Protein Alignment Alp11 and ALPI

DIOPT Version :8

• Sequence 1: NP_573047.1
• Gene: Alp11 / 32496
• FlyBaseID: FBgn0030661
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001622.2
• Gene: ALPI / 248
• HGNCID: 437
• Length: 528
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 191/500 (38%)
• Similarity: 265/500 (53%)
• Gaps: 57/500 (11%)

  Fly    20 ILALSVPMVEQVQPADELLSSHWLRQAQSQLRERLARTKDSIADVRQAKNVVMLLGDGLSITTLT 84
            :|.|.:.:...|.||:|...:.|.|||...|  ..|:....|..|  |||:::.|||||.:.|:|
Human     9 LLGLRLQLSLGVIPAEEENPAFWNRQAAEAL--DAAKKLQPIQKV--AKNLILFLGDGLGVPTVT 69

  Fly    85 AARILKGQRRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATAYFGGVKTHSGTVGQSGS 149
            |.||||||:.|..|.:..||:::||:..|||||.:|.|.||||.|||||..|||.:..|:|.|.:
Human    70 ATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAA 134

  Fly   150 ----------GERVDSVLQWAQRAGKATGVVTTTRLTDASPAGAYAHVSRRG------------E 192
                      |..|.||:..|::|||:.|||||||:..|||||.|||...|.            :
Human   135 ARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQ 199

  Fly   193 E--LEIARQLVEEEPGRNLNVILGGG------LGKFADE----------RRDGKDLLAQWRESNP 239
            |  .:||.||:.   ..:::||||||      :|....|          |.|||:|:.:|...:.
Human   200 EGCQDIATQLIS---NMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQ 261

  Fly   240 NGCFSRSLKELRNCT-DATGT-LLGIFSDSHMSYHLAASKEL-PRLCDMAAAAIEKLERKSQEDG 301
            ...:..:..||...: |.:.| |:|:|......|.:.....| |.|.:|..||:..|.|..:
Human   262 GAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPR--- 323

  Fly   302 NGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDPRDTLVVVTADHSHTLSMSGYA 366
             |:::|:|||||||||||.....||.|.|.||.|:|...|:|...|||.:|||||||..|..||.
Human   324 -GFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYT 387

  Fly   367 KRGTPILGMDAQQRDVNGVPYSTLNYAIGKWQSLDKDGRRE-SPSKTLSPTSYTPSYIHGRKGVH 430
            .||:.|.|: |..:..:...|:::.|..|.....:...|.: :.|::.||.....:.:......|
Human   388 LRGSSIFGL-APSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETH 451

  Fly   431 SGEDVVVFAMGPQSHLFGGVMEQNLLPHIMGYAACLGNGLTLCN 474
            .||||.|||.|||:||..||.||:.:.|:|.:|||| ...|.|:
Human   452 GGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACL-EPYTACD 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp11	NP_573047.1	ALP_like	68..467	CDD:304875	174/443 (39%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	174/443 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C21922218
eggNOG	1	0.900				E1_COG1785
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D216917at33208
OrthoFinder	1	1.000				FOG0000248
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_126976
Panther	1	1.100			O	PTHR11596
Phylome	1	0.910		0.778	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750