIMQDRFTAEHVIISAPKNAKPTCELQLPSMKKLMSNSSAQPY--FLRTLKIFMQVR----- 4489
            :..   :|...:..:...||          ||:...:.|::||.|.  .||..:.....|     
Zfish   156 IRS---RDSSPSSDITDDAP----------LPNGHAVGSSASASPSTGALRAPRPLRPQRPPPAS 207

  Fly  4490 -DMYEAQNGLSTGGGVACGAGDNDDDI---IDIEGD---GGASGGSSSDMAPGSASTISPPPPME 4547
             ..:.:....|||.....|:.....::   :.:.|:   .|:|.||.|:.|| .||...|..|..
Zfish   208 PHKHTSSTASSTGSTPTHGSSAPSPEMSPRVCVNGETESQGSSSGSGSNQAP-RASPTPPRAPAI 271

  Fly  4548 TNQIAQDGDDDEEDDD-------------------------EARSFPGVGNHAVASASKST---K 4584
            ||.....|.:...|.:                         |.|..|....:.|...:::|   :
Zfish   272 TNGPLPPGWEQRADQNGRVYYVDHIEKRTTWERPEPLPPGWERRLDPMGRVYYVDHINRTTTWQR 336

  Fly  4585 PTLSQILCLDVLWNTLSECLVALEESKDEFAVLVLQPTVEAFFLIHASHRGASKKSGRSFMPNAA 4649
            |||..:...:...|..|:.                              :||.::..:.|:    
Zfish   337 PTLESVRNYEEWQNQRSQL------------------------------QGAMQRFNQRFI---- 367

  Fly  4650 GFGLRAAAGAGAIGGLGAAAPSA-QEYSPF------MDDVSSANT-------PSSASFDDEPRMQ 4700
             :||:.           ..||:| :|:.|.      .:..:.:|.       |:.::..::||.|
Zfish   368 -YGLQE-----------QLAPTANKEFDPLGPLPSGWEKRTDSNRRMYFVHHPTRSTQWEDPRTQ 420

  Fly  4701 DASTNTPLVTNPSTSTAMSAHEAQLRQDRQKFLQFAEKHRTVLNQI-LRQSPTHLSDGPFAVLVD 4764
            ......||         ....|.:...|...:  |.:.:|.....| .|...:.|.:||     .
Zfish   421 GLLNEKPL---------PEGWEMRFTVDGIPY--FVDHNRRTTTYIDPRTGKSSLENGP-----Q 469

  Fly  4765 HTRILDFDVKRKYFQTELERLDEGIRREEH-TVSVRRVTVFEDSFRVLYRLGPEEWKNRFYIVFE 4828
            .|.:.||..|..||:...::|.    ..:| .:.|.|.|:|||||:.:....|::.:.|.:|:|.
Zfish   470 ITYVRDFKAKVHYFRFWCQQLS----MPQHIKIHVSRKTLFEDSFQQIMGCHPQDLRRRLWIIFP 530

  Fly  4829 DEEGQDAGGLLREWYVIISREIFNPMYALFCVSPGDRVTYMINPSSHANPNHLSYFKFVGRVIAK 4893
            .|||.|.||:.|||:.::|.|:.||||.||..:..|.....|||:|..||:||.||||:||.||.
Zfish   531 GEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSINPDHLKYFKFIGRFIAM 595

  Fly  4894 AVHDNKLLECYFTRSFYKHILGKQVKHTDMESQDYEFYKGLDYLMKNDISTLGYELTFSTEVQEF 4958
            |:...|.::..|:..|||.||.|.:...|:||.|.|||..|.::..|:|...|.|:.||.:.:..
Zfish   596 ALFHGKFIDTGFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKDNNIEECGLEMFFSVDKEIL 660

  Fly  4959 GVTQIRDLKPNGRDTAVTEENKFEYVQLVCQLKMSGSIRQQLDAFLEGFYDIIPKHLISIFNEQE 5023
            |.....:|||:|.:..||||||.||::||.:.::|..:.:|..||||||.|::|:..:..|:.:|
Zfish   661 GEVTTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFLEGFNDVLPQQYLQYFDAKE 725

  Fly  5024 LELLISGLPDIDIEDLKANTEYHKYTSKSAQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGF 5088
            ||:::.|:.:||:.|.:.|:.|..|...|.||.|||:.::..|...|.:.|||||||.::|:.||
Zfish   726 LEVMLCGMQEIDLGDWQRNSIYRHYARSSKQIVWFWQFVKEMDNEKRMRLLQFVTGTCRLPVGGF 790

  Fly  5089 GSLEGMNGIQKFQIHRDDRSTDRLPCAHTCFNQLDLPMYKSYDKLRSCLLKAIHECSEGFG 5149
            ..|.|.||.|||.|.:..:. :.||.:|||||:||||.||||::|:..||.||.| :||||
Zfish   791 ADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEE-TEGFG 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HUWE1NP_001285288.1 DUF908 90..326 CDD:428721
DUF913 621..989 CDD:461803
UBA_like_SF 1467..1506 CDD:473871
WWE 1756..1828 CDD:128922
DUF5585 3288..3672 CDD:465521
UBM 3670..3700 CDD:464159
UBM 3719..3746 CDD:464159
HECTc 4796..5149 CDD:238033 154/352 (44%)
itchaNP_001274024.1 C2_E3_ubiquitin_ligase 2..125 CDD:175988 23/98 (23%)
WW 276..305 CDD:459800 2/28 (7%)
HUL4 <307..851 CDD:227354 200/611 (33%)
Blue background indicates that the domain is not in the aligned region.

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