DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp11 and ALPI

DIOPT Version :9

Sequence 1:	NP_573047.1	Gene:	Alp11 / 32496	FlyBaseID:	FBgn0030661	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001622.2	Gene:	ALPI / 248	HGNCID:	437	Length:	528	Species:	Homo sapiens

Alignment Length:	499	Identity:	191/499 - (38%)
Similarity:	265/499 - (53%)	Gaps:	57/499 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILALSVPMVEQVQPADELLSSHWLRQAQSQLRERLARTKDSIADVRQAKNVVMLLGDGLSITTLT 84
            :|.|.:.:...|.||:|...:.|.|||...|  ..|:....|..|  |||:::.|||||.:.|:|
Human     9 LLGLRLQLSLGVIPAEEENPAFWNRQAAEAL--DAAKKLQPIQKV--AKNLILFLGDGLGVPTVT 69

  Fly    85 AARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVKTHSGTVGQSGS 149
            |.||||||:.|..|.:..||:::||:..|||||.:|.|.||||.|||||..|||.:..|:|.|.:
Human    70 ATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAA 134

  Fly   150 ----------GERVDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRRG------------E 192
                      |..|.||:..|::|||:.|||||||:..|||||.|||...|.            :
Human   135 ARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQ 199

  Fly   193 E--LEIARQLVEEEPGRNLNVILGGG------LGKFADE----------RRDGKDLLAQWRESNP 239
            |  .:||.||:.   ..:::||||||      :|....|          |.|||:|:.:|...:.
Human   200 EGCQDIATQLIS---NMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQ 261

  Fly   240 NGCFSRSLKELRNCT-DATGT-LLGIFSDSHMSYHLAASKEL-PRLCDMAAAAIEKLERKSQEDG 301
            ...:..:..||...: |.:.| |:|:|......|.:.....| |.|.:|..||:..|.|..:
Human   262 GAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPR--- 323

  Fly   302 NGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTLSMSGYA 366
             |:::|:|||||||||||.....||.|.|.||.|:|...|:|...|||.:|||||||..|..||.
Human   324 -GFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYT 387

  Fly   367 KRGTPILGMDAQQRDVNGVPYSTLNYAIGKWQSLDKDGRRE-SPSKTLSPTSYTPSYIHGRKGVH 430
            .||:.|.|: |..:..:...|:::.|..|.....:...|.: :.|::.||.....:.:......|
Human   388 LRGSSIFGL-APSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETH 451

  Fly   431 SGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCN 474
            .||||.|||.|||:||..||.||:.:.|:|.:|||| ...|.|:
Human   452 GGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACL-EPYTACD 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	173/442 (39%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	173/442 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760