DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hap40 and F8A3

DIOPT Version :10

Sequence 1:NP_573056.1 Gene:Hap40 / 32507 FlyBaseID:FBgn0030671 Length:345 Species:Drosophila melanogaster
Sequence 2:NP_001007525.1 Gene:F8A3 / 474384 HGNCID:31850 Length:371 Species:Homo sapiens


Alignment Length:397 Identity:90/397 - (22%)
Similarity:125/397 - (31%) Gaps:154/397 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LGGGGSSSGAPSTAPGHEHHQLEQYQYPKNLIEQYLRASSKIKKFERAGFFKRF--APSVVDVQA 71
            |||||:       .||.|         ..:.:.:|...|:|:|        |||  .|:|.:...
Human     8 LGGGGA-------GPGPE---------AGDFLARYRLVSNKLK--------KRFLRKPNVAEAGE 48

  Fly    72 DFQRLAYSFEESGIQQYAAMCHIGYAKCESYGGAPQRESEAYLRAARSFL-------------AA 123
            .|.:|...........|||.|.:..|:|:........|:.|...|||.||             ||
Human    49 QFGQLGRELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQERDARQRLVCPAA 113

  Fly   124 HNE-----------SGRLHLRTRHSGFREGAVHCYHRAADRAVDGCVFKAAILRELKQ------- 170
            :.|           :.||||.....            ||..|:  |:..||.||:|.|       
Human   114 YGEPLQAAASALGAAVRLHLELGQP------------AAAAAL--CLELAAALRDLGQPAAAAGH 164

  Fly   171 ----LQRQL----------------------DSTSSFASPT--------HQIHDLE--------- 192
                .|.||                      |.|.:.|..|        |..|.::         
Human   165 FQRAAQLQLPQLPLAALQALGEAASCQLLARDYTGALAVFTRMQRLAREHGSHPVQSLPPPPPPA 229

  Fly   193 --------------ISAETSGQRGDFRSALQHYDDIVDNVYERRGARMYGELLRRVEVLRLLLLV 243
                          :....||......:||..:.|:                |.|.||.|:|||:
Human   230 PQPGPGATPALPAALLPPNSGSAAPSPAALGAFSDV----------------LVRCEVSRVLLLL 278

  Fly   244 HLNLPPARQSPAHIKLIEYYYNLAQFESLPCSADDGGSAERPGAFVPEQQQYALAEITCAWVERK 308
            .|..|||:..|.|.:.:|.|         ...|.|....|..|. :||:....|..:..|..|:.
Human   279 LLQPPPAKLLPEHAQTLEKY---------SWEAFDSHGQESSGQ-LPEELFLLLQSLVMATHEKD 333

  Fly   309 MCDLKHL 315
            ...:|.|
Human   334 TEAIKSL 340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hap40NP_573056.1 None
F8A3NP_001007525.1 Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q00558 34..36 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..250 2/36 (6%)

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