Protein Alignment Alp11 and ALPI

DIOPT Version :10

• Sequence 1: NP_573047.1
• Gene: Alp11 / 32496
• FlyBaseID: FBgn0030661
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 191/499 - (38%)
• Similarity: 265/499 - (53%)
• Gaps: 57/499 - (11%)

  Fly    20 ILALSVPMVEQVQPADELLSSHWLRQAQSQLRERLARTKDSIADVRQAKNVVMLLGDGLSITTLT 84
            :|.|.:.:...|.||:|...:.|.|||...|  ..|:....|..|  |||:::.|||||.:.|:|
Human     9 LLGLRLQLSLGVIPAEEENPAFWNRQAAEAL--DAAKKLQPIQKV--AKNLILFLGDGLGVPTVT 69

  Fly    85 AARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVKTHSGTVGQSGS 149
            |.||||||:.|..|.:..||:::||:..|||||.:|.|.||||.|||||..|||.:..|:|.|.:
Human    70 ATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAA 134

  Fly   150 ----------GERVDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRRG------------E 192
                      |..|.||:..|::|||:.|||||||:..|||||.|||...|.            :
Human   135 ARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQ 199

  Fly   193 E--LEIARQLVEEEPGRNLNVILGGG------LGKFADE----------RRDGKDLLAQWRESNP 239
            |  .:||.||:.   ..:::||||||      :|....|          |.|||:|:.:|...:.
Human   200 EGCQDIATQLIS---NMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQ 261

  Fly   240 NGCFSRSLKELRNCT-DATGT-LLGIFSDSHMSYHLAASKEL-PRLCDMAAAAIEKLERKSQEDG 301
            ...:..:..||...: |.:.| |:|:|......|.:.....| |.|.:|..||:..|.|..:
Human   262 GAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPR--- 323

  Fly   302 NGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTLSMSGYA 366
             |:::|:|||||||||||.....||.|.|.||.|:|...|:|...|||.:|||||||..|..||.
Human   324 -GFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYT 387

  Fly   367 KRGTPILGMDAQQRDVNGVPYSTLNYAIGKWQSLDKDGRRE-SPSKTLSPTSYTPSYIHGRKGVH 430
            .||:.|.|: |..:..:...|:::.|..|.....:...|.: :.|::.||.....:.:......|
Human   388 LRGSSIFGL-APSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETH 451

  Fly   431 SGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCN 474
            .||||.|||.|||:||..||.||:.:.|:|.:|||| ...|.|:
Human   452 GGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACL-EPYTACD 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:474031	173/442 (39%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:395188	173/442 (39%)